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Q8P5D7 (BETA_XANCP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Oxygen-dependent choline dehydrogenase

Short name=CDH
Short name=CHD
EC=1.1.99.1
Alternative name(s):
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betA
Ordered Locus Names:XCC3404
OrganismXanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568) [Reference proteome] [HAMAP]
Taxonomic identifier190485 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

Protein attributes

Sequence length556 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity. HAMAP-Rule MF_00750

Catalytic activity

Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP-Rule MF_00750

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00750

Cofactor

FAD By similarity. HAMAP-Rule MF_00750

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP-Rule MF_00750

Sequence similarities

Belongs to the GMC oxidoreductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 556556Oxygen-dependent choline dehydrogenase HAMAP-Rule MF_00750
PRO_0000205609

Regions

Nucleotide binding6 – 3530FAD By similarity

Sites

Active site4751 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8P5D7 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 12409448073F6478

FASTA55661,445
        10         20         30         40         50         60 
MQREYDYIII GAGSAGNVLA ARLTEDPGVS VLLLEAGGPD YRLDFRTQMP AALAFPLQGR 

        70         80         90        100        110        120 
RYNWAYETEP EPHMDNRRME CGRGKGLGGS SLINGMCYIR GNALDFDHWA KRPGLEDWGY 

       130        140        150        160        170        180 
RDVLPYFRKA ETRDIGANDY HGGEGPVSVA TPKNDNNVLF QAMVDAGVQA GYPRTDDLNG 

       190        200        210        220        230        240 
YQQEGFGPMD RTVTPQGRRA STARGYLDMA KPRDSLHIVT HATTDRILFA GKRAVGVHYL 

       250        260        270        280        290        300 
VGNSSEGIDA HARREVLVCA GAIASPQLLQ RSGVGAPDLL RALDVQLVHD LPGVGQNLQD 

       310        320        330        340        350        360 
HLEVYMQYAC TKPVSLYPAL QWWNQPAIGA EWLFAGTGTG ASNQFEAGGF IRTREEFDWP 

       370        380        390        400        410        420 
NIQYHFLPVA INYNGSNAVK EHGFQAHVGS MRTPSRGRVH ARSRDPRQHP SILFNYQSTD 

       430        440        450        460        470        480 
QDWQEFRDAI RITREIIAQP ALDPYRGREI SPSADCKTDA ELDAFVRARA ETAYHPSCSC 

       490        500        510        520        530        540 
AMGTDDMAVV DGQGRVHGME GLRVIDASIM PRIITGNLNA TTIMIAEKIV DRIRGRAPLP 

       550 
RSTADYYVAG DAPVRR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008922 Genomic DNA. Translation: AAM42674.1.
RefSeqNP_638750.1. NC_003902.1.

3D structure databases

ProteinModelPortalQ8P5D7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING190485.XCC3404.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM42674; AAM42674; XCC3404.
GeneID999936.
KEGGxcc:XCC3404.
PATRIC24077910. VBIXanCam115730_3641.

Phylogenomic databases

eggNOGCOG2303.
HOGENOMHOG000139600.
KOK00108.
OMAYLQYACT.
OrthoDBEOG67HJQP.

Enzyme and pathway databases

BioCycXCAM190485:GIXZ-3402-MONOMER.
UniPathwayUPA00529; UER00385.

Family and domain databases

HAMAPMF_00750. Choline_dehydrogen.
InterProIPR011533. Choline_dehydrogenase.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsTIGR01810. betA. 1 hit.
PROSITEPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETA_XANCP
AccessionPrimary (citable) accession number: Q8P5D7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: October 1, 2002
Last modified: May 14, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways