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Q8P5D7

- BETA_XANCP

UniProt

Q8P5D7 - BETA_XANCP

Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

    Catalytic activityi

    Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei475 – 4751UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi6 – 3530FADUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
    2. choline dehydrogenase activity Source: UniProtKB-HAMAP
    3. flavin adenine dinucleotide binding Source: InterPro

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NAD

    Enzyme and pathway databases

    BioCyciXCAM190485:GIXZ-3402-MONOMER.
    UniPathwayiUPA00529; UER00385.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
    Short name:
    CDHUniRule annotation
    Short name:
    CHDUniRule annotation
    Alternative name(s):
    Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betAUniRule annotation
    Ordered Locus Names:XCC3404
    OrganismiXanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
    Taxonomic identifieri190485 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
    ProteomesiUP000001010: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Oxygen-dependent choline dehydrogenasePRO_0000205609Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi190485.XCC3404.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8P5D7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GMC oxidoreductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2303.
    HOGENOMiHOG000139600.
    KOiK00108.
    OMAiYLQYACT.
    OrthoDBiEOG67HJQP.

    Family and domain databases

    HAMAPiMF_00750. Choline_dehydrogen.
    InterProiIPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view]
    PfamiPF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsiTIGR01810. betA. 1 hit.
    PROSITEiPS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8P5D7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQREYDYIII GAGSAGNVLA ARLTEDPGVS VLLLEAGGPD YRLDFRTQMP    50
    AALAFPLQGR RYNWAYETEP EPHMDNRRME CGRGKGLGGS SLINGMCYIR 100
    GNALDFDHWA KRPGLEDWGY RDVLPYFRKA ETRDIGANDY HGGEGPVSVA 150
    TPKNDNNVLF QAMVDAGVQA GYPRTDDLNG YQQEGFGPMD RTVTPQGRRA 200
    STARGYLDMA KPRDSLHIVT HATTDRILFA GKRAVGVHYL VGNSSEGIDA 250
    HARREVLVCA GAIASPQLLQ RSGVGAPDLL RALDVQLVHD LPGVGQNLQD 300
    HLEVYMQYAC TKPVSLYPAL QWWNQPAIGA EWLFAGTGTG ASNQFEAGGF 350
    IRTREEFDWP NIQYHFLPVA INYNGSNAVK EHGFQAHVGS MRTPSRGRVH 400
    ARSRDPRQHP SILFNYQSTD QDWQEFRDAI RITREIIAQP ALDPYRGREI 450
    SPSADCKTDA ELDAFVRARA ETAYHPSCSC AMGTDDMAVV DGQGRVHGME 500
    GLRVIDASIM PRIITGNLNA TTIMIAEKIV DRIRGRAPLP RSTADYYVAG 550
    DAPVRR 556
    Length:556
    Mass (Da):61,445
    Last modified:October 1, 2002 - v1
    Checksum:i12409448073F6478
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008922 Genomic DNA. Translation: AAM42674.1.
    RefSeqiNP_638750.1. NC_003902.1.

    Genome annotation databases

    EnsemblBacteriaiAAM42674; AAM42674; XCC3404.
    GeneIDi999936.
    KEGGixcc:XCC3404.
    PATRICi24077910. VBIXanCam115730_3641.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008922 Genomic DNA. Translation: AAM42674.1 .
    RefSeqi NP_638750.1. NC_003902.1.

    3D structure databases

    ProteinModelPortali Q8P5D7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 190485.XCC3404.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM42674 ; AAM42674 ; XCC3404 .
    GeneIDi 999936.
    KEGGi xcc:XCC3404.
    PATRICi 24077910. VBIXanCam115730_3641.

    Phylogenomic databases

    eggNOGi COG2303.
    HOGENOMi HOG000139600.
    KOi K00108.
    OMAi YLQYACT.
    OrthoDBi EOG67HJQP.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00385 .
    BioCyci XCAM190485:GIXZ-3402-MONOMER.

    Family and domain databases

    HAMAPi MF_00750. Choline_dehydrogen.
    InterProi IPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view ]
    Pfami PF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsi TIGR01810. betA. 1 hit.
    PROSITEi PS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiBETA_XANCP
    AccessioniPrimary (citable) accession number: Q8P5D7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 16, 2004
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3