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Q8PAW6

- LPXB_XANCP

UniProt

Q8PAW6 - LPXB_XANCP

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, XCC1360
Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciXCAM190485:GIXZ-1358-MONOMER.
UniPathwayiUPA00359; UER00481.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:XCC1360
OrganismiXanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
Taxonomic identifieri190485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000001010: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 438438Lipid-A-disaccharide synthaseUniRule annotation
PRO_0000190194Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi190485.XCC1360.

Structurei

3D structure databases

ProteinModelPortaliQ8PAW6.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8PAW6-1 [UniParc]FASTAAdd to Basket

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MTGIGNREPE HGAGAHVGAA VSVPDAASIP HSPLPIPGAR MRAPRIALIA    50
GEASGDILGA GLIDALRRRY PDAEFVGIGG DAMRSAGCQT WFDASELAVM 100
GLTEVLRHLP RLLKLRSAFR ERVLAWKPDV FIGIDAPDFN LPVERWLKQR 150
GVRTVHYVSP SVWAWREKRA EKIGVSADLV LCLFPMEPPI YAKHGVDARF 200
VGHPMADAIA YQADREAARA KLGLSTSSTV LAVLPGSRHG EISRLGDTFF 250
QAAWLVSEHL PNLHVLVPAA NPGCKQLLAE QLSRSSLPVM RSHLLDGQAR 300
TAMLAADVVL LASGTATLEA MLVKRPMVVG YKVAPLTYRI VKTLGLLKVN 350
RYALPNILAN EDLAPELMQD DCTPERLCEA LLDWFKHPEK VAGLQSRYLA 400
LHAQLRQDAS ARAAEAVAEL LTQRELGIGN RESGGAGS 438
Length:438
Mass (Da):47,373
Last modified:October 31, 2006 - v2
Checksum:i57F54210F9AF7125
GO

Sequence cautioni

The sequence AAM40658.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008922 Genomic DNA. Translation: AAM40658.1. Different initiation.
RefSeqiNP_636734.1. NC_003902.1.

Genome annotation databases

EnsemblBacteriaiAAM40658; AAM40658; XCC1360.
GeneIDi1001765.
KEGGixcc:XCC1360.
PATRICi24073491. VBIXanCam115730_1462.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008922 Genomic DNA. Translation: AAM40658.1 . Different initiation.
RefSeqi NP_636734.1. NC_003902.1.

3D structure databases

ProteinModelPortali Q8PAW6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 190485.XCC1360.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM40658 ; AAM40658 ; XCC1360 .
GeneIDi 1001765.
KEGGi xcc:XCC1360.
PATRICi 24073491. VBIXanCam115730_1462.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci XCAM190485:GIXZ-1358-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Entry informationi

Entry nameiLPXB_XANCP
AccessioniPrimary (citable) accession number: Q8PAW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: October 31, 2006
Last modified: May 14, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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