Q8P151 (HPPK_STRP8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EC=2.7.6.3

Alternative name(s):
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Short name=PPPK
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Short name=HPPK

Gene names

Name:	folK
Ordered Locus Names:	spyM18_1062

Organism

Streptococcus pyogenes serotype M18 (strain MGAS8232) [Complete proteome] [HAMAP]

Taxonomic identifier

186103 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus pyogenes › Streptococcus pyogenes serotype M18

Protein attributes

Sequence length	166 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate.
Pathway	Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.
Sequence similarities	Belongs to the HPPK family.

Ontologies

Keywords
Biological process	Folate biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	folic acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity Inferred from electronic annotation. Source: EC ATP binding Inferred from electronic annotation. Source: UniProtKB-KW kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 166	166	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase		PRO_0000168263

Sequences

	Sequence		Length	Mass (Da)
	Q8P151 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 69533C246F402C55	FASTA	166	18,981
	10 20 30 40 50 60 MTIVYLSLGT NMRDRAAYLQ KALETLADLP QTRLLAQSSI YETAAWGKTD QADFLNMACQ 70 80 90 100 110 120 LDTQLTAADF LKETQAIEQS LGRVRHEKWG SRTIDIDILL FGEEVYDTKE LKVPHPYMTE 130 140 150 160 RAFVLIPLLE LQPDLKLPPN HKFLRDYLAA LDQSDITLFS AQQTEF

References

[1]

"Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks." Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S., Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D., Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A., Veasy L.G., Musser J.M. Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MGAS8232.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009949 Genomic DNA. Translation: AAL97686.1.
RefSeq	NP_607187.1. NC_003485.1.
3D structure databases
ProteinModelPortal	Q8P151.
ModBase	Search...
Protein-protein interaction databases
STRING	186103.spyM18_1062.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL97686; AAL97686; spyM18_1062.
GeneID	995214.
KEGG	spm:spyM18_1062.
PATRIC	19748709. VBIStrPyo4396_0941.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0801.
HOGENOM	HOG000217741.
KO	K00950.
OMA	DQDWFLN.
ProtClustDB	CLSK797492.
Enzyme and pathway databases
UniPathway	UPA00077; UER00155.
Family and domain databases
Gene3D	3.30.70.560. 1 hit.
InterPro	IPR000550. Hppk. [Graphical view]
Pfam	PF01288. HPPK. 1 hit. [Graphical view]
SUPFAM	SSF55083. Hppk. 1 hit.
TIGRFAMs	TIGR01498. folK. 1 hit.
PROSITE	PS00794. HPPK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HPPK_STRP8

Accession

Primary (citable) accession number: Q8P151

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2002
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program