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Protein

Catalase-peroxidase

Gene

katG

Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei89Transition state stabilizerUniRule annotation1
Active sitei93Proton acceptorUniRule annotation1
Metal bindingi279Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciXCAM190485:G1FZM-1204-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:XCC1205
OrganismiXanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Taxonomic identifieri190485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000001010 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003549551 – 748Catalase-peroxidaseAdd BLAST748

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki92 ↔ 238Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-264)UniRule annotation
Cross-linki238 ↔ 264Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-92)UniRule annotation

Post-translational modificationi

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi190485.XCC1205

Structurei

3D structure databases

ProteinModelPortaliQ8PBB7
SMRiQ8PBB7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X Bacteria
COG0376 LUCA
HOGENOMiHOG000218110
KOiK03782
OMAiPEEDIYW

Family and domain databases

HAMAPiMF_01961 Catal_peroxid, 1 hit
InterProiView protein in InterPro
IPR000763 Catalase_peroxidase
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
PANTHERiPTHR30555 PTHR30555, 1 hit
PfamiView protein in Pfam
PF00141 peroxidase, 2 hits
PRINTSiPR00460 BPEROXIDASE
PR00458 PEROXIDASE
SUPFAMiSSF48113 SSF48113, 2 hits
TIGRFAMsiTIGR00198 cat_per_HPI, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Q8PBB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTEAKCPFN HSVVGAGTTN RDWWPKQLRV DLLNQHSARS NPLAASFNYA
60 70 80 90 100
EAFKRLDLQT LKQELRALMT DSQDWWPADF GHYGPLFVRM AWHSAGTYRT
110 120 130 140 150
GDGRGGGGRG QQRFAPLNSW PDNVSLDKAR RLLWPIKQKY GQAISWADLM
160 170 180 190 200
ILTGNVALES MGFKTFGFAG GREDTWEPDQ DLYWGRETKW LGGDDRYAHG
210 220 230 240 250
SPGVDQAHGV LVKDDDSEVQ HTRDLENPLA AVQMGLIYVN PEGPDGNPDP
260 270 280 290 300
LLAAKDIRDT FGRMAMNDEE TVALIAGGHT FGKTHGAADA AHVAAEPEAS
310 320 330 340 350
DLESQGLGWH NSFGSGKGGD TITSGLEVTW TTTPAQWSND FFDHLFGFEW
360 370 380 390 400
ELSKSPAGAH QWVAKNAQAI IPDAHDASKK RLPTMLTTDL ALRIDPAYEA
410 420 430 440 450
ISRRFHANPD QFADAFARAW FKLTHRDMGP RARYLGADVP AEELLWQDPI
460 470 480 490 500
PALNHALIDA QDAAALKQTV LSSGLSVAQL VATAWASASS FRGSDKRGGA
510 520 530 540 550
NGARIRLAPQ KDWASNEPAQ LAQVLATLER IQADFNARQS GGKQISLADL
560 570 580 590 600
IVLGGNAAVE QAAHAAGHAV TVPFAPGRMD ASQAQTDVES FAVLEPVADG
610 620 630 640 650
FRNYAKARYA VSAEALLIDK AQLLTLTAPE MTVLVGGLRV LGANTGQSHN
660 670 680 690 700
GVFTTRPGVL SNDFFANLLD MRTEWKATSE TKETYEGRDR ATGEHKWTGT
710 720 730 740
RVDLVFGSNS ILRAVAEVYA SADAQEKFVQ DFVAAWTKVM QLDRFDLA
Length:748
Mass (Da):81,593
Last modified:October 1, 2002 - v1
Checksum:i823A7AB8BE3D9C57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008922 Genomic DNA Translation: AAM40503.1
RefSeqiNP_636579.1, NC_003902.1
WP_011036402.1, NC_003902.1

Genome annotation databases

EnsemblBacteriaiAAM40503; AAM40503; XCC1205
GeneIDi1001115
35543897
KEGGixcc:XCC1205
PATRICifig|190485.4.peg.1295

Similar proteinsi

Entry informationi

Entry nameiKATG_XANCP
AccessioniPrimary (citable) accession number: Q8PBB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health