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Protein

Imidazole glycerol phosphate synthase subunit HisH

Gene

hisH

Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR.UniRule annotation

Catalytic activityi

5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H2O.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Histidine biosynthesis bifunctional protein HisB (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. Histidine biosynthesis bifunctional protein HisB (hisB)
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei78NucleophileUniRule annotation1
Active sitei179UniRule annotation1
Active sitei181UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processAmino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

BioCyciXCAM190485:XCC1812-MONOMER
UniPathwayiUPA00031; UER00010

Names & Taxonomyi

Protein namesi
Recommended name:
Imidazole glycerol phosphate synthase subunit HisHUniRule annotation (EC:2.4.2.-UniRule annotation)
Alternative name(s):
IGP synthase glutamine amidotransferase subunitUniRule annotation
IGP synthase subunit HisHUniRule annotation
ImGP synthase subunit HisHUniRule annotation
Short name:
IGPS subunit HisHUniRule annotation
Gene namesi
Name:hisHUniRule annotation
Ordered Locus Names:XCC1812
OrganismiXanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Taxonomic identifieri190485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000001010 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001524491 – 200Imidazole glycerol phosphate synthase subunit HisHAdd BLAST200

Interactioni

Subunit structurei

Heterodimer of HisH and HisF.UniRule annotation

Protein-protein interaction databases

STRINGi190485.XCC1812

Structurei

3D structure databases

ProteinModelPortaliQ8P9P1
SMRiQ8P9P1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 200Glutamine amidotransferase type-1UniRule annotationAdd BLAST198

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiENOG4108UJE Bacteria
COG0118 LUCA
HOGENOMiHOG000025030
KOiK02501
OMAiWVYFVHS

Family and domain databases

CDDicd01748 GATase1_IGP_Synthase, 1 hit
Gene3Di3.40.50.880, 1 hit
HAMAPiMF_00278 HisH, 1 hit
InterProiView protein in InterPro
IPR029062 Class_I_gatase-like
IPR017926 GATASE
IPR010139 Imidazole-glycPsynth_HisH
PANTHERiPTHR42701 PTHR42701, 1 hit
PfamiView protein in Pfam
PF00117 GATase, 1 hit
PIRSFiPIRSF000495 Amidotransf_hisH, 1 hit
SUPFAMiSSF52317 SSF52317, 1 hit
TIGRFAMsiTIGR01855 IMP_synth_hisH, 1 hit
PROSITEiView protein in PROSITE
PS51273 GATASE_TYPE_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q8P9P1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDLALIDAG GANLGSVRYA LERLGVEARV VRDAQGLQGA ERVILPGVGA
60 70 80 90 100
APEAMARLRA QGLIEPLQQL QVPLIGICLG MQLLFEHSEE GDVDCLGMLP
110 120 130 140 150
GIVRHMTPAL GIRVPHMGWN QLVPMRDSAL LAGLPERASA YFVHGYAAPV
160 170 180 190 200
TADTVAACDH GGLFTAVVQS GLRCGAQFHP ERSADTGARI LRNFLEMSFP
Length:200
Mass (Da):21,260
Last modified:October 1, 2002 - v1
Checksum:iDF66887387F8A486
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008922 Genomic DNA Translation: AAM41101.1
RefSeqiNP_637177.1, NC_003902.1
WP_011036982.1, NC_003902.1

Genome annotation databases

EnsemblBacteriaiAAM41101; AAM41101; XCC1812
GeneIDi998491
KEGGixcc:XCC1812
PATRICifig|190485.4.peg.1932

Similar proteinsi

Entry informationi

Entry nameiHIS5_XANCP
AccessioniPrimary (citable) accession number: Q8P9P1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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