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Q8P8K2

- PROB_XANCP

UniProt

Q8P8K2 - PROB_XANCP

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Protein
Glutamate 5-kinase
Gene
proB, XCC2239
Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei3 – 31ATP By similarity
Binding sitei43 – 431Substrate By similarity
Binding sitei128 – 1281Substrate By similarity
Binding sitei140 – 1401Substrate; via amide nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi160 – 1612ATP By similarity
Nucleotide bindingi202 – 2087ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA binding Source: InterPro
  3. glutamate 5-kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-proline biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciXCAM190485:GIXZ-2237-MONOMER.
UniPathwayiUPA00098; UER00359.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate 5-kinase (EC:2.7.2.11)
Alternative name(s):
Gamma-glutamyl kinase
Short name:
GK
Gene namesi
Name:proB
Ordered Locus Names:XCC2239
OrganismiXanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
Taxonomic identifieri190485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000001010: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362Glutamate 5-kinaseUniRule annotation
PRO_0000109758Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi190485.XCC2239.

Structurei

3D structure databases

ProteinModelPortaliQ8P8K2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini267 – 34882PUA
Add
BLAST

Sequence similaritiesi

Contains 1 PUA domain.

Phylogenomic databases

eggNOGiCOG0263.
HOGENOMiHOG000246368.
KOiK00931.
OMAiRLMRAYE.
OrthoDBiEOG6PGK7G.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
3.40.1160.10. 1 hit.
HAMAPiMF_00456. ProB.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR019797. Glutamate_5-kinase_CS.
IPR002478. PUA.
IPR015947. PUA-like_domain.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
PF01472. PUA. 1 hit.
[Graphical view]
PIRSFiPIRSF000729. GK. 1 hit.
PRINTSiPR00474. GLU5KINASE.
SMARTiSM00359. PUA. 1 hit.
[Graphical view]
SUPFAMiSSF53633. SSF53633. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR01027. proB. 1 hit.
PROSITEiPS00902. GLUTAMATE_5_KINASE. 1 hit.
PS50890. PUA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8P8K2-1 [UniParc]FASTAAdd to Basket

« Hide

MLKVGSSLLA ADGGGLSPRF ALGLAQFVSA NLAAGREVVI VSSGAVAAGR    50
AILPKAAEAG AAIAARQALA ALGQAQLIAL WQRFFERPVA QVLLTHDDLR 100
NRRRYLNARA TLGELLRLGA LPVINENDTV SVDELKLGDN DNLAAIVAAL 150
VDADALFIAT DIDGLYSADP RSNPLARPLD EVAELSAEVL AMAGGSGSSV 200
GTGGMRTKLE AAAKAGAAGI ETYLFNGRSA EVVRGLAQDR LCGTRIHAAR 250
TRIAARKYWL RHAPVEPGTI LIDAGAALAL TDKGASLLPG GVAGAEGDFR 300
RGDMVEIHLR DSVGSRCLAR GVSQYSALDV RRIARRHSRE IEPILGYSYG 350
ENVVHRDDLV VL 362
Length:362
Mass (Da):37,962
Last modified:October 1, 2002 - v1
Checksum:iEB8FB3B3525ACC00
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008922 Genomic DNA. Translation: AAM41518.1.
RefSeqiNP_637594.2. NC_003902.1.

Genome annotation databases

EnsemblBacteriaiAAM41518; AAM41518; XCC2239.
GeneIDi998826.
KEGGixcc:XCC2239.
PATRICi24075383. VBIXanCam115730_2389.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008922 Genomic DNA. Translation: AAM41518.1 .
RefSeqi NP_637594.2. NC_003902.1.

3D structure databases

ProteinModelPortali Q8P8K2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 190485.XCC2239.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM41518 ; AAM41518 ; XCC2239 .
GeneIDi 998826.
KEGGi xcc:XCC2239.
PATRICi 24075383. VBIXanCam115730_2389.

Phylogenomic databases

eggNOGi COG0263.
HOGENOMi HOG000246368.
KOi K00931.
OMAi RLMRAYE.
OrthoDBi EOG6PGK7G.

Enzyme and pathway databases

UniPathwayi UPA00098 ; UER00359 .
BioCyci XCAM190485:GIXZ-2237-MONOMER.

Family and domain databases

Gene3Di 2.30.130.10. 1 hit.
3.40.1160.10. 1 hit.
HAMAPi MF_00456. ProB.
InterProi IPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR019797. Glutamate_5-kinase_CS.
IPR002478. PUA.
IPR015947. PUA-like_domain.
[Graphical view ]
Pfami PF00696. AA_kinase. 1 hit.
PF01472. PUA. 1 hit.
[Graphical view ]
PIRSFi PIRSF000729. GK. 1 hit.
PRINTSi PR00474. GLU5KINASE.
SMARTi SM00359. PUA. 1 hit.
[Graphical view ]
SUPFAMi SSF53633. SSF53633. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsi TIGR01027. proB. 1 hit.
PROSITEi PS00902. GLUTAMATE_5_KINASE. 1 hit.
PS50890. PUA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiPROB_XANCP
AccessioniPrimary (citable) accession number: Q8P8K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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