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Protein

Tryptophan synthase alpha chain

Gene

trpA

Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.UniRule annotation

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei53Proton acceptorUniRule annotation1
Active sitei64Proton acceptorUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciXCAM190485:G1FZM-2539-MONOMER
UniPathwayiUPA00035; UER00044

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase alpha chainUniRule annotation (EC:4.2.1.20UniRule annotation)
Gene namesi
Name:trpAUniRule annotation
Ordered Locus Names:XCC2541
OrganismiXanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Taxonomic identifieri190485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000001010 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000988761 – 272Tryptophan synthase alpha chainAdd BLAST272

Proteomic databases

PRIDEiQ8P7S0

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.UniRule annotation

Protein-protein interaction databases

STRINGi190485.XCC2541

Structurei

3D structure databases

ProteinModelPortaliQ8P7S0
SMRiQ8P7S0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F6H Bacteria
COG0159 LUCA
HOGENOMiHOG000223815
KOiK01695
OMAiDYPPEEC

Family and domain databases

CDDicd04724 Tryptophan_synthase_alpha, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00131 Trp_synth_alpha, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR011060 RibuloseP-bd_barrel
IPR018204 Trp_synthase_alpha_AS
IPR002028 Trp_synthase_suA
PfamiView protein in Pfam
PF00290 Trp_syntA, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR00262 trpA, 1 hit
PROSITEiView protein in PROSITE
PS00167 TRP_SYNTHASE_ALPHA, 1 hit

Sequencei

Sequence statusi: Complete.

Q8P7S0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRAPDRIAA CFDALRHSGR KALIPFITAG DPSLEATVPV MHALVRAGAN
60 70 80 90 100
IIELGVPFSD PMADGPTIQR SSERALGRGA GLAYVIEAVQ EFRREDATTP
110 120 130 140 150
VVLMGYLNPI EIHGTRRFAE TAVAAGIDGV LLVDLPPEEA DETRAIFTEV
160 170 180 190 200
GLALIALASP TTGEARLDML CSTAQGYLYY VSFSGVTGAA DRLDTHAASD
210 220 230 240 250
RLRQLRARAG APVVAGFGIK DAASAAAMAV DADGVVVGSA LVAALADASD
260 270
VRSARKRAED FLQPLRQALD AG
Length:272
Mass (Da):28,396
Last modified:October 1, 2002 - v1
Checksum:i87F6C11E51806806
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008922 Genomic DNA Translation: AAM41813.1
RefSeqiNP_637889.1, NC_003902.1
WP_011037671.1, NC_003902.1

Genome annotation databases

EnsemblBacteriaiAAM41813; AAM41813; XCC2541
GeneIDi999016
KEGGixcc:XCC2541
PATRICifig|190485.4.peg.2707

Similar proteinsi

Entry informationi

Entry nameiTRPA_XANCP
AccessioniPrimary (citable) accession number: Q8P7S0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: October 1, 2002
Last modified: February 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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