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Q8P3Z4 (SYW_XANCP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:XCC3923
OrganismXanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568) [Reference proteome] [HAMAP]
Taxonomic identifier190485 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 431431Tryptophan--tRNA ligase HAMAP-Rule MF_00140
PRO_0000136713

Regions

Motif13 – 219"HIGH" region HAMAP-Rule MF_00140
Motif204 – 2085"KMSKS" region HAMAP-Rule MF_00140

Sites

Binding site2071ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8P3Z4 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 1043117CB2239037

FASTA43147,101
        10         20         30         40         50         60 
MQMTTRVLTG ITPSGTPHLG NYVGAIRPAI QASTATDAES FYFLADLHSL IKAQDPARTQ 

        70         80         90        100        110        120 
RSTLEIAASW LACGLDPDKV WFYRQSDVPE TTELMWLLTC VAGKGILNRA HAYKAAMDKN 

       130        140        150        160        170        180 
RAEGEDEDAG VTAGLFMYPV LMAADILIFN AHKVPVGRDQ IQHIEMARDF AQRFNHVYGQ 

       190        200        210        220        230        240 
DYFTLPDAVI DEQVATLPGL DGRKMSKSYN NTIPLFAPRE ELRKLVFSIL TDSRAPGEAK 

       250        260        270        280        290        300 
DTQGSALFQL YQAFATPQET AAFAQAFADG ISWADAKQQL FERIDLEIAP LRARYEALMA 

       310        320        330        340        350        360 
EPAKIEATLR AGGARLRARY ATPLLAQLRD AVGLRDLSSQ ASAVGPATAV KAALPVFKQY 

       370        380        390        400        410        420 
RESDGQFYFK LHDAAGTLLL QSDGFASPRE AGQLIARLKQ AEDTTQLQLP GVQLPADAAP 

       430 
VLAALRALRE A 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008922 Genomic DNA. Translation: AAM43145.1.
RefSeqNP_639263.1. NC_003902.1.

3D structure databases

ProteinModelPortalQ8P3Z4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING190485.XCC3923.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM43145; AAM43145; XCC3923.
GeneID1000585.
KEGGxcc:XCC3923.
PATRIC24079041. VBIXanCam115730_4198.

Phylogenomic databases

eggNOGCOG0180.
HOGENOMHOG000059939.
KOK01867.
OMAHIEMARA.
OrthoDBEOG686NJQ.

Enzyme and pathway databases

BioCycXCAM190485:GIXZ-3921-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_B. Trp_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYW_XANCP
AccessionPrimary (citable) accession number: Q8P3Z4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries