Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ADP-dependent (S)-NAD(P)H-hydrate dehydratase

Gene

nnrD

Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.UniRule annotation

Catalytic activityi

ADP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine-dinucleotide = AMP + phosphate + NADH.UniRule annotation
ADP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine-dinucleotide phosphate = AMP + phosphate + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei114NAD(P)HX; via amide nitrogenUniRule annotation1
Binding sitei227NAD(P)HXUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi197 – 201ADPUniRule annotation5
Nucleotide bindingi217 – 226ADPUniRule annotation10

GO - Molecular functioni

Keywordsi

Molecular functionLyase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciXCAM190485:XCC1076-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-dependent (S)-NAD(P)H-hydrate dehydrataseUniRule annotation (EC:4.2.1.136UniRule annotation)
Alternative name(s):
ADP-dependent NAD(P)HX dehydrataseUniRule annotation
Gene namesi
Name:nnrDUniRule annotation
Ordered Locus Names:XCC1076
OrganismiXanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Taxonomic identifieri190485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000001010 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004161511 – 289ADP-dependent (S)-NAD(P)H-hydrate dehydrataseAdd BLAST289

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi190485.XCC1076

Structurei

3D structure databases

ProteinModelPortaliQ8PBP3
SMRiQ8PBP3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 286YjeF C-terminalUniRule annotationAdd BLAST278

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni160 – 166NAD(P)HXUniRule annotation7

Sequence similaritiesi

Belongs to the NnrD/CARKD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107Z4K Bacteria
COG0063 LUCA
HOGENOMiHOG000024581
KOiK17758
OMAiNLMVHPL

Family and domain databases

CDDicd01171 YXKO-related, 1 hit
Gene3Di3.40.1190.20, 1 hit
HAMAPiMF_01965 NADHX_dehydratase, 1 hit
InterProiView protein in InterPro
IPR000631 CARKD
IPR029056 Ribokinase-like
PfamiView protein in Pfam
PF01256 Carb_kinase, 1 hit
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00196 yjeF_cterm, 1 hit
PROSITEiView protein in PROSITE
PS51383 YJEF_C_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8PBP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGPRVRTVT AAALRAQPLP APGGDKEQRG RVLIVGGSAR VPGAVMLAGE
60 70 80 90 100
AALRAGAGKL QLATAASVAP GMALAMPEAL VLGLGENGQG EIVRGHRALD
110 120 130 140 150
AAMSACDAAV IGPGMASTNT TAALVKRAID QAVCTLVLDA GALSPRLRAP
160 170 180 190 200
LGRPFVLTPH AGEMAALAGD DKAAVEAAPA DYALAFAKKM RSVVIVKGAD
210 220 230 240 250
SFVAGPDGAL WVHRGGVPGL GTSGSGDTLA GLIAGFAARG CDALTAALWG
260 270 280
VFVHATAGKQ LAKRIGTVGF LAREIPPEVP GILDRLPRG
Length:289
Mass (Da):28,802
Last modified:October 1, 2002 - v1
Checksum:i1DCB9E4EE0C5A2C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008922 Genomic DNA Translation: AAM40375.1
RefSeqiNP_636451.1, NC_003902.1
WP_011036276.1, NC_003902.1

Genome annotation databases

EnsemblBacteriaiAAM40375; AAM40375; XCC1076
GeneIDi35546655
998493
KEGGixcc:XCC1076
PATRICifig|190485.4.peg.1144

Similar proteinsi

Entry informationi

Entry nameiNNRD_XANCP
AccessioniPrimary (citable) accession number: Q8PBP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health