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Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Xanthomonas axonopodis pv. citri (strain 306)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation
  • pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPolyamine biosynthesis, Spermidine biosynthesis
LigandMagnesium, Metal-binding, Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
ADCUniRule annotation
Gene namesi
Name:speAUniRule annotation
Ordered Locus Names:XAC3923
OrganismiXanthomonas axonopodis pv. citri (strain 306)
Taxonomic identifieri190486 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000000576 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001499871 – 628Biosynthetic arginine decarboxylaseAdd BLAST628

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei99N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi190486.XAC3923

Structurei

3D structure databases

ProteinModelPortaliQ8PFQ5
SMRiQ8PFQ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni279 – 289Substrate-bindingUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DP5 Bacteria
COG1166 LUCA
HOGENOMiHOG000029191
KOiK01585
OMAiLFPIMPI
OrthoDBiPOG091H04NG

Family and domain databases

CDDicd06830 PLPDE_III_ADC, 1 hit
Gene3Di2.40.37.10, 3 hits
3.20.20.10, 1 hit
HAMAPiMF_01417 SpeA, 1 hit
InterProiView protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR002985 Arg_decrbxlase
IPR022657 De-COase2_CS
IPR022644 De-COase2_N
IPR000183 Orn/DAP/Arg_de-COase
IPR029066 PLP-binding_barrel
PANTHERiPTHR43295 PTHR43295, 1 hit
PfamiView protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PIRSFiPIRSF001336 Arg_decrbxlase, 1 hit
PRINTSiPR01180 ARGDCRBXLASE
PR01179 ODADCRBXLASE
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR01273 speA, 1 hit
PROSITEiView protein in PROSITE
PS00879 ODR_DC_2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8PFQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDWSLDQAR KTYSIPHWAD GYFDVNAAGH VVVTPTADGP AVSLPEVVDA
60 70 80 90 100
ARAAGAKLPL LVRFPDILGQ RLGKLQAAFA QAQSEWDYAG GYTAVYPIKV
110 120 130 140 150
NQHRGVAGTL ASHHGEGFGL EAGSKPELMA VLALSRPGGL IVCNGYKDRE
160 170 180 190 200
YIRLALIGRK LGLQTFIVIE KPSELTLVLE EARALDVKPG LGVRMRLASL
210 220 230 240 250
GAGKWQNSGG DKAKFGLSPR QVLDLWKTLR DTEYADSLNL LHFHMGSQIS
260 270 280 290 300
NVRDIANGMR EATRYFVELS RLGAKISHVD VGGGLGIDYE GTRSRSYCSI
310 320 330 340 350
NYGLHSYASN IVQPLASACE EHGLTPPRIV TECGRAMTAH HAVLIANVSE
360 370 380 390 400
VEQAPEGRVP DAHDDEPAAI RHLREIHDEL DVRPAVELFQ EAQHFHAEGL
410 420 430 440 450
SAYALGQIDL THRARIDDLF YAIAHGVRAR LSFDEKSHRP VLDELNERLV
460 470 480 490 500
DKYFVNFSVF ESIPDVWAID QVFPIVPIER LNEAPQRRGI IADMTCDSDG
510 520 530 540 550
MVKTYVENES LDSSLPLHRL NAGESYRIGF FLVGAYQEIL GDIHNLFGDT
560 570 580 590 600
DAVEVVVDRD GYRIAQQRRG DTTDVMLDYV GYQLDTLRAT YAERIAAAHL
610 620
SPERAQELSA ALEAGLTGYT YLSDEPLG
Length:628
Mass (Da):69,091
Last modified:March 29, 2004 - v2
Checksum:iCF03AC36E3066C05
GO

Sequence cautioni

The sequence AAM38760 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008923 Genomic DNA Translation: AAM38760.1 Different initiation.
RefSeqiWP_003491107.1, NC_003919.1

Genome annotation databases

EnsemblBacteriaiAAM38760; AAM38760; XAC3923
KEGGixac:XAC3923

Entry informationi

Entry nameiSPEA_XANAC
AccessioniPrimary (citable) accession number: Q8PFQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 29, 2004
Last modified: March 28, 2018
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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