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Q8PBK7 (GCSP_XANCP) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:XCC1112
OrganismXanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568) [Reference proteome] [HAMAP]
Taxonomic identifier190485 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

Protein attributes

Sequence length975 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 975975Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000166949

Amino acid modifications

Modified residue7021N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8PBK7 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 7E55F8591F3654B2

FASTA975104,719
        10         20         30         40         50         60 
MSQTPSSLRD LEHHSAFVER HIGPNDAEIA QMLGVVGHDS LDAMTDAIVP SNIKSPAALA 

        70         80         90        100        110        120 
LPDAITEEEA LARIRAIASK NQVQRTFIGQ GYYGTHTPKV ILRNILENPA WYTAYTPYQA 

       130        140        150        160        170        180 
EISQGRMEAL INFQTMCADL TGMQIANASL LDEATAAAEA MTLAKRSAKS KSDTFFVHDA 

       190        200        210        220        230        240 
VHPQTQELLR TRAEPLGIVL RVGTPDEAMQ AECFGVLLQY PDSFGHIGDH AALADAVHAQ 

       250        260        270        280        290        300 
GGLVAVATDL LALTLIAAPG EWGADIVVGN SQRFGVPFGF GGPHAAFMAC RDAYKRSMPG 

       310        320        330        340        350        360 
RLIGVSIDAA GNPAYRLTLQ TREQHIRREK ATSNICTAQV LLAVMASMYA VYHGPEGLTR 

       370        380        390        400        410        420 
IARRTHRLAA ILAAALRSAG VTVGEHFFDT LHVKAIDADA IHAKAHAAGI NLRAIDSEAV 

       430        440        450        460        470        480 
GISLDETSTR ADVVALAQLF GAQADIDALD AATADALPQG MRRTSAFLQH PVFNTHHSEH 

       490        500        510        520        530        540 
ELLRYMRSLA DKDLAMDRTM IPLGSCTMKL NATAEMIPVT WPEFGAIHPL APPEQSAGYA 

       550        560        570        580        590        600 
QLIEELEAML VECTGYDAVS LQPNSGAQGE YAGLLAIRAY HRSRNEAHRD ICLIPESAHG 

       610        620        630        640        650        660 
TNPASAQMCG MTVVVTKCDA NGNVDVDDIR AKAEKYSDRL AALMITYPST HGVFEEDVVA 

       670        680        690        700        710        720 
ICEAVHAHGG QVYTDGANMN ALVGVAKPGK WGSDVSHLNL HKTFCIPHGG GGPGVGPCAV 

       730        740        750        760        770        780 
KSHLAPFLPK TLPNAGIRAG ENQKAAIHGS GSNFGEGEVG MVSAASYGSA SILPISWMYV 

       790        800        810        820        830        840 
TMMGSAGLRK ATQVALLNAN YIAKRLSAHY KTLYTGRNGL VAHECILDVR PLEKTSGIGA 

       850        860        870        880        890        900 
EDIAKRLIDF GFHAPTLSFP VAGTLMVEPT ESESQHELDR FIDAMIQIRE EIRAIEDGRL 

       910        920        930        940        950        960 
DREDNPLKHA PHTATQVSAS EWTHAYPREL AAFPLPSLKQ QKYWPPVGRV DNVYGDKNVM 

       970 
CACIPVDAYK DDVVA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008922 Genomic DNA. Translation: AAM40411.1.
RefSeqNP_636487.1. NC_003902.1.

3D structure databases

ProteinModelPortalQ8PBK7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING190485.XCC1112.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM40411; AAM40411; XCC1112.
GeneID1001025.
KEGGxcc:XCC1112.
PATRIC24072940. VBIXanCam115730_1188.

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAIRVQVII.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycXCAM190485:GIXZ-1111-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_XANCP
AccessionPrimary (citable) accession number: Q8PBK7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: October 1, 2002
Last modified: February 19, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families