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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Xanthomonas axonopodis pv. citri (strain 306)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei146L-tryptophanUniRule annotation1
Binding sitei198ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 15ATPUniRule annotation3
Nucleotide bindingi21 – 22ATPUniRule annotation2
Nucleotide bindingi158 – 160ATPUniRule annotation3
Nucleotide bindingi205 – 209ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:XAC4006
OrganismiXanthomonas axonopodis pv. citri (strain 306)
Taxonomic identifieri190486 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000000576 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367121 – 432Tryptophan--tRNA ligaseAdd BLAST432

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi190486.XAC4006

Structurei

3D structure databases

ProteinModelPortaliQ8PFH5
SMRiQ8PFH5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi14 – 22"HIGH" regionUniRule annotation9
Motifi205 – 209"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
HOGENOMiHOG000059939
KOiK01867
OMAiQRMTQFK
OrthoDBiPOG091H00I9

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
IPR036913 YegP-like_sf
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
SUPFAMiSSF160113 SSF160113, 1 hit
TIGRFAMsiTIGR00233 trpS, 1 hit

Sequencei

Sequence statusi: Complete.

Q8PFH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSMTTRVLT GITTSGTPHL GNYVGAIRPA IQASAGADAE SFYFLADLHS
60 70 80 90 100
LIKAQDPART QRSTLEIAAT WLACGLDPDK VWFYRQSDVP ETTELMWLLT
110 120 130 140 150
CVAGKGILNR AHAYKAAVDR NRADGEDEDA GVTAGLFMYP VLMAADILIF
160 170 180 190 200
NAHQVPVGRD QIQHIEMARD FAQRFNHVYG REFFTLPEAV IDEQVSTLPG
210 220 230 240 250
LDGRKMSKSY GNTIPLFAPR EELRKLVFSI LTDSRAPGQA KDTQGSALFQ
260 270 280 290 300
LYQAFATPQE SAAFAQAFAD GIGWGDAKQQ VFERIDQEIA PLRTRYEGLI
310 320 330 340 350
AEPARIEAIL RAGGARLRAR YATPLLAELR DAVGLRDLSS QAATAAVHAS
360 370 380 390 400
EKIALPVFKQ YRESDGQFYF KLNDGAGALL LQSDGFASPR DAGQVIARLK
410 420 430
QAAQASDLQL PGVHAQVDAD VVLAAMDALR EA
Length:432
Mass (Da):47,044
Last modified:October 1, 2002 - v1
Checksum:i03AB83E7B8150975
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008923 Genomic DNA Translation: AAM38842.1

Genome annotation databases

EnsemblBacteriaiAAM38842; AAM38842; XAC4006
KEGGixac:XAC4006

Similar proteinsi

Entry informationi

Entry nameiSYW_XANAC
AccessioniPrimary (citable) accession number: Q8PFH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health