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Q8PH20 (HPPA_XANAC) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
K(+)-insensitive pyrophosphate-energized proton pump
EC=3.6.1.1
Alternative name(s):
Membrane-bound proton-translocating pyrophosphatase
Pyrophosphate-energized inorganic pyrophosphatase
Short name=H(+)-PPase
Gene names
Name:hppA
Ordered Locus Names:XAC3440
OrganismXanthomonas axonopodis pv. citri (Citrus canker) [Complete proteome] [HAMAP]
Taxonomic identifier92829 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas

Protein attributes

Sequence length675 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force By similarity. HAMAP MF_01129

Catalytic activity

Diphosphate + H2O = 2 phosphate. HAMAP MF_01129

Cofactor

Magnesium By similarity. HAMAP MF_01129

Subunit structure

Homodimer By similarity. HAMAP MF_01129

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01129.

Sequence similarities

Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily. [View classification]

Ontologies

Keywords
   Biological processHydrogen ion transport
Ion transport
Transport
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandMagnesium
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processproton transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionhydrogen-translocating pyrophosphatase activity

Inferred from electronic annotation. Source: InterPro

inorganic diphosphatase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 675675K(+)-insensitive pyrophosphate-energized proton pump HAMAP MF_01129
PRO_0000217034

Regions

Transmembrane5 – 2521Helical; Potential
Transmembrane65 – 8521Helical; Potential
Transmembrane129 – 14921Helical; Potential
Transmembrane164 – 18421Helical; Potential
Transmembrane231 – 25121Helical; Potential
Transmembrane258 – 27821Helical; Potential
Transmembrane287 – 30721Helical; Potential
Transmembrane321 – 34121Helical; Potential
Transmembrane384 – 40421Helical; Potential
Transmembrane405 – 42521Helical; Potential
Transmembrane458 – 47821Helical; Potential
Transmembrane500 – 52021Helical; Potential
Transmembrane568 – 58821Helical; Potential
Transmembrane590 – 61021Helical; Potential
Transmembrane655 – 67521Helical; Potential

Sites

Site4571Determinant of potassium independence By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8PH20 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 05C28DAEDFA8106B

FASTA67569,285
        10         20         30         40         50         60 
MLEHYGLWLA LGCAVLAIVY GIVSARWVVA QPSGNARMQE IAAAIQEGAR AYLNRQYLTI 

        70         80         90        100        110        120 
SVAGAVLFVL VGLFLSWYTA IGFALGAVLS GLAGYIGMNV SVRANVRTAE AARHGIGKAM 

       130        140        150        160        170        180 
DVAFRGGAIT GMLVVGLGLL GVAGYFAVLQ GMGLPLEQNL HALVGLAFGS SLISIFARLG 

       190        200        210        220        230        240 
GGIFTKGADV GADLVGKVEA GIPEDDPRNP AVIADNVGDN VGDCAGMAAD LFETYAVTVI 

       250        260        270        280        290        300 
ATMLLGSLTL ADTGSHAVLY PLVLGGVSII ASIVGAAFVK VKDGGSIMGA LYKGVIVSGV 

       310        320        330        340        350        360 
LAALAYWPIT QSLMRDNIHG ATALYACALI GLVLTGLIVW ITEYYTGTQY TPVQHVASAS 

       370        380        390        400        410        420 
TTGHGTNIIA GLGISMKSTA LPVIAVCAAI WGAFHFGGLY GIAIAATAML SMAGMIVALD 

       430        440        450        460        470        480 
AYGPITDNAG GIAEMAELPP EVRNITDPLD AVGNTTKAVT KGYAIGSAAL AALVLFADYT 

       490        500        510        520        530        540 
HNLQAANPDQ VYAFDLSDHT VIIGLLIGGL IPYLFGAMAM EAVGRAAGAV VEEVRRQFRE 

       550        560        570        580        590        600 
LPGIMAGTAK PQYDRAVDML TRSAIGEMIV PSLLPVVVPI IVGLLLGPRA LGGLLIGTIV 

       610        620        630        640        650        660 
TGLFLAISMT TGGGAWDNAK KYIEDGHFGG KGSEAHKAAI TGDTVGDPYK DTAGPAINPL 

       670 
IKIINIVALL LVPLL

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE008923 Genomic DNA. Translation: AAM38283.1.
RefSeqNP_643747.1. NC_003919.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1157511.
GenomeReviewsGene locus XAC3440 in contig AE008923_GR.
KEGGxac:XAC3440.
NMPDRfig|190486.1.peg.3391.
PATRIC24059015. VBIXanAxo33670_3559.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG593668.
OMAIAEMSGL.
ProtClustDBPRK00733.

Enzyme and pathway databases

BioCycXAXO190486:XAC3440-MONOMER.

Family and domain databases

HAMAPMF_01129. PPase-energized_pump.
[Tree]
InterProIPR004131. PPase-energised_H-pump.
[Graphical view]
KOK01507.
PfamPF03030. H_PPase. 1 hit.
[Graphical view]
PIRSFPIRSF001265. H+-PPase. 1 hit.
TIGRFAMsTIGR01104. V_PPase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHPPA_XANAC
AccessionPrimary (citable) accession number: Q8PH20
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: October 1, 2002
Last modified: January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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