Reviewed,
UniProtKB/Swiss-Prot Q8P1F1 (PANE_STRP8)
Last modified
February 9, 2010.
Version 50.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Putative 2-dehydropantoate 2-reductase EC=1.1.1.169 Alternative name(s): Ketopantoate reductase Short name=KPA reductase Short name=KPR | ||||
| Gene names |
| ||||
| Organism | Streptococcus pyogenes serotype M18 [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 301451 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus |
Protein attributes
| Sequence length | 307 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid By similarity. |
| Catalytic activity | (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH. |
| Pathway | |
| Subcellular location | Cytoplasm Potential. |
| Sequence similarities | Belongs to the ketopantoate reductase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Pantothenate biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pantothenate biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | 2-dehydropantoate 2-reductase activity Inferred from electronic annotation. Source: EC NADP or NADPH bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 307 | 307 | Putative 2-dehydropantoate 2-reductase | PRO_0000157321 | |||||
Regions | |||||||||
| Nucleotide binding | 7 – 12 | 6 | NADP By similarity | ||||||
Sites | |||||||||
| Active site | 184 | 1 | Proton donor By similarity | ||||||
| Binding site | 102 | 1 | NADP; via amide nitrogen By similarity | ||||||
| Binding site | 102 | 1 | Substrate By similarity | ||||||
| Binding site | 188 | 1 | Substrate By similarity | ||||||
| Binding site | 192 | 1 | Substrate By similarity | ||||||
| Binding site | 255 | 1 | Substrate By similarity | ||||||
| Binding site | 268 | 1 | NADP By similarity | ||||||
Sequences
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References
| [1] | "Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks." Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S., Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D., Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A., Veasy L.G., Musser J.M. Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002) [PubMed: 11917108] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MGAS8232 / Serotype M18. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE009949 Genomic DNA. Translation: AAL97561.1. |
| RefSeq | NP_607062.1. |
3D structure databases | |
| SMR | Q8P1F1. Positions 1-304. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 994053. |
| GenomeReviews | Gene locus spyM18_0911 in contig AE009949_GR. |
| KEGG | spm:spyM18_0911. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG668370. |
| OMA | IDSWQEH. |
Enzyme and pathway databases | |
| BioCyc | SPYO186103:SPYM18_0911-MONOMER. |
Family and domain databases | |
| InterPro | IPR008927. 6-PGluconate_DH_C-like. IPR003710. ApbA. IPR013752. ApbA_C. IPR013332. ApbA_N. IPR013328. DH_multihelical. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit. |
| PANTHER | PTHR21708:SF21. ApbA. 1 hit. |
| Pfam | PF02558. ApbA. 1 hit. PF08546. ApbA_C. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00745. apbA_panE. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | PANE_STRP8 | ||||||||
| Accession | Primary (citable) accession number: Q8P1F1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


