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Q8PFH5 (SYW_XANAC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:XAC4006
OrganismXanthomonas axonopodis pv. citri (strain 306) [Complete proteome] [HAMAP]
Taxonomic identifier190486 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 432432Tryptophan--tRNA ligase HAMAP-Rule MF_00140
PRO_0000136712

Regions

Motif14 – 229"HIGH" region HAMAP-Rule MF_00140
Motif205 – 2095"KMSKS" region HAMAP-Rule MF_00140

Sites

Binding site2081ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8PFH5 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 03AB83E7B8150975

FASTA43247,044
        10         20         30         40         50         60 
MTSMTTRVLT GITTSGTPHL GNYVGAIRPA IQASAGADAE SFYFLADLHS LIKAQDPART 

        70         80         90        100        110        120 
QRSTLEIAAT WLACGLDPDK VWFYRQSDVP ETTELMWLLT CVAGKGILNR AHAYKAAVDR 

       130        140        150        160        170        180 
NRADGEDEDA GVTAGLFMYP VLMAADILIF NAHQVPVGRD QIQHIEMARD FAQRFNHVYG 

       190        200        210        220        230        240 
REFFTLPEAV IDEQVSTLPG LDGRKMSKSY GNTIPLFAPR EELRKLVFSI LTDSRAPGQA 

       250        260        270        280        290        300 
KDTQGSALFQ LYQAFATPQE SAAFAQAFAD GIGWGDAKQQ VFERIDQEIA PLRTRYEGLI 

       310        320        330        340        350        360 
AEPARIEAIL RAGGARLRAR YATPLLAELR DAVGLRDLSS QAATAAVHAS EKIALPVFKQ 

       370        380        390        400        410        420 
YRESDGQFYF KLNDGAGALL LQSDGFASPR DAGQVIARLK QAAQASDLQL PGVHAQVDAD 

       430 
VVLAAMDALR EA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008923 Genomic DNA. Translation: AAM38842.1.
RefSeqNP_644306.1. NC_003919.1.

3D structure databases

ProteinModelPortalQ8PFH5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING190486.XAC4006.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM38842; AAM38842; XAC4006.
GeneID1158077.
KEGGxac:XAC4006.
PATRIC24060164. VBIXanAxo33670_4125.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0180.
HOGENOMHOG000059939.
KOK01867.
OMAKGCETAR.
OrthoDBEOG686NJQ.

Enzyme and pathway databases

BioCycXAXO190486:GH55-4006-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_B. Trp_tRNA_synth_B.
InterProIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYW_XANAC
AccessionPrimary (citable) accession number: Q8PFH5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries