Reviewed, UniProtKB/Swiss-Prot Q8PEW5 (XYLA2_XANAC)

Names and origin

Protein names

Recommended name:
    Xylose isomerase 2
    EC=5.3.1.5

Gene names

Name:	xylA2
Ordered Locus Names:	XAC4225

Organism

Xanthomonas axonopodis pv. citri (Citrus canker) [Complete proteome] [HAMAP]

Taxonomic identifier

92829 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas

Protein attributes

Sequence length	445 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-xylose = D-xylulose. HAMAP MF_00455
Cofactor	Binds 2 magnesium ions per subunit By similarity.
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the xylose isomerase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Pentose shunt Xylose metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	D-xylose metabolic process Inferred from electronic annotation. Source: HAMAP pentose-phosphate shunt Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: HAMAP xylose isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 445	445	Xylose isomerase 2 HAMAP MF_00455		PRO_0000195820
Sites
	Active site	109	1	By similarity
	Active site	112	1	By similarity
	Metal binding	240	1	Magnesium 1 By similarity
	Metal binding	276	1	Magnesium 1 By similarity
	Metal binding	276	1	Magnesium 2 By similarity
	Metal binding	279	1	Magnesium 2 By similarity
	Metal binding	304	1	Magnesium 1 By similarity
	Metal binding	315	1	Magnesium 2 By similarity
	Metal binding	317	1	Magnesium 2 By similarity
	Metal binding	347	1	Magnesium 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8PEW5-1 [UniParc]. Last modified July 19, 2004. Version 2. Checksum: B1FDDDECCA70D0E3	FASTA	445	48,766
	10 20 30 40 50 60 MSNTVYIGAK EYFPGIGKIG FEGRDSDNPL AFKVYDANKT IGDKTMAEHL RFAVAYWHSF 70 80 90 100 110 120 CGNGADPFGP GTRAYPWDVG DTALNRAEAK ADAAFEFFTK LGVPYYCFHD IDLSPDADDI 130 140 150 160 170 180 TEYESNLKHM VGVAKQRQAD TGIKLLWGTA NLFSHPRYMN GASTNPDFNV VARAAVQVKA 190 200 210 220 230 240 AIDATVALGG ENYVFWGGRE GYACLHNTQM KREQDNMARF LTLARDYGRS IGFKGNFLIE 250 260 270 280 290 300 PKPMEPMKHQ YDFDSATVIG FLRQHGLDQD FKLNIEANHA TLSGHSFEHD LQVASDAGLL 310 320 330 340 350 360 GSIDANRGNP QNGWDTDQFP TDLYDTVGAM LVVLRQGGLA PGGLNFDAKV RRESSDPQDL 370 380 390 400 410 420 FLAHIGGMDA FARGLEVANA LLTASPLEQW RAERYASFDS GAGADFAAGK TTLADLAKHA 430 440 AGNAPQQISG RQEAYENLIN QYLTR

References

[1]

"Comparison of the genomes of two Xanthomonas pathogens with differing host specificities." da Silva A.C.R., Ferro J.A., Reinach F.C., Farah C.S., Furlan L.R., Quaggio R.B., Monteiro-Vitorello C.B., Van Sluys M.A., Almeida N.F. Jr., Alves L.M.C., do Amaral A.M., Bertolini M.C., Camargo L.E.A., Camarotte G., Cannavan F., Cardozo J., Chambergo F., Ciapina L.P. , Cicarelli R.M.B., Coutinho L.L., Cursino-Santos J.R., El-Dorry H., Faria J.B., Ferreira A.J.S., Ferreira R.C.C., Ferro M.I.T., Formighieri E.F., Franco M.C., Greggio C.C., Gruber A., Katsuyama A.M., Kishi L.T., Leite R.P., Lemos E.G.M., Lemos M.V.F., Locali E.C., Machado M.A., Madeira A.M.B.N., Martinez-Rossi N.M., Martins E.C., Meidanis J., Menck C.F.M., Miyaki C.Y., Moon D.H., Moreira L.M., Novo M.T.M., Okura V.K., Oliveira M.C., Oliveira V.R., Pereira H.A., Rossi A., Sena J.A.D., Silva C., de Souza R.F., Spinola L.A.F., Takita M.A., Tamura R.E., Teixeira E.C., Tezza R.I.D., Trindade dos Santos M., Truffi D., Tsai S.M., White F.F., Setubal J.C., Kitajima J.P. Nature 417:459-463(2002) [PubMed: 12024217] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 306.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE008923 Genomic DNA. Translation: AAM39060.1. Different initiation.
RefSeq	NP_644524.2.
3D structure databases
HSSP	HSSP built from PDB template 1A0C based on UniProtKB P19148.
ModBase	Search...
Genome annotation databases
GeneID	1158296.
GenomeReviews	Gene locus XAC4225 in contig AE008923_GR.
KEGG	xac:XAC4225.
NMPDR	fig|190486.1.peg.4168.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8PEW5.
Enzyme and pathway databases
BioCyc	XAXO190486:XAC4225-MON.
BRENDA	5.3.1.5. 289771.
Family and domain databases
HAMAP	MF_00455. [Tree]
InterPro	IPR013022. Xyl_isomerase-like_TIM-brl. IPR012307. Xyl_isomerase_TIM-brl. IPR013452. Xylose_isom_bac. IPR001998. Xylose_isomerase. IPR018115. Xylose_isomerase_AS. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
Pfam	PF01261. AP_endonuc_2. 1 hit. [Graphical view]
PRINTS	PR00688. XYLOSISMRASE.
TIGRFAMs	TIGR02630. xylose_isom_A. 1 hit.
PROSITE	PS51415. XYLOSE_ISOMERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XYLA2_XANAC

Accession

Primary (citable) accession number: Q8PEW5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 19, 2004
Last modified:	October 13, 2009
This is version 42 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)