ID   UXAC_XANAC              Reviewed;         472 AA.
AC   Q8PET9;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 99.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675}; Synonyms=hrmI;
GN   OrderedLocusNames=XAC4251;
OS   Xanthomonas axonopodis pv. citri (strain 306).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xanthomonas.
OX   NCBI_TaxID=190486;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=306;
RX   PubMed=12024217; DOI=10.1038/417459a;
RA   da Silva A.C.R., Ferro J.A., Reinach F.C., Farah C.S., Furlan L.R.,
RA   Quaggio R.B., Monteiro-Vitorello C.B., Van Sluys M.A., Almeida N.F. Jr.,
RA   Alves L.M.C., do Amaral A.M., Bertolini M.C., Camargo L.E.A., Camarotte G.,
RA   Cannavan F., Cardozo J., Chambergo F., Ciapina L.P., Cicarelli R.M.B.,
RA   Coutinho L.L., Cursino-Santos J.R., El-Dorry H., Faria J.B.,
RA   Ferreira A.J.S., Ferreira R.C.C., Ferro M.I.T., Formighieri E.F.,
RA   Franco M.C., Greggio C.C., Gruber A., Katsuyama A.M., Kishi L.T.,
RA   Leite R.P., Lemos E.G.M., Lemos M.V.F., Locali E.C., Machado M.A.,
RA   Madeira A.M.B.N., Martinez-Rossi N.M., Martins E.C., Meidanis J.,
RA   Menck C.F.M., Miyaki C.Y., Moon D.H., Moreira L.M., Novo M.T.M.,
RA   Okura V.K., Oliveira M.C., Oliveira V.R., Pereira H.A., Rossi A.,
RA   Sena J.A.D., Silva C., de Souza R.F., Spinola L.A.F., Takita M.A.,
RA   Tamura R.E., Teixeira E.C., Tezza R.I.D., Trindade dos Santos M.,
RA   Truffi D., Tsai S.M., White F.F., Setubal J.C., Kitajima J.P.;
RT   "Comparison of the genomes of two Xanthomonas pathogens with differing host
RT   specificities.";
RL   Nature 417:459-463(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; AE008923; AAM39086.1; -; Genomic_DNA.
DR   RefSeq; WP_005916173.1; NC_003919.1.
DR   AlphaFoldDB; Q8PET9; -.
DR   SMR; Q8PET9; -.
DR   GeneID; 66913231; -.
DR   KEGG; xac:XAC4251; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_0_0_6; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000000576; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   Gene3D; 1.10.2020.10; uronate isomerase, domain 2, chain A; 1.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   PANTHER; PTHR30068; URONATE ISOMERASE; 1.
DR   PANTHER; PTHR30068:SF4; URONATE ISOMERASE; 1.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..472
FT                   /note="Uronate isomerase"
FT                   /id="PRO_0000172794"
SQ   SEQUENCE   472 AA;  52896 MW;  8F59D75349D217CC CRC64;
     MRSSVLSLHP DRLLPADPGT RAIARRLYAQ VATLPIISPH GHTDPAWFAT NAPFANATEL
     LLVPDHYVFR MLYSQGIDLD ALGIPRADGT RATVDPRAAW RVFAEHYTLL RGTPSALWLN
     HVFHDVFDLR IRLDAGTADH YYDHITAALQ TPAFLPRALF ERFNIEVIAT TESPLDRLQH
     HAAIAASGWQ GRVVTAYRPD PVVDPEHEQF AGALQQFGAL TGEDVLTWDG YLRAHRQRRA
     FFAAHGATST DHGHPSAATA DLSPAEAQRL FDTVVRGAAT PEQAELFRAQ VLTEMAAMSL
     DDGLVMQLHP GCFRNHNRQL FEQYGRDKGA DIPMRTDYVH ALKPLLDRHG NDPRLRLIVF
     TLDETSYSRE LAPLAGHYPS LLLGPAWWFH DAPEGMWRFR EQTLASAGFY NTVGFNDDTR
     AFLSIPARHD VARRVDSAFL AKLVAEHRLE EDEATEVAID LAYRLPKQAY KL
//