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Q8P2R3

- G6PI_STRP8

UniProt

Q8P2R3 - G6PI_STRP8

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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Streptococcus pyogenes serotype M18 (strain MGAS8232)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei291 – 2911Proton donorUniRule annotation
Active sitei312 – 3121UniRule annotation
Active sitei426 – 4261UniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciSPYO186103:GHJG-210-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:spyM18_0204
OrganismiStreptococcus pyogenes serotype M18 (strain MGAS8232)
Taxonomic identifieri186103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000820: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Glucose-6-phosphate isomerasePRO_0000180741Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi186103.spyM18_0204.

Structurei

3D structure databases

ProteinModelPortaliQ8P2R3.
SMRiQ8P2R3. Positions 3-449.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000100403.
KOiK01810.
OMAiKNMTHIT.
OrthoDBiEOG64R61J.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8P2R3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHITFDYSK VLESFAGQHE IDFLQGQVTE ADKLLREGTG PGSDFLGWLD
60 70 80 90 100
LPENYDKEEF ARILTAAEKI KSDSEVLVVI GIGGSYLGAK AAIDFLNHHF
110 120 130 140 150
ANLQTAKERK APQILYAGNS ISSTYLADLV EYVQDKEFSV NVISKSGTTT
160 170 180 190 200
EPAIAFRVFK ELLVKKYGQE EANKRIYATT DKVKGAVKVE ADANNWETFV
210 220 230 240 250
VPDNVGGRFS VLTAVGLLPI AASGADITAL MEGANAARKD LSSDKISENI
260 270 280 290 300
AYQYAAVRNV LYRKGYITEI LANYEPSLQY FGEWWKQLAG ESEGKDQKGI
310 320 330 340 350
YPTSANFSTD LHSLGQFIQE GYRNLFETVI RVDNPRKNVI IPELAEDLDG
360 370 380 390 400
LGYLQGKDVD FVNKKATDGV LLAHTDGGVP NMFVTLPVQD EFTLGYTIYF
410 420 430 440
FELAIAVSGY MNAVNPFDQP GVEAYKRNMF ALLGKPGFEA LSAELNARL
Length:449
Mass (Da):49,511
Last modified:October 10, 2002 - v1
Checksum:i88231F609502795C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009949 Genomic DNA. Translation: AAL96997.1.
RefSeqiNP_606498.1. NC_003485.1.

Genome annotation databases

EnsemblBacteriaiAAL96997; AAL96997; spyM18_0204.
GeneIDi993644.
KEGGispm:spyM18_0204.
PATRICi19747154. VBIStrPyo4396_0176.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009949 Genomic DNA. Translation: AAL96997.1 .
RefSeqi NP_606498.1. NC_003485.1.

3D structure databases

ProteinModelPortali Q8P2R3.
SMRi Q8P2R3. Positions 3-449.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 186103.spyM18_0204.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL96997 ; AAL96997 ; spyM18_0204 .
GeneIDi 993644.
KEGGi spm:spyM18_0204.
PATRICi 19747154. VBIStrPyo4396_0176.

Phylogenomic databases

eggNOGi COG0166.
HOGENOMi HOG000100403.
KOi K01810.
OMAi KNMTHIT.
OrthoDBi EOG64R61J.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .
BioCyci SPYO186103:GHJG-210-MONOMER.

Family and domain databases

HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks."
    Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S., Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D., Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A., Veasy L.G., Musser J.M.
    Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MGAS8232.

Entry informationi

Entry nameiG6PI_STRP8
AccessioniPrimary (citable) accession number: Q8P2R3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3