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Q8P0Z2

- CITX_STRP8

UniProt

Q8P0Z2 - CITX_STRP8

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Protein

Probable apo-citrate lyase phosphoribosyl-dephospho-CoA transferase

Gene

citX

Organism
Streptococcus pyogenes serotype M18 (strain MGAS8232)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Transfers 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A on a serine residue to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield holo-acyl carrier protein.UniRule annotation

Catalytic activityi

2'-(5-triphosphoribosyl)-3'-dephospho-CoA + citrate lyase apo-[acyl-carrier protein] = citrate lyase holo-[acyl-carrier protein] + diphosphate.UniRule annotation

GO - Molecular functioni

  1. holo-citrate lyase synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. prosthetic group biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Enzyme and pathway databases

BioCyciSPYO186103:GHJG-984-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable apo-citrate lyase phosphoribosyl-dephospho-CoA transferaseUniRule annotation (EC:2.7.7.61UniRule annotation)
Alternative name(s):
Apo-ACP nucleodityltransferaseUniRule annotation
Holo-ACP synthaseUniRule annotation
Holo-citrate lyase synthaseUniRule annotation
Gene namesi
Name:citXUniRule annotation
Ordered Locus Names:spyM18_1141
OrganismiStreptococcus pyogenes serotype M18 (strain MGAS8232)
Taxonomic identifieri186103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000820: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192Probable apo-citrate lyase phosphoribosyl-dephospho-CoA transferasePRO_0000214691Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi186103.spyM18_1141.

Family & Domainsi

Sequence similaritiesi

Belongs to the CitX family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3697.
HOGENOMiHOG000130710.
KOiK05964.
OMAiLWQHRWP.
OrthoDBiEOG6T7NCD.

Family and domain databases

HAMAPiMF_00398. CitX.
InterProiIPR005551. CitX.
[Graphical view]
PfamiPF03802. CitX. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03124. citrate_citX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8P0Z2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCKDTYFSGE AIQLSDMLRA REERALRQLH LLKEYPEGSL LSVTMNIPGP
60 70 80 90 100
IKTSPKLLEA FDIVIKAIQT ALADDKICYQ LRLLPTTGYE YYLITSLPSQ
110 120 130 140 150
DLKLKMIALE TDLPIGRLMD LDVLVLSNGR PSPISRTTLG APPRQCFICS
160 170 180 190
KEAKVCGRLR KHSVEEMQTA ISKLLHSFFN KDNQSSSSDK TG
Length:192
Mass (Da):21,506
Last modified:October 1, 2002 - v1
Checksum:i97AB5835CC1C3B7C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009949 Genomic DNA. Translation: AAL97761.1.
RefSeqiNP_607262.1. NC_003485.1.
WP_011017787.1. NC_003485.1.

Genome annotation databases

EnsemblBacteriaiAAL97761; AAL97761; spyM18_1141.
GeneIDi993940.
KEGGispm:spyM18_1141.
PATRICi19748859. VBIStrPyo4396_1016.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009949 Genomic DNA. Translation: AAL97761.1 .
RefSeqi NP_607262.1. NC_003485.1.
WP_011017787.1. NC_003485.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 186103.spyM18_1141.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL97761 ; AAL97761 ; spyM18_1141 .
GeneIDi 993940.
KEGGi spm:spyM18_1141.
PATRICi 19748859. VBIStrPyo4396_1016.

Phylogenomic databases

eggNOGi COG3697.
HOGENOMi HOG000130710.
KOi K05964.
OMAi LWQHRWP.
OrthoDBi EOG6T7NCD.

Enzyme and pathway databases

BioCyci SPYO186103:GHJG-984-MONOMER.

Family and domain databases

HAMAPi MF_00398. CitX.
InterProi IPR005551. CitX.
[Graphical view ]
Pfami PF03802. CitX. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03124. citrate_citX. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks."
    Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S., Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D., Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A., Veasy L.G., Musser J.M.
    Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MGAS8232.

Entry informationi

Entry nameiCITX_STRP8
AccessioniPrimary (citable) accession number: Q8P0Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3