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Q8P7J1

- SYL_XANCP

UniProt

Q8P7J1 - SYL_XANCP

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei641 – 6411ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciXCAM190485:GIXZ-2618-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:XCC2620
OrganismiXanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
Taxonomic identifieri190485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000001010: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 816816Leucine--tRNA ligasePRO_0000152121Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi190485.XCC2620.

Structurei

3D structure databases

ProteinModelPortaliQ8P7J1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi46 – 5611"HIGH" regionAdd
BLAST
Motifi638 – 6425"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8P7J1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTVEPNAYD PQQVETSAQQ FWDATRAFQV DENSDKPKFY CLSMLPYPSG
60 70 80 90 100
ALHMGHVRNY TISDVVSRYK RMTGHNVLQP MGWDAFGLPA ENAAIKNKTA
110 120 130 140 150
PAKWTYANIE HMRAQLKSLG YAIDWSREFA TCTPDYYVHE QRMFTRLMRK
160 170 180 190 200
GLAYRRNAVV NWDPIDQTVL ANEQVIDGRG WRSGALVEKR EIPQWFLRIT
210 220 230 240 250
DYAQELLDGL DQLDGWPDSV KTMQRNWIGR SEGLEIQFDV RDTTGAALDP
260 270 280 290 300
LRVFTTRPDT LMGVTFVSIA AEHPLAQHAA KSNPELASML ETLKHGGVSE
310 320 330 340 350
AELETQEKRG MATGLTAVHP ISGEEVPVWV ANFVLMGYGT GAVMAVPGHD
360 370 380 390 400
QRDFEFANKY GLPIVQVVKL REPRNDDEQA WDATQWRDWY TDKSRELELI
410 420 430 440 450
NSAEFDGLDY HGAFEALAER FERKGQGQRR INYRLRDWGV SRQRYWGCPI
460 470 480 490 500
PVIYCAKCGA VPVPEDQLPV VLPENVEFAG TGSPIKTDPT WRQTTCPECG
510 520 530 540 550
GPAERETDTF DTFMESSWYV ARYTSPNARD MVDRRANYWM PADLYVGGIE
560 570 580 590 600
HAILHLMYFR FYHKLMRDAR LVDSDEPVTN LLTQGMVIAE TFYRDADNGG
610 620 630 640 650
KDWINPADVE IQRDERGRVV GASLIADGQP VHIGGTEKMS KSKNNGVDPQ
660 670 680 690 700
AMVAKYGADT VRLFSMFAAP PEQSLEWNEA GVDGMARFMR RLWVQVHKHV
710 720 730 740 750
GEGAAALDVA SLSAEQKAIR RKTHETIGKV DDDYGRRHSF NTAIAAVMEL
760 770 780 790 800
SNALAKFDDA SAQGRAVRQE ALEAMVLLLN PITPHASHAL WQVLGRGETL
810
LENVPFPQVD AAGAGA
Length:816
Mass (Da):91,730
Last modified:June 7, 2004 - v2
Checksum:iB9D83BBF55F607BC
GO

Sequence cautioni

The sequence AAM41892.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008922 Genomic DNA. Translation: AAM41892.1. Different initiation.
RefSeqiNP_637968.2. NC_003902.1.

Genome annotation databases

EnsemblBacteriaiAAM41892; AAM41892; XCC2620.
GeneIDi999058.
KEGGixcc:XCC2620.
PATRICi24076198. VBIXanCam115730_2789.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008922 Genomic DNA. Translation: AAM41892.1 . Different initiation.
RefSeqi NP_637968.2. NC_003902.1.

3D structure databases

ProteinModelPortali Q8P7J1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 190485.XCC2620.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM41892 ; AAM41892 ; XCC2620 .
GeneIDi 999058.
KEGGi xcc:XCC2620.
PATRICi 24076198. VBIXanCam115730_2789.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci XCAM190485:GIXZ-2618-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiSYL_XANCP
AccessioniPrimary (citable) accession number: Q8P7J1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: October 29, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3