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Protein

Glycerol-3-phosphate acyltransferase

Gene

plsB

Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase (plsB)
  2. no protein annotated in this organism
  3. Phosphatidate cytidylyltransferase (cdsA)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00557; UER00612.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate acyltransferase (EC:2.3.1.15)
Short name:
GPAT
Gene namesi
Name:plsB
Ordered Locus Names:XCC4128
OrganismiXanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Taxonomic identifieri190485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000001010 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001952401 – 886Glycerol-3-phosphate acyltransferaseAdd BLAST886

Interactioni

Protein-protein interaction databases

STRINGi190485.XCC4128.

Structurei

3D structure databases

ProteinModelPortaliQ8P3E3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi362 – 367HXXXXD motif6

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.By similarity

Sequence similaritiesi

Belongs to the GPAT/DAPAT family.Curated

Phylogenomic databases

eggNOGiENOG4105E55. Bacteria.
COG2937. LUCA.
HOGENOMiHOG000218231.
KOiK00631.
OMAiEVIYVPC.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans. 1 hit.
InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 2 hits.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03703. plsB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8P3E3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEQNPLPFP DGQSAPPSPA GAETGATAAA LPPAAPVALD APAPAAPVLA
60 70 80 90 100
PARVAKRPWW ARLLGRLADP WLSLTIEPEQ PGRYDDGKPV VYVLEDYGLS
110 120 130 140 150
NALILDKACR EAGLPSPLVP LPGDPLERKR AYLALSRRSS SNSLIPEQRG
160 170 180 190 200
GKTHSDSLAK LLQAHRVRAD LDVHLVPVSI FVGRAPDKQS GWFAVLFSEN
210 220 230 240 250
WALVGRFRRL LSVLLNGRTT IVRFAPPISL RQTMAEGLPP ERTLRKLQRV
260 270 280 290 300
LRTHFRRIRE AVIGPDLSTR RLLVDQVLAA DSVREAIATQ AKRDNSKPVD
310 320 330 340 350
AWRKAHAYAW EIAADYSSPV VRSASFLLTH VWNRIYAGVL VHHLDKLKQA
360 370 380 390 400
APGHEVVYVP SHRSHMDYLL LSYLLYERGI VPPHIVAGIN LNLPVVGTLL
410 420 430 440 450
RKGGAFFIRR SIRGNALYSA VLSEYVAQLV AGGYSIEYFV EGGRSRTGRL
460 470 480 490 500
LQPKGGMIAM TLRAYLRQPR KPVLFQPVYI GYEKLMEGNS YLDELTGRPK
510 520 530 540 550
EKESIWGLLW SIPKVLKQNY GQVVVNFGEP IALNDVLAKH APEWNGEPLP
560 570 580 590 600
DDEKPTWLAP AVDTLATQIQ TRINCAADVN PINLLALALL STPKHAMGEA
610 620 630 640 650
DLIAQIELCK KLLAEMPYSD RVTVTPHTPA RIITHAEEIN VLTRVSHPLG
660 670 680 690 700
DVLSVSGDTA VLLSYFRNNV LHLFTASSWV ACCFQNNRRM SRAGLLRLGR
710 720 730 740 750
TVYPFLQAEL FLPWSEDRFA ERIEQTIDMF VREGLLLNVT DDDGGILARN
760 770 780 790 800
TGQTDEVFRL RAIGHSLQQA FERYYIAISV LVKNGPGVLG AGELESLCQQ
810 820 830 840 850
AAQRLSLLYA PAAPEFFDKT LFRSFIQKLR ELRLVWPDEN SKLMFDERLD
860 870 880
AWAKDAKFIL GRELRHTIER VSPEAAKPDV VSPPAE
Length:886
Mass (Da):98,460
Last modified:October 10, 2002 - v1
Checksum:iA91787C8CCB5341F
GO

Sequence cautioni

The sequence AAM43349 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008922 Genomic DNA. Translation: AAM43349.1. Different initiation.
RefSeqiNP_639467.1. NC_003902.1.

Genome annotation databases

EnsemblBacteriaiAAM43349; AAM43349; XCC4128.
GeneIDi1001103.
KEGGixcc:XCC4128.
PATRICi24079492. VBIXanCam115730_4422.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008922 Genomic DNA. Translation: AAM43349.1. Different initiation.
RefSeqiNP_639467.1. NC_003902.1.

3D structure databases

ProteinModelPortaliQ8P3E3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190485.XCC4128.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM43349; AAM43349; XCC4128.
GeneIDi1001103.
KEGGixcc:XCC4128.
PATRICi24079492. VBIXanCam115730_4422.

Phylogenomic databases

eggNOGiENOG4105E55. Bacteria.
COG2937. LUCA.
HOGENOMiHOG000218231.
KOiK00631.
OMAiEVIYVPC.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00612.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans. 1 hit.
InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 2 hits.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03703. plsB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLSB_XANCP
AccessioniPrimary (citable) accession number: Q8P3E3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.