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Q8PDW3 (DDLA_XANCP) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase A

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase A
D-alanylalanine synthetase A
Gene names
Name:ddlA
Synonyms:ddlB
Ordered Locus Names:XCC0222
OrganismXanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568) [Reference proteome] [HAMAP]
Taxonomic identifier190485 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

Protein attributes

Sequence length373 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 373373D-alanine--D-alanine ligase A HAMAP-Rule MF_00047
PRO_0000177908

Regions

Domain150 – 353204ATP-grasp
Nucleotide binding180 – 23556ATP By similarity

Sites

Metal binding3071Magnesium or manganese 1 By similarity
Metal binding3201Magnesium or manganese 1 By similarity
Metal binding3201Magnesium or manganese 2 By similarity
Metal binding3221Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8PDW3 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 01E285702AF9D15F

FASTA37340,110
        10         20         30         40         50         60 
MTGAGMRRIR VGLIFGGKSA EHEVSLQSAR NILQALDPQR FEPVLIGIDK QGQWHLSAQE 

        70         80         90        100        110        120 
SFLLDADDPS RIALRHSGRG LAVLPGAASA QLRAVDAEQA LAQIDVVFPI VHGTLGEDGS 

       130        140        150        160        170        180 
LQGLLRMANL PFVGSGVLGS AVAMDKDMAK RVLRDAGLEV APFACFTRHT AAQADVQTLI 

       190        200        210        220        230        240 
AQFGLPLFVK PANQGSSVGV SQVRSAEEFS AALELALRYD HKVLVEAAIA GREIECAVLG 

       250        260        270        280        290        300 
NATPQASVCG EVVVHDAFYS YQTKYIRDDG AATVIPADID AHTQHRIQQC ALQAYQALDC 

       310        320        330        340        350        360 
AGMARVDVFL CADGRIVINE VNTLPGFTRI SMYPKLWEAS GLDYRSLVTR LIELALERHA 

       370 
DDGRLYSSVV THA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008922 Genomic DNA. Translation: AAM39541.1.
RefSeqNP_635617.2. NC_003902.1.

3D structure databases

ProteinModelPortalQ8PDW3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING190485.XCC0222.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM39541; AAM39541; XCC0222.
GeneID999929.
KEGGxcc:XCC0222.
PATRIC24071023. VBIXanCam115730_0249.

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAMDKIAMK.
OrthoDBEOG64BQ73.
ProtClustDBPRK01966.

Enzyme and pathway databases

BioCycXCAM190485:GIXZ-222-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDLA_XANCP
AccessionPrimary (citable) accession number: Q8PDW3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2002
Last modified: February 19, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways