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Q8P151

- HPPK_STRP8

UniProt

Q8P151 - HPPK_STRP8

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Protein
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Gene
folK, spyM18_1062
Organism
Streptococcus pyogenes serotype M18 (strain MGAS8232)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate.

Pathwayi

GO - Molecular functioni

  1. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. folic acid biosynthetic process Source: UniProtKB-KW
  2. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Folate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPYO186103:GHJG-909-MONOMER.
UniPathwayiUPA00077; UER00155.

Names & Taxonomyi

Protein namesi
Recommended name:
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC:2.7.6.3)
Alternative name(s):
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Short name:
PPPK
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Short name:
HPPK
Gene namesi
Name:folK
Ordered Locus Names:spyM18_1062
OrganismiStreptococcus pyogenes serotype M18 (strain MGAS8232)
Taxonomic identifieri186103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000820: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1661662-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PRO_0000168263Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi186103.spyM18_1062.

Structurei

3D structure databases

ProteinModelPortaliQ8P151.

Family & Domainsi

Sequence similaritiesi

Belongs to the HPPK family.

Phylogenomic databases

eggNOGiCOG0801.
HOGENOMiHOG000217741.
KOiK00950.
OMAiFDELSKW.
OrthoDBiEOG6XHC8G.

Family and domain databases

Gene3Di3.30.70.560. 1 hit.
InterProiIPR000550. Hppk.
[Graphical view]
PfamiPF01288. HPPK. 1 hit.
[Graphical view]
SUPFAMiSSF55083. SSF55083. 1 hit.
TIGRFAMsiTIGR01498. folK. 1 hit.
PROSITEiPS00794. HPPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8P151-1 [UniParc]FASTAAdd to Basket

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MTIVYLSLGT NMRDRAAYLQ KALETLADLP QTRLLAQSSI YETAAWGKTD    50
QADFLNMACQ LDTQLTAADF LKETQAIEQS LGRVRHEKWG SRTIDIDILL 100
FGEEVYDTKE LKVPHPYMTE RAFVLIPLLE LQPDLKLPPN HKFLRDYLAA 150
LDQSDITLFS AQQTEF 166
Length:166
Mass (Da):18,981
Last modified:October 1, 2002 - v1
Checksum:i69533C246F402C55
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009949 Genomic DNA. Translation: AAL97686.1.
RefSeqiNP_607187.1. NC_003485.1.

Genome annotation databases

EnsemblBacteriaiAAL97686; AAL97686; spyM18_1062.
GeneIDi995214.
KEGGispm:spyM18_1062.
PATRICi19748709. VBIStrPyo4396_0941.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009949 Genomic DNA. Translation: AAL97686.1 .
RefSeqi NP_607187.1. NC_003485.1.

3D structure databases

ProteinModelPortali Q8P151.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 186103.spyM18_1062.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL97686 ; AAL97686 ; spyM18_1062 .
GeneIDi 995214.
KEGGi spm:spyM18_1062.
PATRICi 19748709. VBIStrPyo4396_0941.

Phylogenomic databases

eggNOGi COG0801.
HOGENOMi HOG000217741.
KOi K00950.
OMAi FDELSKW.
OrthoDBi EOG6XHC8G.

Enzyme and pathway databases

UniPathwayi UPA00077 ; UER00155 .
BioCyci SPYO186103:GHJG-909-MONOMER.

Family and domain databases

Gene3Di 3.30.70.560. 1 hit.
InterProi IPR000550. Hppk.
[Graphical view ]
Pfami PF01288. HPPK. 1 hit.
[Graphical view ]
SUPFAMi SSF55083. SSF55083. 1 hit.
TIGRFAMsi TIGR01498. folK. 1 hit.
PROSITEi PS00794. HPPK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks."
    Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S., Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D., Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A., Veasy L.G., Musser J.M.
    Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MGAS8232.

Entry informationi

Entry nameiHPPK_STRP8
AccessioniPrimary (citable) accession number: Q8P151
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: October 1, 2002
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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