Q8P2A6 (RSMI_STRP8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribosomal RNA small subunit methyltransferase I
EC=2.1.1.198

Alternative name(s):
16S rRNA 2'-O-ribose C1402 methyltransferase
rRNA (cytidine-2'-O-)-methyltransferase RsmI

Gene names

Name:	rsmI
Ordered Locus Names:	spyM18_0456

Organism

Streptococcus pyogenes serotype M18 [Complete proteome] [HAMAP]

Taxonomic identifier

301451 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	287 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA By similarity. HAMAP MF_01877
Catalytic activity	S-adenosyl-L-methionine + cytosine(1402) in 16S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytosine(1402) in 16S rRNA. HAMAP MF_01877
Subcellular location	Cytoplasm Potential HAMAP MF_01877.
Sequence similarities	Belongs to the methyltransferase superfamily. RsmI family.

Ontologies

Keywords
Biological process	rRNA processing
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	rRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 287	287	Ribosomal RNA small subunit methyltransferase I HAMAP MF_01877		PRO_0000211957

Sequences

	Sequence		Length	Mass (Da)
	Q8P2A6 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 7C1496D2FD893E51	FASTA	287	31,826
	10 20 30 40 50 60 MQVQKSFKDK KTSGTLYLVP TPIGNLQDMT FRAVATLKEV DFICAEDTRN TGLLLKHFDI 70 80 90 100 110 120 ATKQISFHEH NAYEKIPDLI DLLISGRSLA QVSDAGMPSI SDPGHDLVKA AIDSDIAVVA 130 140 150 160 170 180 LPGASAGITA LIASGLAPQP HVFYGFLSRK AGQQKAFFED KHHYPETQMF YESPYRIKDT 190 200 210 220 230 240 LTNMLACYGD RQVVLVRELT KLFEEYQRGS ISEILSYLEE TSLKGECLLI VAGAQVDSEV 250 260 270 280 ELTADVDLVS LVQKEIQAGA KPNQAIKTIA KAYQVNRQEL YQQFHDL

References

[1]

"Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks." Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S., Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D., Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A., Veasy L.G., Musser J.M. Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002) [PubMed: 11917108] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MGAS8232 / Serotype M18.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009949 Genomic DNA. Translation: AAL97189.1.
RefSeq	NP_606690.1. NC_003485.1.
3D structure databases
ProteinModelPortal	Q8P2A6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000029926; EBSTRP00000028848; EBSTRG00000029926.
GeneID	994378.
GenomeReviews	Gene locus spyM18_0456 in contig AE009949_GR.
KEGG	spm:spyM18_0456.
PATRIC	19747582. VBIStrPyo4396_0384.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000027471.
HOGENOM	HBG529058.
OMA	IASDRFC.
ProtClustDB	CLSK877046.
Enzyme and pathway databases
BioCyc	SPYO186103:SPYM18_0456-MONOMER.
Family and domain databases
HAMAP	MF_01877. 16SrRNA_methyltr_I. [Tree]
InterPro	IPR000878. 4pyrrol_Mease. IPR014777. 4pyrrole_Mease_sub1. IPR008189. rRNA_ssu_MeTfrase_I. IPR018063. SAM_MeTrfase_RsmI_CS. [Graphical view]
Gene3D	G3DSA:3.40.1010.10. 4pyrrole_Mease_sub1. 1 hit.
KO	K07056.
PANTHER	PTHR21091:SF18. PTHR21091:SF18. 1 hit.
Pfam	PF00590. TP_methylase. 1 hit. [Graphical view]
PIRSF	PIRSF005917. MTase_YraL. 1 hit.
SUPFAM	SSF53790. Cor/por_Metransf. 1 hit.
TIGRFAMs	TIGR00096. TIGR00096. 1 hit.
PROSITE	PS01296. RSMI. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RSMI_STRP8

Accession

Primary (citable) accession number: Q8P2A6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program