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Protein

3-oxoacyl-[acyl-carrier-protein] synthase 3

Gene

fabH

Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.UniRule annotation

Catalytic activityi

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2.UniRule annotation

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei116UniRule annotation1
Active sitei252UniRule annotation1
Active sitei282UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Multifunctional enzyme, Transferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciXCAM190485:G1FZM-1015-MONOMER
UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3UniRule annotation (EC:2.3.1.180UniRule annotation)
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase IIIUniRule annotation
Beta-ketoacyl-ACP synthase IIIUniRule annotation
Short name:
KAS IIIUniRule annotation
Gene namesi
Name:fabHUniRule annotation
Ordered Locus Names:XCC1016
OrganismiXanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Taxonomic identifieri190485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000001010 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001105121 – 3253-oxoacyl-[acyl-carrier-protein] synthase 3Add BLAST325

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi190485.XCC1016

Structurei

3D structure databases

ProteinModelPortaliQ8PBV1
SMRiQ8PBV1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni253 – 257ACP-bindingUniRule annotation5

Domaini

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.UniRule annotation

Sequence similaritiesi

Belongs to the FabH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CCZ Bacteria
COG0332 LUCA
HOGENOMiHOG000246674
KOiK00648
OMAiIGPTVWG

Family and domain databases

Gene3Di3.40.47.10, 1 hit
HAMAPiMF_01815 FabH, 1 hit
InterProiView protein in InterPro
IPR013751 ACP_syn_III
IPR013747 ACP_syn_III_C
IPR004655 FabH_synth
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF08545 ACP_syn_III, 1 hit
PF08541 ACP_syn_III_C, 1 hit
SUPFAMiSSF53901 SSF53901, 1 hit
TIGRFAMsiTIGR00747 fabH, 1 hit

Sequencei

Sequence statusi: Complete.

Q8PBV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKRIYSRIA GTGSYLPEKV LTNDDMSKIV DTSDEWIRSR TGIRERHIVA
60 70 80 90 100
DDQTTSDLAY FASLKAMEAA GVTADEIDLI VVGTTTPDLI FPSTACLLQA
110 120 130 140 150
RLGNVGCGAF DVNAACSGFV YALSVADKFV RSGDAKTVLV VGAETLTRIV
160 170 180 190 200
DWTDRTTCVL FGDGAGAVVL KADEDTGILS THLHADGSKK ELLWDPVGVS
210 220 230 240 250
VGFGEGKNGG GALLMKGNDV FKYAVKALDS VVDETLAANG LDTHDLDWLI
260 270 280 290 300
PHQANLRIIE ATAKRLDLPM EQVVVTVDRH GNTSSASVPL ALDEAVRSGR
310 320
VQRGQLLLLE AFGGGFTWGS ALLRY
Length:325
Mass (Da):34,676
Last modified:October 1, 2002 - v1
Checksum:i77BC35F1933ED701
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008922 Genomic DNA Translation: AAM40316.1
RefSeqiNP_636392.1, NC_003902.1
WP_011036218.1, NC_003902.1

Genome annotation databases

EnsemblBacteriaiAAM40316; AAM40316; XCC1016
GeneIDi35546734
999363
KEGGixcc:XCC1016
PATRICifig|190485.4.peg.1081

Similar proteinsi

Entry informationi

Entry nameiFABH_XANCP
AccessioniPrimary (citable) accession number: Q8PBV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health