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Q8PBK7

- GCSP_XANCP

UniProt

Q8PBK7 - GCSP_XANCP

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, XCC1112
Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciXCAM190485:GIXZ-1111-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:XCC1112
OrganismiXanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
Taxonomic identifieri190485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000001010: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 975975Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_0000166949Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei702 – 7021N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi190485.XCC1112.

Structurei

3D structure databases

ProteinModelPortaliQ8PBK7.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiERRDICL.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8PBK7-1 [UniParc]FASTAAdd to Basket

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MSQTPSSLRD LEHHSAFVER HIGPNDAEIA QMLGVVGHDS LDAMTDAIVP    50
SNIKSPAALA LPDAITEEEA LARIRAIASK NQVQRTFIGQ GYYGTHTPKV 100
ILRNILENPA WYTAYTPYQA EISQGRMEAL INFQTMCADL TGMQIANASL 150
LDEATAAAEA MTLAKRSAKS KSDTFFVHDA VHPQTQELLR TRAEPLGIVL 200
RVGTPDEAMQ AECFGVLLQY PDSFGHIGDH AALADAVHAQ GGLVAVATDL 250
LALTLIAAPG EWGADIVVGN SQRFGVPFGF GGPHAAFMAC RDAYKRSMPG 300
RLIGVSIDAA GNPAYRLTLQ TREQHIRREK ATSNICTAQV LLAVMASMYA 350
VYHGPEGLTR IARRTHRLAA ILAAALRSAG VTVGEHFFDT LHVKAIDADA 400
IHAKAHAAGI NLRAIDSEAV GISLDETSTR ADVVALAQLF GAQADIDALD 450
AATADALPQG MRRTSAFLQH PVFNTHHSEH ELLRYMRSLA DKDLAMDRTM 500
IPLGSCTMKL NATAEMIPVT WPEFGAIHPL APPEQSAGYA QLIEELEAML 550
VECTGYDAVS LQPNSGAQGE YAGLLAIRAY HRSRNEAHRD ICLIPESAHG 600
TNPASAQMCG MTVVVTKCDA NGNVDVDDIR AKAEKYSDRL AALMITYPST 650
HGVFEEDVVA ICEAVHAHGG QVYTDGANMN ALVGVAKPGK WGSDVSHLNL 700
HKTFCIPHGG GGPGVGPCAV KSHLAPFLPK TLPNAGIRAG ENQKAAIHGS 750
GSNFGEGEVG MVSAASYGSA SILPISWMYV TMMGSAGLRK ATQVALLNAN 800
YIAKRLSAHY KTLYTGRNGL VAHECILDVR PLEKTSGIGA EDIAKRLIDF 850
GFHAPTLSFP VAGTLMVEPT ESESQHELDR FIDAMIQIRE EIRAIEDGRL 900
DREDNPLKHA PHTATQVSAS EWTHAYPREL AAFPLPSLKQ QKYWPPVGRV 950
DNVYGDKNVM CACIPVDAYK DDVVA 975
Length:975
Mass (Da):104,719
Last modified:October 1, 2002 - v1
Checksum:i7E55F8591F3654B2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008922 Genomic DNA. Translation: AAM40411.1.
RefSeqiNP_636487.1. NC_003902.1.
WP_011036312.1. NC_003902.1.

Genome annotation databases

EnsemblBacteriaiAAM40411; AAM40411; XCC1112.
GeneIDi1001025.
KEGGixcc:XCC1112.
PATRICi24072940. VBIXanCam115730_1188.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008922 Genomic DNA. Translation: AAM40411.1 .
RefSeqi NP_636487.1. NC_003902.1.
WP_011036312.1. NC_003902.1.

3D structure databases

ProteinModelPortali Q8PBK7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 190485.XCC1112.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM40411 ; AAM40411 ; XCC1112 .
GeneIDi 1001025.
KEGGi xcc:XCC1112.
PATRICi 24072940. VBIXanCam115730_1188.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi ERRDICL.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci XCAM190485:GIXZ-1111-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Entry informationi

Entry nameiGCSP_XANCP
AccessioniPrimary (citable) accession number: Q8PBK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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