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Q8PDA2

- HGD_XANCP

UniProt

Q8PDA2 - HGD_XANCP

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Protein

Homogentisate 1,2-dioxygenase

Gene

hmgA

Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.UniRule annotation

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

Cofactori

Fe cationUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei308 – 3081Proton acceptorUniRule annotation
Metal bindingi351 – 3511IronUniRule annotation
Metal bindingi357 – 3571IronUniRule annotation
Binding sitei366 – 3661homogentisateUniRule annotation
Metal bindingi387 – 3871IronUniRule annotation
Binding sitei387 – 3871homogentisateUniRule annotation

GO - Molecular functioni

  1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
  2. tyrosine catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciXCAM190485:GIXZ-438-MONOMER.
UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenaseUniRule annotation (EC:1.13.11.5UniRule annotation)
Short name:
HGDOUniRule annotation
Alternative name(s):
Homogentisate oxygenaseUniRule annotation
Homogentisic acid oxidaseUniRule annotation
HomogentisicaseUniRule annotation
Gene namesi
Name:hmgAUniRule annotation
Ordered Locus Names:XCC0438
OrganismiXanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
Taxonomic identifieri190485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000001010: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455Homogentisate 1,2-dioxygenasePRO_0000220258Add
BLAST

Proteomic databases

PRIDEiQ8PDA2.

Interactioni

Subunit structurei

Hexamer; dimer of trimers.UniRule annotation

Protein-protein interaction databases

STRINGi190485.XCC0438.

Structurei

3D structure databases

ProteinModelPortaliQ8PDA2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the homogentisate dioxygenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3508.
HOGENOMiHOG000139824.
KOiK00451.
OMAiFQSPVAC.
OrthoDBiEOG6D5FZK.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_00334. Homogentis_dioxygen.
InterProiIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8PDA2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIQLDPTLLL SWRAGQHPDA PMHNDQRYMT GFGNEFASEA VADTLPVGQN
60 70 80 90 100
SPQRVAHGLY AEQLSGTAFT APRGENRRSW LYRMRPAAVH GTFSLIEQSQ
110 120 130 140 150
FHNDFGHGPV PPDQLRWSPL PLPQTPTDFI DGLYTMAGNG SPEAMNGVAV
160 170 180 190 200
HLYAANASMQ DRFFYNADGE LLLVPQLGRL RVHTELGMLE LEPQQIGVIP
210 220 230 240 250
RGVRFRVELR DGTARGYVCE NFGGLLHLPD LGPIGSNGLA NPRDFETPCA
260 270 280 290 300
AFEQREGRFE LVAKFQGHLW RADIGHSPLD VVAWHGNYAP YRYDLRRFNT
310 320 330 340 350
IGSISFDHPD PSIFTVLTSP SDTHGTANMD FAIFPPRWLV AQHTFRPPWF
360 370 380 390 400
HRNVASEFMG LVHGVYDAKA DGFAPGGASL HNCMSGHGPD AATFDKASQA
410 420 430 440 450
DLSRPDVITE TMAFMFETRA VLRPTAQALH APHRQGDYQQ CWAGLRKAFQ

APPAS
Length:455
Mass (Da):50,406
Last modified:October 10, 2002 - v1
Checksum:i2225A12DAD492A23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008922 Genomic DNA. Translation: AAM39756.1.
RefSeqiNP_635832.1. NC_003902.1.

Genome annotation databases

EnsemblBacteriaiAAM39756; AAM39756; XCC0438.
GeneIDi1000916.
KEGGixcc:XCC0438.
PATRICi24071493. VBIXanCam115730_0483.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008922 Genomic DNA. Translation: AAM39756.1 .
RefSeqi NP_635832.1. NC_003902.1.

3D structure databases

ProteinModelPortali Q8PDA2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 190485.XCC0438.

Proteomic databases

PRIDEi Q8PDA2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM39756 ; AAM39756 ; XCC0438 .
GeneIDi 1000916.
KEGGi xcc:XCC0438.
PATRICi 24071493. VBIXanCam115730_0483.

Phylogenomic databases

eggNOGi COG3508.
HOGENOMi HOG000139824.
KOi K00451.
OMAi FQSPVAC.
OrthoDBi EOG6D5FZK.

Enzyme and pathway databases

UniPathwayi UPA00139 ; UER00339 .
BioCyci XCAM190485:GIXZ-438-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
HAMAPi MF_00334. Homogentis_dioxygen.
InterProi IPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR11056. PTHR11056. 1 hit.
Pfami PF04209. HgmA. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR01015. hmgA. 1 hit.
ProtoNeti Search...

Entry informationi

Entry nameiHGD_XANCP
AccessioniPrimary (citable) accession number: Q8PDA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: November 26, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3