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Protein

Peptide deformylase 1

Gene

def1

Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi99IronUniRule annotation1
Metal bindingi141IronUniRule annotation1
Active sitei142UniRule annotation1
Metal bindingi145IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processProtein biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciXCAM190485:G1FZM-686-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase 1UniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDF 1UniRule annotation
Alternative name(s):
Polypeptide deformylase 1UniRule annotation
Gene namesi
Name:def1UniRule annotation
Ordered Locus Names:XCC0687
OrganismiXanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Taxonomic identifieri190485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000001010 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000828851 – 171Peptide deformylase 1Add BLAST171

Interactioni

Protein-protein interaction databases

STRINGi190485.XCC0687

Structurei

3D structure databases

ProteinModelPortaliQ8PCN7
SMRiQ8PCN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108RBJ Bacteria
COG0242 LUCA
HOGENOMiHOG000243508
KOiK01462
OMAiDGFHARV

Family and domain databases

CDDicd00487 Pep_deformylase, 1 hit
Gene3Di3.90.45.10, 1 hit
HAMAPiMF_00163 Pep_deformylase, 1 hit
InterProiView protein in InterPro
IPR023635 Peptide_deformylase
IPR036821 Peptide_deformylase_sf
PANTHERiPTHR10458 PTHR10458, 1 hit
PfamiView protein in Pfam
PF01327 Pep_deformylase, 1 hit
PIRSFiPIRSF004749 Pep_def, 1 hit
PRINTSiPR01576 PDEFORMYLASE
SUPFAMiSSF56420 SSF56420, 1 hit
TIGRFAMsiTIGR00079 pept_deformyl, 1 hit

Sequencei

Sequence statusi: Complete.

Q8PCN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIREIIRMGD KRLLRVAPPV TNLGSDELHA LVADMFETMD AARGVGLAAP
60 70 80 90 100
QIAVDLQLMV FGFEASERYP EAPAVPRTAL ANVQIEPLSD EMENGWEGCL
110 120 130 140 150
SIPGLRAVIP RHRVIRYSGF APDGTPIERE AEGFHARVVQ HEYDHLVGRL
160 170
YPSRIENFDT FGFEDVLSYD L
Length:171
Mass (Da):19,106
Last modified:October 1, 2002 - v1
Checksum:i92C65439C03E1F1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008922 Genomic DNA Translation: AAM40003.1
RefSeqiNP_636079.1, NC_003902.1
WP_011035927.1, NC_003902.1

Genome annotation databases

EnsemblBacteriaiAAM40003; AAM40003; XCC0687
GeneIDi1001340
35547143
KEGGixcc:XCC0687
PATRICifig|190485.4.peg.752

Similar proteinsi

Entry informationi

Entry nameiDEF1_XANCP
AccessioniPrimary (citable) accession number: Q8PCN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health