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Q8PEP3 (GCH1_XANAC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:XAC4302
OrganismXanthomonas axonopodis pv. citri (strain 306) [Complete proteome] [HAMAP]
Taxonomic identifier190486 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

Protein attributes

Sequence length200 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence caution

The sequence AAM39132.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 200200GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_0000119466

Sites

Metal binding871Zinc By similarity
Metal binding901Zinc By similarity
Metal binding1581Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8PEP3 [UniParc].

Last modified November 15, 2002. Version 2.
Checksum: AF91D4AF9D14D802

FASTA20022,626
        10         20         30         40         50         60 
MSQSNQPDSP VTQTQAEEAV RTLLRWAGED PTREGLLDTP RRVAEAYGDW FSGYRDEPRE 

        70         80         90        100        110        120 
YLERTFEEVA GYDELIVLRD ISYESHCEHH MAPIIGKVHV GYLPRGKVVG ISKLARVVES 

       130        140        150        160        170        180 
YARRFQVQEK MTAQIAQCIQ DVLQPLGVGV VVEGAHECMT TRGIHKRGVS MVTSKMLGSF 

       190        200 
REDARTRAEF LQFIEVGGKR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008923 Genomic DNA. Translation: AAM39132.1. Different initiation.
RefSeqNP_644596.1. NC_003919.1.

3D structure databases

ProteinModelPortalQ8PEP3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING190486.XAC4302.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM39132; AAM39132; XAC4302.
GeneID1158373.
KEGGxac:XAC4302.
PATRIC24060804. VBIXanAxo33670_4440.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0302.
HOGENOMHOG000221222.
KOK01495.
OMAKRTYDEE.
OrthoDBEOG6XHC8G.

Enzyme and pathway databases

BioCycXAXO190486:GH55-4302-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_XANAC
AccessionPrimary (citable) accession number: Q8PEP3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 15, 2002
Last modified: May 14, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways