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Q8PC25

- MDH_XANCP

UniProt

Q8PC25 - MDH_XANCP

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Protein
Malate dehydrogenase
Gene
mdh, XCC0928
Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei94 – 941Substrate By similarity
Binding sitei100 – 1001Substrate By similarity
Binding sitei107 – 1071NAD By similarity
Binding sitei114 – 1141NAD By similarity
Binding sitei133 – 1331Substrate By similarity
Binding sitei164 – 1641Substrate By similarity
Active sitei189 – 1891Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 177NAD By similarity
Nucleotide bindingi131 – 1333NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciXCAM190485:GIXZ-927-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:XCC0928
OrganismiXanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
Taxonomic identifieri190485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000001010: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Malate dehydrogenaseUniRule annotation
PRO_0000113402Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi190485.XCC0928.

Structurei

3D structure databases

ProteinModelPortaliQ8PC25.
SMRiQ8PC25. Positions 2-328.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000220953.
KOiK00024.
OMAiHHCKVNM.
OrthoDBiEOG6PP9Q2.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8PC25-1 [UniParc]FASTAAdd to Basket

« Hide

MKAPVRVAVT GAAGQIGYAL LFRIASGEML GKDQPVILQL LELSNEKAQA    50
ALKGVMMELE DCAFPLLAGM VGTDDAEVAF KDIDVALLVG ARPRGPGMER 100
KDLLLENAKI FTAQGAALNK VAKRDVKVLV VGNPANTNAY IAMKSAPDLN 150
PKNFTAMLRL DHNRALSQLS LKLGKPVGGI EKLVVWGNHS PTMYPDYRFA 200
TSDGASIGDA INDQEWNAGT FIPTVGKRGA AIIEARGLSS AASAANAAID 250
HVRDWVLGSN GKWVTMGVPS DGSYGIPEGV IFGFPVTTEN GQYTLVKDLP 300
IDDFSQKYID KTLAELEEER SGVSHLLG 328
Length:328
Mass (Da):34,935
Last modified:October 1, 2002 - v1
Checksum:i0CC5DE99D0DD863F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008922 Genomic DNA. Translation: AAM40238.1.
RefSeqiNP_636314.1. NC_003902.1.

Genome annotation databases

EnsemblBacteriaiAAM40238; AAM40238; XCC0928.
GeneIDi1001478.
KEGGixcc:XCC0928.
PATRICi24072541. VBIXanCam115730_1000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008922 Genomic DNA. Translation: AAM40238.1 .
RefSeqi NP_636314.1. NC_003902.1.

3D structure databases

ProteinModelPortali Q8PC25.
SMRi Q8PC25. Positions 2-328.
ModBasei Search...

Protein-protein interaction databases

STRINGi 190485.XCC0928.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM40238 ; AAM40238 ; XCC0928 .
GeneIDi 1001478.
KEGGi xcc:XCC0928.
PATRICi 24072541. VBIXanCam115730_1000.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000220953.
KOi K00024.
OMAi HHCKVNM.
OrthoDBi EOG6PP9Q2.

Enzyme and pathway databases

BioCyci XCAM190485:GIXZ-927-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_01517. Malate_dehydrog_2.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23382. PTHR23382. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
ProtoNeti Search...

Entry informationi

Entry nameiMDH_XANCP
AccessioniPrimary (citable) accession number: Q8PC25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2002
Last modified: May 14, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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