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Q8P151 (HPPK_STRP8) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

EC=2.7.6.3
Alternative name(s):
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Short name=PPPK
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Short name=HPPK
Gene names
Name:folK
Ordered Locus Names:spyM18_1062
OrganismStreptococcus pyogenes serotype M18 (strain MGAS8232) [Complete proteome] [HAMAP]
Taxonomic identifier186103 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length166 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.

Sequence similarities

Belongs to the HPPK family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 1661662-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PRO_0000168263

Sequences

Sequence LengthMass (Da)Tools
Q8P151 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 69533C246F402C55

FASTA16618,981
        10         20         30         40         50         60 
MTIVYLSLGT NMRDRAAYLQ KALETLADLP QTRLLAQSSI YETAAWGKTD QADFLNMACQ 

        70         80         90        100        110        120 
LDTQLTAADF LKETQAIEQS LGRVRHEKWG SRTIDIDILL FGEEVYDTKE LKVPHPYMTE 

       130        140        150        160 
RAFVLIPLLE LQPDLKLPPN HKFLRDYLAA LDQSDITLFS AQQTEF 

« Hide

References

[1]"Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks."
Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S., Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D., Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A., Veasy L.G., Musser J.M.
Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MGAS8232.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009949 Genomic DNA. Translation: AAL97686.1.
RefSeqNP_607187.1. NC_003485.1.

3D structure databases

ProteinModelPortalQ8P151.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING186103.spyM18_1062.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL97686; AAL97686; spyM18_1062.
GeneID995214.
KEGGspm:spyM18_1062.
PATRIC19748709. VBIStrPyo4396_0941.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0801.
HOGENOMHOG000217741.
KOK00950.
OMAYNHENIE.
OrthoDBEOG6XHC8G.
ProtClustDBCLSK797492.

Enzyme and pathway databases

BioCycSPYO186103:GHJG-909-MONOMER.
UniPathwayUPA00077; UER00155.

Family and domain databases

Gene3D3.30.70.560. 1 hit.
InterProIPR000550. Hppk.
[Graphical view]
PfamPF01288. HPPK. 1 hit.
[Graphical view]
SUPFAMSSF55083. SSF55083. 1 hit.
TIGRFAMsTIGR01498. folK. 1 hit.
PROSITEPS00794. HPPK. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHPPK_STRP8
AccessionPrimary (citable) accession number: Q8P151
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: October 1, 2002
Last modified: November 13, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways