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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Xanthomonas axonopodis pv. citri (strain 306)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:XAC3521
OrganismiXanthomonas axonopodis pv. citri (strain 306)
Taxonomic identifieri190486 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000000576 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002058511 – 392Nicotinate phosphoribosyltransferaseAdd BLAST392

Interactioni

Protein-protein interaction databases

STRINGi190486.XAC3521

Structurei

3D structure databases

ProteinModelPortaliQ8PGU5
SMRiQ8PGU5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RH7 Bacteria
COG1488 LUCA
HOGENOMiHOG000284929
KOiK00763
OMAiKLTMQCA
OrthoDBiPOG091H0197

Family and domain databases

CDDicd01401 PncB_like, 1 hit
HAMAPiMF_00570 NAPRTase, 1 hit
InterProiView protein in InterPro
IPR006406 Nic_PRibTrfase
IPR007229 Nic_PRibTrfase-Fam
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 1 hit
TIGRFAMsiTIGR01514 NAPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

Q8PGU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIHSLLDTD LYKFTMMQAV LHQHPAAQVD YRFKCRTPGV DLAQFIDEIS
60 70 80 90 100
REIDALCRLR LREDEVDYLR SLRFIKPDFA DFLALFHLDR KYLSLTASAT
110 120 130 140 150
HPGEIELTIR GPWLHTILFE VPLLAIINEV WFRNTSEPDF EEGRSRLREK
160 170 180 190 200
VASLRSMPAG CKIADYGTRR RYSRQWHGEL LPLLRDGLGE QFVGTSNVYF
210 220 230 240 250
AKQYGLTPLG TMAHEYLQAF QALGPRLRDS QVAALESWAR EYRGDLGIAL
260 270 280 290 300
SDVVGLDAFL RDFDLYFCKL FDGMRHDSGD PFEWGERVIA HLEAHRVDPR
310 320 330 340 350
TKVLVFSDGL NIDKVMRLYQ HFHTRCRLAF GVGTSLTNDL GPTPLQIVIK
360 370 380 390
MVRCNGQPVA KLSDSPGKSM CEDIGYLRYL RDVFGLPPMA ET
Length:392
Mass (Da):44,920
Last modified:October 10, 2002 - v1
Checksum:i319B228E08823664
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008923 Genomic DNA Translation: AAM38364.1
RefSeqiWP_003490746.1, NC_003919.1

Genome annotation databases

EnsemblBacteriaiAAM38364; AAM38364; XAC3521
KEGGixac:XAC3521

Similar proteinsi

Entry informationi

Entry nameiPNCB_XANAC
AccessioniPrimary (citable) accession number: Q8PGU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: April 25, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health