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Q8PAW6 (LPXB_XANCP) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:XCC1360
OrganismXanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568) [Reference proteome] [HAMAP]
Taxonomic identifier190485 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

Protein attributes

Sequence length438 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

Belongs to the LpxB family.

Sequence caution

The sequence AAM40658.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 438438Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_0000190194

Sequences

Sequence LengthMass (Da)Tools
Q8PAW6 [UniParc].

Last modified October 31, 2006. Version 2.
Checksum: 57F54210F9AF7125

FASTA43847,373
        10         20         30         40         50         60 
MTGIGNREPE HGAGAHVGAA VSVPDAASIP HSPLPIPGAR MRAPRIALIA GEASGDILGA 

        70         80         90        100        110        120 
GLIDALRRRY PDAEFVGIGG DAMRSAGCQT WFDASELAVM GLTEVLRHLP RLLKLRSAFR 

       130        140        150        160        170        180 
ERVLAWKPDV FIGIDAPDFN LPVERWLKQR GVRTVHYVSP SVWAWREKRA EKIGVSADLV 

       190        200        210        220        230        240 
LCLFPMEPPI YAKHGVDARF VGHPMADAIA YQADREAARA KLGLSTSSTV LAVLPGSRHG 

       250        260        270        280        290        300 
EISRLGDTFF QAAWLVSEHL PNLHVLVPAA NPGCKQLLAE QLSRSSLPVM RSHLLDGQAR 

       310        320        330        340        350        360 
TAMLAADVVL LASGTATLEA MLVKRPMVVG YKVAPLTYRI VKTLGLLKVN RYALPNILAN 

       370        380        390        400        410        420 
EDLAPELMQD DCTPERLCEA LLDWFKHPEK VAGLQSRYLA LHAQLRQDAS ARAAEAVAEL 

       430 
LTQRELGIGN RESGGAGS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008922 Genomic DNA. Translation: AAM40658.1. Different initiation.
RefSeqNP_636734.1. NC_003902.1.

3D structure databases

ProteinModelPortalQ8PAW6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING190485.XCC1360.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM40658; AAM40658; XCC1360.
GeneID1001765.
KEGGxcc:XCC1360.
PATRIC24073491. VBIXanCam115730_1462.

Phylogenomic databases

eggNOGCOG0763.
HOGENOMHOG000018003.
KOK00748.
OMAYIAPQEW.
OrthoDBEOG6FBWZR.
ProtClustDBPRK00025.

Enzyme and pathway databases

BioCycXCAM190485:GIXZ-1358-MONOMER.
UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
[Graphical view]
PfamPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_XANCP
AccessionPrimary (citable) accession number: Q8PAW6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: October 31, 2006
Last modified: February 19, 2014
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways