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Protein

Histidine biosynthesis bifunctional protein HisIE

Gene

hisI

Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-AMP + diphosphate.UniRule annotation
1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 2 and 3 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Histidine biosynthesis bifunctional protein HisB (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. Histidine biosynthesis bifunctional protein HisB (hisB)
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Multifunctional enzyme
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciXCAM190485:G1FZM-1813-MONOMER
UniPathwayiUPA00031; UER00007
UPA00031; UER00008

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine biosynthesis bifunctional protein HisIEUniRule annotation
Including the following 2 domains:
Phosphoribosyl-AMP cyclohydrolaseUniRule annotation (EC:3.5.4.19UniRule annotation)
Short name:
PRA-CHUniRule annotation
Phosphoribosyl-ATP pyrophosphataseUniRule annotation (EC:3.6.1.31UniRule annotation)
Short name:
PRA-PHUniRule annotation
Gene namesi
Name:hisIUniRule annotation
Synonyms:hisIEUniRule annotation
Ordered Locus Names:XCC1815
OrganismiXanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Taxonomic identifieri190485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000001010 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001364511 – 206Histidine biosynthesis bifunctional protein HisIEAdd BLAST206

Interactioni

Protein-protein interaction databases

STRINGi190485.XCC1815

Structurei

3D structure databases

ProteinModelPortaliQ8P9N8
SMRiQ8P9N8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 117Phosphoribosyl-AMP cyclohydrolaseAdd BLAST117
Regioni118 – 206Phosphoribosyl-ATP pyrophosphohydrolaseAdd BLAST89

Sequence similaritiesi

In the N-terminal section; belongs to the PRA-CH family.UniRule annotation
In the C-terminal section; belongs to the PRA-PH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105K8F Bacteria
COG0139 LUCA
COG0140 LUCA
HOGENOMiHOG000277503
KOiK11755
OMAiVMACKDD

Family and domain databases

CDDicd11534 NTP-PPase_HisIE_like, 1 hit
Gene3Di3.10.20.400, 1 hit
HAMAPiMF_01020 HisE, 1 hit
MF_01019 HisIE, 1 hit
InterProiView protein in InterPro
IPR023019 His_synth_HisIE
IPR008179 HisE
IPR021130 PRib-ATP_PPHydrolase-like
IPR002496 PRib_AMP_CycHydrolase_dom
IPR038019 PRib_AMP_CycHydrolase_sf
PfamiView protein in Pfam
PF01502 PRA-CH, 1 hit
PF01503 PRA-PH, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002610 PRA_CycHdrlase, 1 hit
SUPFAMiSSF141734 SSF141734, 1 hit
TIGRFAMsiTIGR03188 histidine_hisI, 1 hit

Sequencei

Sequence statusi: Complete.

Q8P9N8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSETTAAGD ALDALDWNKG DGLLPVIVQD ADNLRVLMLG YMNAEALAVT
60 70 80 90 100
RARGEVTFFS RSKQRLWTKG ESSGNVLRVV AIETDCDADT LLVQARPHGP
110 120 130 140 150
TCHLGRTSCF PTAPSQFLGS LDALIAEREH ERPHGSYTTK LFEQGIRRIA
160 170 180 190 200
QKVGEEGVET ALAGVVQGDA ELLGESADLL YHLIVLLRAR GLGLGDAVAL

LESRHK
Length:206
Mass (Da):22,175
Last modified:October 1, 2002 - v1
Checksum:i121D52530770B61C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008922 Genomic DNA Translation: AAM41104.1
RefSeqiNP_637180.1, NC_003902.1
WP_011036985.1, NC_003902.1

Genome annotation databases

EnsemblBacteriaiAAM41104; AAM41104; XCC1815
GeneIDi998473
KEGGixcc:XCC1815
PATRICifig|190485.4.peg.1935

Similar proteinsi

Entry informationi

Entry nameiHIS2_XANCP
AccessioniPrimary (citable) accession number: Q8P9N8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: October 1, 2002
Last modified: February 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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