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Q8P1F1

- PANE_STRP8

UniProt

Q8P1F1 - PANE_STRP8

Protein

Putative 2-dehydropantoate 2-reductase

Gene

apbA

Organism
Streptococcus pyogenes serotype M18 (strain MGAS8232)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.By similarity

    Catalytic activityi

    (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei102 – 1021NADP; via amide nitrogenBy similarity
    Binding sitei102 – 1021SubstrateBy similarity
    Active sitei184 – 1841Proton donorBy similarity
    Binding sitei188 – 1881SubstrateBy similarity
    Binding sitei192 – 1921SubstrateBy similarity
    Binding sitei255 – 2551SubstrateBy similarity
    Binding sitei268 – 2681NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 126NADPBy similarity

    GO - Molecular functioni

    1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciSPYO186103:GHJG-781-MONOMER.
    UniPathwayiUPA00028; UER00004.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
    Alternative name(s):
    Ketopantoate reductase
    Short name:
    KPA reductase
    Short name:
    KPR
    Gene namesi
    Name:apbA
    Ordered Locus Names:spyM18_0911
    OrganismiStreptococcus pyogenes serotype M18 (strain MGAS8232)
    Taxonomic identifieri186103 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000820: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 307307Putative 2-dehydropantoate 2-reductasePRO_0000157321Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi186103.spyM18_0911.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8P1F1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ketopantoate reductase family.Curated

    Phylogenomic databases

    eggNOGiCOG1893.
    HOGENOMiHOG000050222.
    KOiK00077.
    OMAiMGLEPML.
    OrthoDBiEOG6P5ZHG.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8P1F1-1 [UniParc]FASTAAdd to Basket

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    MLVYIAGSGA MGCRFGYQIS KTNNDVILLD NWEDHINAIK ENGLVVTGDV    50
    EETVKLPIMK PTEATQEADL IILFTKAMQL PQMLQDIKGI IGKETKVLCL 100
    LNGLGHEDVI RQYIPEHNIL MGVTVWTAGL EGPGRAHLQG VGALNLQSMD 150
    PNNQDAGHQV ADLLNKANLN ATYDENVVPN IWRKACVNGT MNSTCALLDC 200
    TIGELFASED GLKMVKEIIH EFVIVGQAEG VELNEEEITQ YVMDTSVKAA 250
    HHYPSMHQDL VQNHRLTEID FINGAVNTKG EKLGINTPYC RMITELVHAK 300
    EAVLNIQ 307
    Length:307
    Mass (Da):33,841
    Last modified:October 1, 2002 - v1
    Checksum:iAC4DCD25E5A1CE96
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009949 Genomic DNA. Translation: AAL97561.1.
    RefSeqiNP_607062.1. NC_003485.1.

    Genome annotation databases

    EnsemblBacteriaiAAL97561; AAL97561; spyM18_0911.
    GeneIDi994053.
    KEGGispm:spyM18_0911.
    PATRICi19748427. VBIStrPyo4396_0803.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009949 Genomic DNA. Translation: AAL97561.1 .
    RefSeqi NP_607062.1. NC_003485.1.

    3D structure databases

    ProteinModelPortali Q8P1F1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 186103.spyM18_0911.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL97561 ; AAL97561 ; spyM18_0911 .
    GeneIDi 994053.
    KEGGi spm:spyM18_0911.
    PATRICi 19748427. VBIStrPyo4396_0803.

    Phylogenomic databases

    eggNOGi COG1893.
    HOGENOMi HOG000050222.
    KOi K00077.
    OMAi MGLEPML.
    OrthoDBi EOG6P5ZHG.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00004 .
    BioCyci SPYO186103:GHJG-781-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00745. apbA_panE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks."
      Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S., Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D., Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A., Veasy L.G., Musser J.M.
      Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MGAS8232.

    Entry informationi

    Entry nameiPANE_STRP8
    AccessioniPrimary (citable) accession number: Q8P1F1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3