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Protein

Periplasmic trehalase

Gene

treA

Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system.UniRule annotation

Catalytic activityi

Alpha,alpha-trehalose + H2O = beta-D-glucose + alpha-D-glucose.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei169 – 1691SubstrateUniRule annotation
Binding sitei213 – 2131SubstrateUniRule annotation
Binding sitei327 – 3271Substrate; via carbonyl oxygenUniRule annotation
Active sitei329 – 3291Proton donor/acceptorUniRule annotation
Active sitei511 – 5111Proton donor/acceptorUniRule annotation
Binding sitei526 – 5261SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciXCAM190485:GIXZ-3527-MONOMER.

Protein family/group databases

CAZyiGH37. Glycoside Hydrolase Family 37.

Names & Taxonomyi

Protein namesi
Recommended name:
Periplasmic trehalaseUniRule annotation (EC:3.2.1.28UniRule annotation)
Alternative name(s):
Alpha,alpha-trehalaseUniRule annotation
Alpha,alpha-trehalose glucohydrolaseUniRule annotation
Gene namesi
Name:treAUniRule annotation
Ordered Locus Names:XCC3529
OrganismiXanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Taxonomic identifieri190485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000001010 Componenti: Chromosome

Subcellular locationi

  • Periplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3838UniRule annotationAdd
BLAST
Chaini39 – 568530Periplasmic trehalasePRO_0000012050Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi190485.XCC3529.

Structurei

3D structure databases

ProteinModelPortaliQ8P519.
SMRiQ8P519. Positions 54-550.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni176 – 1772Substrate bindingUniRule annotation
Regioni222 – 2243Substrate bindingUniRule annotation
Regioni294 – 2963Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the glycosyl hydrolase 37 family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105E53. Bacteria.
COG1626. LUCA.
HOGENOMiHOG000215464.
KOiK01194.
OMAiWAGQLHQ.

Family and domain databases

HAMAPiMF_01060. Peripl_trehalase. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR001661. Glyco_hydro_37.
IPR018232. Glyco_hydro_37_CS.
IPR023720. Trehalase_periplasmic.
[Graphical view]
PANTHERiPTHR23403. PTHR23403. 1 hit.
PfamiPF01204. Trehalase. 1 hit.
[Graphical view]
PRINTSiPR00744. GLHYDRLASE37.
SUPFAMiSSF48208. SSF48208. 1 hit.
PROSITEiPS00927. TREHALASE_1. 1 hit.
PS00928. TREHALASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8P519-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHAPARSGD AMSAAAPPCC TSLLGLSLSM FVAPCALAAT PLEGAVVSAP
60 70 80 90 100
APTPPTPDLA YPELFQAVQR GELFDDQKHF VDFLPLRDPA LINADYLAQH
110 120 130 140 150
EHAGFDLRKF VDANFEESPP VQTDAIRQDT ALREHIDALW PKLVRSQTNV
160 170 180 190 200
PAHSSLLALP HPYVVPGGRF REVYYWDSYF TMLGLVKSGE TTLSRQMLDN
210 220 230 240 250
FAYLIDTYGH IPNGNRTYYL SRSQPPLFSY MVELQAGVEG EAVYQRYLPQ
260 270 280 290 300
LQKEYAYWMQ GGDDLQPGQA ARHVVRLADG SVLNRYWDER DTPRPEAWLH
310 320 330 340 350
DTRTAAEAHD RPAADVYRDL RAGAESGWDY TSRWLADGKT LSTIRTTAIV
360 370 380 390 400
PIDLNSLLYH LERTLAQACA HTGTACSQDY AALAQQRKQA IDAHLWNAAG
410 420 430 440 450
YYADYDWQTR TLSNQVTAAA LYPLFAGLAS DDHAKRTATS VRARLLRPGG
460 470 480 490 500
LATTALKTGQ QWDEPNGWAP LQWVAVDGLR RYGEDGLART IGERFLTQVQ
510 520 530 540 550
ALFAREHKLV EKYGLDADAA GGGGGEYALQ DGFGWTNGVT LMLLNLYPSQ
560
GATQAPAKTK RKPEPAAP
Length:568
Mass (Da):62,692
Last modified:October 1, 2002 - v1
Checksum:iBF6A36276D3D7B5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008922 Genomic DNA. Translation: AAM42799.1.
RefSeqiNP_638875.2. NC_003902.1.

Genome annotation databases

EnsemblBacteriaiAAM42799; AAM42799; XCC3529.
GeneIDi1000094.
KEGGixcc:XCC3529.
PATRICi24078182. VBIXanCam115730_3777.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008922 Genomic DNA. Translation: AAM42799.1.
RefSeqiNP_638875.2. NC_003902.1.

3D structure databases

ProteinModelPortaliQ8P519.
SMRiQ8P519. Positions 54-550.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190485.XCC3529.

Protein family/group databases

CAZyiGH37. Glycoside Hydrolase Family 37.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM42799; AAM42799; XCC3529.
GeneIDi1000094.
KEGGixcc:XCC3529.
PATRICi24078182. VBIXanCam115730_3777.

Phylogenomic databases

eggNOGiENOG4105E53. Bacteria.
COG1626. LUCA.
HOGENOMiHOG000215464.
KOiK01194.
OMAiWAGQLHQ.

Enzyme and pathway databases

BioCyciXCAM190485:GIXZ-3527-MONOMER.

Family and domain databases

HAMAPiMF_01060. Peripl_trehalase. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR001661. Glyco_hydro_37.
IPR018232. Glyco_hydro_37_CS.
IPR023720. Trehalase_periplasmic.
[Graphical view]
PANTHERiPTHR23403. PTHR23403. 1 hit.
PfamiPF01204. Trehalase. 1 hit.
[Graphical view]
PRINTSiPR00744. GLHYDRLASE37.
SUPFAMiSSF48208. SSF48208. 1 hit.
PROSITEiPS00927. TREHALASE_1. 1 hit.
PS00928. TREHALASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTREA_XANCP
AccessioniPrimary (citable) accession number: Q8P519
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.