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Protein

NAD kinase

Gene

nadK

Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei45Proton acceptorUniRule annotation1
Binding sitei147NADUniRule annotation1
Binding sitei155NAD; via carbonyl oxygenUniRule annotation1
Binding sitei182NAD; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi45 – 46NADUniRule annotation2
Nucleotide bindingi117 – 118NADUniRule annotation2
Nucleotide bindingi158 – 163NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciXCAM190485:G1FZM-1544-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:XCC1546
OrganismiXanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Taxonomic identifieri190485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000001010 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001206921 – 258NAD kinaseAdd BLAST258

Interactioni

Protein-protein interaction databases

STRINGi190485.XCC1546

Structurei

3D structure databases

ProteinModelPortaliQ8PAD9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000139847
KOiK00858
OMAiNGIERMS

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q8PAD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAMPRIAFL ASPAEPAVAA RARLVQRYGD HALHDADIVC ALGGDGFMLQ
60 70 80 90 100
TLHRHGAADK PVFGMKLGSV GFLMNQYRDD EDDLLARLQR AEPAHLRPLE
110 120 130 140 150
MLVQTESGTS AGSLAYNEVS LLRQTRQAAH LSVDLNGQTR IAELIGDGVM
160 170 180 190 200
VATPAGSTAY NYSAHGPILP LGSHTLALTP IAPYRPRRWR GAILKADTEV
210 220 230 240 250
RFRVLDPYKR PVSVTADSHE IRDVVEVTIR ESTERRVTLL FDPEHNLEER

IFSEQFAV
Length:258
Mass (Da):28,471
Last modified:October 25, 2002 - v1
Checksum:i49968EA806F408EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008922 Genomic DNA Translation: AAM40841.1
RefSeqiNP_636917.1, NC_003902.1
WP_011036730.1, NC_003902.1

Genome annotation databases

EnsemblBacteriaiAAM40841; AAM40841; XCC1546
GeneIDi35547677
998916
KEGGixcc:XCC1546
PATRICifig|190485.4.peg.1659

Similar proteinsi

Entry informationi

Entry nameiNADK_XANCP
AccessioniPrimary (citable) accession number: Q8PAD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 25, 2002
Last modified: March 28, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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