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Protein

Glycerol kinase

Gene

glpK

Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.UniRule annotation

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotation

Enzyme regulationi

Inhibited by fructose 1,6-bisphosphate (FBP).UniRule annotation

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Glycerol kinase (glpK)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol, the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei13SubstrateUniRule annotation1
Binding sitei17ATPUniRule annotation1
Binding sitei135SubstrateUniRule annotation1
Binding sitei267ATPUniRule annotation1
Binding sitei310ATP; via carbonyl oxygenUniRule annotation1
Binding sitei314ATP; via amide nitrogenUniRule annotation1
Binding sitei329ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 15ATPUniRule annotation3
Nucleotide bindingi411 – 415ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycerol metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciXCAM190485:G1FZM-358-MONOMER
UniPathwayiUPA00618; UER00672

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinaseUniRule annotation (EC:2.7.1.30UniRule annotation)
Alternative name(s):
ATP:glycerol 3-phosphotransferaseUniRule annotation
GlycerokinaseUniRule annotation
Short name:
GKUniRule annotation
Gene namesi
Name:glpKUniRule annotation
Ordered Locus Names:XCC0358
OrganismiXanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Taxonomic identifieri190485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000001010 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000595231 – 499Glycerol kinaseAdd BLAST499

Interactioni

Protein-protein interaction databases

STRINGi190485.XCC0358

Structurei

3D structure databases

ProteinModelPortaliQ8PDI0
SMRiQ8PDI0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni83 – 84Substrate bindingUniRule annotation2
Regioni245 – 246Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the FGGY kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QVN Bacteria
COG0554 LUCA
HOGENOMiHOG000222134
KOiK00864
OMAiWQDTRTQ

Family and domain databases

HAMAPiMF_00186 Glycerol_kin, 1 hit
InterProiView protein in InterPro
IPR000577 Carb_kinase_FGGY
IPR018485 Carb_kinase_FGGY_C
IPR018483 Carb_kinase_FGGY_CS
IPR018484 Carb_kinase_FGGY_N
IPR005999 Glycerol_kin
PfamiView protein in Pfam
PF02782 FGGY_C, 1 hit
PF00370 FGGY_N, 1 hit
PIRSFiPIRSF000538 GlpK, 1 hit
TIGRFAMsiTIGR01311 glycerol_kin, 1 hit
PROSITEiView protein in PROSITE
PS00933 FGGY_KINASES_1, 1 hit
PS00445 FGGY_KINASES_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8PDI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKKYVLAID QGTTSSRAML FDRQGKVAGV AQREFGQIFP QPGWVEHNPR
60 70 80 90 100
EIMTSVYTTI TELLNNAQID AREISGIGIT NQRETAVVWD KATGQPIYNA
110 120 130 140 150
IVWQSRQTKD ICTQLKEAGH EQMVRDKTGL LIDAYFSGTK VKWILDHVDG
160 170 180 190 200
ARERARKGEL AFGTIDSWLI WNLTGGKVHV TDYTNASRTM MYNIHTLEWD
210 220 230 240 250
AELLEMLDVP AQMLPEVRSS SEVYGMTQTQ YFYGEQVPIA GIAGDQQAAL
260 270 280 290 300
FGQACFEPGM AKNTYGTGCF MLMNTGDKAV ASKAGLLTTI AWGIDGKVEY
310 320 330 340 350
ALEGAIFVAG SVVQWLRDGL RMFGKASDSQ AYAERAGDND GVYFVPAFVG
360 370 380 390 400
LGAPYWRSDI RGAVFGLTRG TSKEHFVRAA VESMAYQTRD VLTAMQSDSG
410 420 430 440 450
IELKELRADG GAIANDFMAQ FQSDILNVPV LRPEVAETTA LGAAYLAGLA
460 470 480 490
TGFWSSREEI AKQWAVDRRF EPNMPEERRE QLYAGWQQAV EATMGFRIS
Length:499
Mass (Da):55,248
Last modified:October 1, 2002 - v1
Checksum:i4101C5AC4987B7C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008922 Genomic DNA Translation: AAM39677.1
RefSeqiNP_635753.1, NC_003902.1
WP_011035612.1, NC_003902.1

Genome annotation databases

EnsemblBacteriaiAAM39677; AAM39677; XCC0358
GeneIDi35543920
999339
KEGGixcc:XCC0358
PATRICifig|190485.4.peg.393

Similar proteinsi

Entry informationi

Entry nameiGLPK_XANCP
AccessioniPrimary (citable) accession number: Q8PDI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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