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Q8PE75

- LLDD_XANCP

UniProt

Q8PE75 - LLDD_XANCP

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Protein

L-lactate dehydrogenase

Gene
lldD, XCC0106
Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain By similarity.

Catalytic activityi

(S)-lactate + an oxidized electron acceptor = pyruvate + a reduced electron acceptor.

Cofactori

FMN By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei24 – 241Substrate Reviewed prediction
Binding sitei106 – 1061FMN By similarity
Binding sitei127 – 1271FMN By similarity
Binding sitei129 – 1291Substrate By similarity
Binding sitei155 – 1551FMN By similarity
Binding sitei164 – 1641Substrate By similarity
Binding sitei251 – 2511FMN By similarity
Active sitei275 – 2751Proton acceptor By similarity
Binding sitei278 – 2781Substrate Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi306 – 33025FMN By similarityAdd
BLAST

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. L-lactate dehydrogenase (cytochrome) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lactate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

BioCyciXCAM190485:GIXZ-106-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenase (EC:1.1.-.-)
Gene namesi
Name:lldD
Ordered Locus Names:XCC0106
OrganismiXanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
Taxonomic identifieri190485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000001010: Chromosome

Subcellular locationi

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 386386L-lactate dehydrogenasePRO_0000206355Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi190485.XCC0106.

Structurei

3D structure databases

ProteinModelPortaliQ8PE75.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 380380FMN hydroxy acid dehydrogenaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1304.
HOGENOMiHOG000217464.
KOiK00101.
OMAiPWFQLYM.
OrthoDBiEOG6HMXBG.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01559. L_lact_dehydr.
InterProiIPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
IPR020920. L-lactate_DHase_bac.
[Graphical view]
PfamiPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEiPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8PE75-1 [UniParc]FASTAAdd to Basket

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MIISAASDYR AAAEARLPPF LFHYIDGGAY AEHTLRRNVS DLADIALRQR    50
VLRNMSDLSL STELFGETLA MPVALAPVGL TGMYARRGEV QAARAAAARG 100
IPFTLSTVSV CPIEEVAPAI DRPMWFQLYV LKDRGFMRNA LERAKTAGVT 150
TLVFTVDMPT PGARYRDAHS GMSGPNASLR RMLQAMTHPR WAWDVGLLGK 200
PHDLGNISTY RGSPTGLQDY IGWLAANFDP SISWKDLEWI REFWTGPMVI 250
KGILDPEDAR DAVRFGADGI VVSNHGGRQL DGVLSSARAL PAIADAVKGE 300
LKILADSGIR SGLDVVRMLA LGADAVLLGR AFVYALAAGG QAGVENLLTL 350
IEREMRVAMI LTGTHSVAEI SGDALSRVTR EAAVVP 386
Length:386
Mass (Da):41,622
Last modified:October 1, 2002 - v1
Checksum:i5B3E3BD0B59E46C8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008922 Genomic DNA. Translation: AAM39425.1.
RefSeqiNP_635501.1. NC_003902.1.
WP_011035364.1. NC_003902.1.

Genome annotation databases

EnsemblBacteriaiAAM39425; AAM39425; XCC0106.
GeneIDi1002315.
KEGGixcc:XCC0106.
PATRICi24070761. VBIXanCam115730_0118.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008922 Genomic DNA. Translation: AAM39425.1 .
RefSeqi NP_635501.1. NC_003902.1.
WP_011035364.1. NC_003902.1.

3D structure databases

ProteinModelPortali Q8PE75.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 190485.XCC0106.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM39425 ; AAM39425 ; XCC0106 .
GeneIDi 1002315.
KEGGi xcc:XCC0106.
PATRICi 24070761. VBIXanCam115730_0118.

Phylogenomic databases

eggNOGi COG1304.
HOGENOMi HOG000217464.
KOi K00101.
OMAi PWFQLYM.
OrthoDBi EOG6HMXBG.

Enzyme and pathway databases

BioCyci XCAM190485:GIXZ-106-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01559. L_lact_dehydr.
InterProi IPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
IPR020920. L-lactate_DHase_bac.
[Graphical view ]
Pfami PF01070. FMN_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEi PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiLLDD_XANCP
AccessioniPrimary (citable) accession number: Q8PE75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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