ID   Q8P8F1_XANCP            Unreviewed;       689 AA.
AC   Q8P8F1;
DT   01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 125.
DE   RecName: Full=PAS domain S-box protein {ECO:0008006|Google:ProtNLM};
GN   OrderedLocusNames=XCC2291 {ECO:0000313|EMBL:AAM41570.1};
OS   Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB
OS   528 / LMG 568 / P 25).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xanthomonas.
OX   NCBI_TaxID=190485 {ECO:0000313|EMBL:AAM41570.1, ECO:0000313|Proteomes:UP000001010};
RN   [1] {ECO:0000313|EMBL:AAM41570.1, ECO:0000313|Proteomes:UP000001010}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25
RC   {ECO:0000313|Proteomes:UP000001010};
RX   PubMed=12024217; DOI=10.1038/417459a;
RA   da Silva A.C.R., Ferro J.A., Reinach F.C., Farah C.S., Furlan L.R.,
RA   Quaggio R.B., Monteiro-Vitorello C.B., Van Sluys M.A., Almeida N.F.Jr.,
RA   Alves L.M.C., do Amaral A.M., Bertolini M.C., Camargo L.E.A., Camarotte G.,
RA   Cannavan F., Cardozo J., Chambergo F., Ciapina L.P., Cicarelli R.M.B.,
RA   Coutinho L.L., Cursino-Santos J.R., El-Dorry H., Faria J.B.,
RA   Ferreira A.J.S., Ferreira R.C.C., Ferro M.I.T., Formighieri E.F.,
RA   Franco M.C., Greggio C.C., Gruber A., Katsuyama A.M., Kishi L.T.,
RA   Leite R.P.Jr., Lemos E.G.M., Lemos M.V.F., Locali E.C., Machado M.A.,
RA   Madeira A.M.B.N., Martinez-Rossi N.M., Martins E.C., Meidanis J.,
RA   Menck C.F.M., Miyaki C.Y., Moon D.H., Moreira L.M., Novo M.T.M.,
RA   Okura V.K., Oliveira M.C., Oliveira V.R., Pereira H.A.Jr., Rossi A.,
RA   Sena J.A.D., Silva C., de Souza R.F., Spinola L.A.F., Takita M.A.,
RA   Tamura R.E., Teixeira E.C., Tezza R.I.D., Trindade dos Santos M.,
RA   Truffi D., Tsai S.M., White F.F., Setubal J.C., Kitajima J.P.;
RT   "Comparison of the genomes of two Xanthomonas pathogens with differing host
RT   specificities.";
RL   Nature 417:459-463(2002).
RN   [2] {ECO:0007829|PDB:4F3H, ECO:0007829|PDB:4F48}
RP   X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 437-684 IN COMPLEX WITH CYCLIC
RP   DIGUANOSINE MONOPHOSPHATE.
RX   PubMed=22993092; DOI=10.1107/S0907444912030594;
RA   Chin K.-H., Kou W.-T., Yu Y.-J., Liao Y.-T., Yang M.T., Chou S.-H.;
RT   "Structural polymorphism of c-di-GMP bound to an EAL domain and in complex
RT   with a type II PilZ-domain protein.";
RL   Acta Crystallogr. D 68:1380-1392(2012).
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DR   EMBL; AE008922; AAM41570.1; -; Genomic_DNA.
DR   RefSeq; NP_637646.1; NC_003902.1.
DR   RefSeq; WP_011037435.1; NC_003902.1.
DR   PDB; 4F3H; X-ray; 2.50 A; A=437-684.
DR   PDB; 4F48; X-ray; 3.00 A; A=437-684.
DR   PDBsum; 4F3H; -.
DR   PDBsum; 4F48; -.
DR   AlphaFoldDB; Q8P8F1; -.
DR   SMR; Q8P8F1; -.
DR   STRING; 190485.XCC2291; -.
DR   EnsemblBacteria; AAM41570; AAM41570; XCC2291.
DR   KEGG; xcc:XCC2291; -.
DR   PATRIC; fig|190485.4.peg.2441; -.
DR   eggNOG; COG0745; Bacteria.
DR   eggNOG; COG2199; Bacteria.
DR   eggNOG; COG2200; Bacteria.
DR   HOGENOM; CLU_000445_70_50_6; -.
DR   OrthoDB; 7052318at2; -.
DR   Proteomes; UP000001010; Chromosome.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   CDD; cd01948; EAL; 1.
DR   CDD; cd01949; GGDEF; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.20.20.450; EAL domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   NCBIfam; TIGR00229; sensory_box; 1.
DR   PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR   PANTHER; PTHR33121:SF82; FIMX; 1.
DR   Pfam; PF00563; EAL; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   SMART; SM00052; EAL; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SUPFAM; SSF141868; EAL domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR   PROSITE; PS50883; EAL; 1.
DR   PROSITE; PS50887; GGDEF; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:4F3H, ECO:0007829|PDB:4F48};
KW   Nucleotide-binding {ECO:0007829|PDB:4F3H, ECO:0007829|PDB:4F48};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001010}.
FT   DOMAIN          299..431
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          442..689
FT                   /note="EAL"
FT                   /evidence="ECO:0000259|PROSITE:PS50883"
FT   BINDING         480
FT                   /ligand="3',3'-c-di-GMP"
FT                   /ligand_id="ChEBI:CHEBI:58805"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0007829|PDB:4F3H"
FT   BINDING         481
FT                   /ligand="3',3'-c-di-GMP"
FT                   /ligand_id="ChEBI:CHEBI:58805"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0007829|PDB:4F48"
FT   BINDING         481
FT                   /ligand="3',3'-c-di-GMP"
FT                   /ligand_id="ChEBI:CHEBI:58805"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0007829|PDB:4F3H"
FT   BINDING         490
FT                   /ligand="3',3'-c-di-GMP"
FT                   /ligand_id="ChEBI:CHEBI:58805"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0007829|PDB:4F3H"
FT   BINDING         508
FT                   /ligand="3',3'-c-di-GMP"
FT                   /ligand_id="ChEBI:CHEBI:58805"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0007829|PDB:4F3H"
FT   BINDING         534
FT                   /ligand="3',3'-c-di-GMP"
FT                   /ligand_id="ChEBI:CHEBI:58805"
FT                   /ligand_label="2"
FT                   /ligand_note="covalent"
FT                   /evidence="ECO:0007829|PDB:4F3H"
FT   BINDING         653
FT                   /ligand="3',3'-c-di-GMP"
FT                   /ligand_id="ChEBI:CHEBI:58805"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0007829|PDB:4F3H"
FT   BINDING         654
FT                   /ligand="3',3'-c-di-GMP"
FT                   /ligand_id="ChEBI:CHEBI:58805"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0007829|PDB:4F3H"
SQ   SEQUENCE   689 AA;  76026 MW;  C62FD2B62C18E793 CRC64;
     MQKGKDLTLR LMIVDDSVES AEAIVTALRN GGIAVRPSRP QTPEELGSML SGQIDLAVQG
     QAQQIPMSAL QQQIAGSGKD IPIIQLADRI EENALVEAAA HGVRAIALRH RTEHLLALVR
     SEWADLQARR GLRRIEAQMR ETERRCDALI ASSRDPIAYV HEGMHIRANE AYLEMFGFES
     FEDVEGVSLL DMIAAQYVDD FKQLLKALSK GEPPPAQYKV DARRLEGDTF PATMEFATAT
     YEGEPCIQVV FRRREEFDPE LAREVEDLRQ RDQVTGLLNR PTFMVALEQA VAQAGRSEGQ
     SGFLLIEPDH YARILPEIGL DSADALIASL AAHLASVLDD SVVAARFGEH SFALLMDGNY
     ARSHALAELV RDAFAQHVFS VGERSATVTV SIGGVQIGEK IASIGQVLNR GTEAVRTTAE
     LGGNAVSIFD PAAADRAEEE RIERWVEQLR EALIGDGFLL HYQPVLNLQG EPLELYQAFL
     RLERNGEMMS PNAFMAIAEE HDLITEIDRW VVARAIRQLG ERQRAGHKTH LLVRIGPNSF
     SDPQMIDTIR EQLAVYGVPG ERLWLQTPES KVFTHLRNAQ QFLASVSAMG CKVGLEQFGS
     GLDSFQLLAH FQPAFLKLDR SITGDIASAR ESQEKIREIT SRAQPTGILT VAEFVADAQS
     MSSFFTAGVD YVQGDFVAPT GPLMNYEFG
//