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Protein

Argininosuccinate synthase

Gene

argG

Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei35ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei88CitrullineUniRule annotation1
Binding sitei93CitrullineUniRule annotation1
Binding sitei117ATP; via amide nitrogenUniRule annotation1
Binding sitei119AspartateUniRule annotation1
Binding sitei123AspartateUniRule annotation1
Binding sitei123CitrullineUniRule annotation1
Binding sitei124AspartateUniRule annotation1
Binding sitei127CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 17ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciXCAM190485:G1FZM-2245-MONOMER
UniPathwayiUPA00068; UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:XCC2247
OrganismiXanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Taxonomic identifieri190485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000001010 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001486671 – 397Argininosuccinate synthaseAdd BLAST397

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi190485.XCC2247

Structurei

3D structure databases

ProteinModelPortaliQ8P8J4
SMRiQ8P8J4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDH Bacteria
COG0137 LUCA
HOGENOMiHOG000230095
KOiK01940
OMAiGVGRIDM

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 2 hits
3.90.1260.10, 2 hits
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8P8J4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKDIVLAF SGGLDTSFCI PYLQERGYAV HTVFADTGGV DAEERDFIEK
60 70 80 90 100
RAAELGAASH VTVDGGPAIW EGFVKPFVWA GEGYQGQYPL LVSDRYLIVD
110 120 130 140 150
AALKRAEELG TRIIAHGCTG MGNDQVRFDL AVKALGDYQI VAPIREIQKE
160 170 180 190 200
HTQTRAYEQK YLEERGFGVR AKQKAYTINE NLLGVTMSGG EIDRWEAPGE
210 220 230 240 250
GARGWCAPRS AWPTEALTVT LKFVEGEAVA LDGKALPGAQ ILAKLNTLFA
260 270 280 290 300
QYGVGRGVYT GDTVIGLKGR IVFEAPGLIS LLTAHRALED AVLTKQQNRF
310 320 330 340 350
KPDVARKWVE LVYEGFYHDP LKTDIEAFLK SSQSKVNGEV TLETRGGRVD
360 370 380 390
AVAVRSPHLL NAKGATYAQS ADWGVEEAEG FIKLFGMSST LYAQVNR
Length:397
Mass (Da):43,371
Last modified:October 19, 2002 - v1
Checksum:i22ABCDD48FFAF3F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008922 Genomic DNA Translation: AAM41526.1
RefSeqiNP_637602.1, NC_003902.1
WP_011037391.1, NC_003902.1

Genome annotation databases

EnsemblBacteriaiAAM41526; AAM41526; XCC2247
GeneIDi1002082
35547014
KEGGixcc:XCC2247
PATRICifig|190485.4.peg.2397

Similar proteinsi

Entry informationi

Entry nameiASSY_XANCP
AccessioniPrimary (citable) accession number: Q8P8J4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health