Q8P3H1 (XYLA2_XANCP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Xylose isomerase 2
EC=5.3.1.5

Gene names

Name:	xylA2
Ordered Locus Names:	XCC4100

Organism

Xanthomonas campestris pv. campestris

Taxonomic identifier

340 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas

Protein attributes

Sequence length	446 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-xylose = D-xylulose. HAMAP MF_00455
Cofactor	Binds 2 magnesium ions per subunit By similarity. HAMAP MF_00455
Subunit structure	Homotetramer By similarity. HAMAP MF_00455
Subcellular location	Cytoplasm By similarity HAMAP MF_00455.
Sequence similarities	Belongs to the xylose isomerase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Pentose shunt Xylose metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	D-xylose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW xylose isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 446	446	Xylose isomerase 2 HAMAP MF_00455		PRO_0000195822
Sites
	Active site	109	1	By similarity
	Active site	112	1	By similarity
	Metal binding	240	1	Magnesium 1 By similarity
	Metal binding	276	1	Magnesium 1 By similarity
	Metal binding	276	1	Magnesium 2 By similarity
	Metal binding	279	1	Magnesium 2 By similarity
	Metal binding	304	1	Magnesium 1 By similarity
	Metal binding	315	1	Magnesium 2 By similarity
	Metal binding	317	1	Magnesium 2 By similarity
	Metal binding	347	1	Magnesium 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8P3H1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 515F13FDF24B6C67	FASTA	446	48,792
	10 20 30 40 50 60 MSNTVFIGAK EYFPGIGKIG FEGRDSDNPL AFKVYDANKQ VAGKTMAEHL RFAVAYWHSF 70 80 90 100 110 120 CGNGADPFGP GTRAYPWDVG NTALARAEAK SDAAFEFFTK LGVPYYCFHD IDLAPDADDI 130 140 150 160 170 180 GEYENNLKHM VGIAKQRQAD TGVKLLWGTA NLFSHPRYMN GASTNPDFNV VARAAVQVKA 190 200 210 220 230 240 AIDATVELGG ENYVFWGGRE GYACLHNTQM KREQDNMARF LTLARDYGRA IGFKGNFLIE 250 260 270 280 290 300 PKPMEPMKHQ YDFDSATVIG FLRQHGLDQD FKLNIEANHA TLSGHSFEHD LQVASDAGLL 310 320 330 340 350 360 GSIDANRGNP QNGWDTDQFP TDLYDTVGAM LVVLRQGGLA PGGLNFDAKV RRESSDPQDL 370 380 390 400 410 420 FLAHIGGMDA FARGLEVADA LLTSSPLETW RAQRYASFDS GAGADFANGT STLADLATYA 430 440 AGKGEPTQLS GRQEAYENLI NQYLTR

References

[1]

"Comparison of the genomes of two Xanthomonas pathogens with differing host specificities." da Silva A.C.R., Ferro J.A., Reinach F.C., Farah C.S., Furlan L.R., Quaggio R.B., Monteiro-Vitorello C.B., Van Sluys M.A., Almeida N.F. Jr., Alves L.M.C., do Amaral A.M., Bertolini M.C., Camargo L.E.A., Camarotte G., Cannavan F., Cardozo J., Chambergo F., Ciapina L.P. , Cicarelli R.M.B., Coutinho L.L., Cursino-Santos J.R., El-Dorry H., Faria J.B., Ferreira A.J.S., Ferreira R.C.C., Ferro M.I.T., Formighieri E.F., Franco M.C., Greggio C.C., Gruber A., Katsuyama A.M., Kishi L.T., Leite R.P., Lemos E.G.M., Lemos M.V.F., Locali E.C., Machado M.A., Madeira A.M.B.N., Martinez-Rossi N.M., Martins E.C., Meidanis J., Menck C.F.M., Miyaki C.Y., Moon D.H., Moreira L.M., Novo M.T.M., Okura V.K., Oliveira M.C., Oliveira V.R., Pereira H.A., Rossi A., Sena J.A.D., Silva C., de Souza R.F., Spinola L.A.F., Takita M.A., Tamura R.E., Teixeira E.C., Tezza R.I.D., Trindade dos Santos M., Truffi D., Tsai S.M., White F.F., Setubal J.C., Kitajima J.P. Nature 417:459-463(2002) [PubMed: 12024217] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33913 / NCPPB 528 / LMG 568.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008922 Genomic DNA. Translation: AAM43321.1.
RefSeq	NP_639439.1. NC_003902.1.
3D structure databases
ProteinModelPortal	Q8P3H1.
SMR	Q8P3H1. Positions 10-446.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1000898.
GenomeReviews	Gene locus XCC4100 in contig AE008922_GR.
KEGG	xcc:XCC4100.
PATRIC	24079436. VBIXanCam115730_4394.
Phylogenomic databases
HOGENOM	HBG297199.
OMA	LLGWDTD.
ProtClustDB	PRK12465.
Enzyme and pathway databases
BioCyc	XCAM190485:XCC4100-MONOMER.
Family and domain databases
HAMAP	MF_00455. Xylose_isom_A. [Tree]
InterPro	IPR013022. Xyl_isomerase-like_TIM-brl. IPR012307. Xyl_isomerase_TIM-brl. IPR013452. Xylose_isom_bac. IPR001998. Xylose_isomerase. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KO	K01805.
Pfam	PF01261. AP_endonuc_2. 1 hit. [Graphical view]
PRINTS	PR00688. XYLOSISMRASE.
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR02630. Xylose_isom_A. 1 hit.
PROSITE	PS51415. XYLOSE_ISOMERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XYLA2_XANCP

Accession

Primary (citable) accession number: Q8P3H1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program