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Q8P3D7 (PYRF_XANCP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
Ordered Locus Names:XCC4134
OrganismXanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568) [Reference proteome] [HAMAP]
Taxonomic identifier190485 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

Protein attributes

Sequence length243 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity. HAMAP-Rule MF_01200

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2. HAMAP-Rule MF_01200

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. HAMAP-Rule MF_01200

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01200

Sequence similarities

Belongs to the OMP decarboxylase family. Type 1 subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 243243Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01200
PRO_0000134603

Regions

Region69 – 7810Substrate binding By similarity

Sites

Active site711Proton donor By similarity
Binding site191Substrate By similarity
Binding site411Substrate By similarity
Binding site1241Substrate By similarity
Binding site1851Substrate By similarity
Binding site1941Substrate By similarity
Binding site2141Substrate; via amide nitrogen By similarity
Binding site2151Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8P3D7 [UniParc].

Last modified October 10, 2002. Version 1.
Checksum: AC24F2E0D839BB64

FASTA24325,688
        10         20         30         40         50         60 
MNRPPLPLAA HDRLIFALDV PGHDEAIAWV DRLGESVAFY KIGMELLASG EYFHVLDALA 

        70         80         90        100        110        120 
KRNKRVFVDL KFFDIPATVA GTIRRLSQWP VSYCTVHGWH AGMLEAAAAA NQGDMRLLAV 

       130        140        150        160        170        180 
TVLTSMGRPD LAAMGIDREP VDVVVERALA AQAAGIDGVI ASGQEAGMIR RATGPAFSIV 

       190        200        210        220        230        240 
CPGIRPGGPV GDDQQRTVGV AQAFADGADA IVVGRPIRLA NDPAAAAAAI QAEIRAAVVQ 


HRD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008922 Genomic DNA. Translation: AAM43355.1.
RefSeqNP_639473.1. NC_003902.1.

3D structure databases

ProteinModelPortalQ8P3D7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING190485.XCC4134.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM43355; AAM43355; XCC4134.
GeneID1001145.
KEGGxcc:XCC4134.
PATRIC24079506. VBIXanCam115730_4429.

Phylogenomic databases

eggNOGCOG0284.
HOGENOMHOG000226070.
KOK01591.
OMARPITQSA.
OrthoDBEOG6N6815.

Enzyme and pathway databases

BioCycXCAM190485:GIXZ-4132-MONOMER.
UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01200_B. OMPdecase_type1_B.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_XANCP
AccessionPrimary (citable) accession number: Q8P3D7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: May 14, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways