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Q8P0Z2

- CITX_STRP8

UniProt

Q8P0Z2 - CITX_STRP8

Protein

Probable apo-citrate lyase phosphoribosyl-dephospho-CoA transferase

Gene

citX

Organism
Streptococcus pyogenes serotype M18 (strain MGAS8232)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Transfers 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A on a serine residue to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield holo-acyl carrier protein.UniRule annotation

    Catalytic activityi

    2'-(5-triphosphoribosyl)-3'-dephospho-CoA + citrate lyase apo-[acyl-carrier-protein] = citrate lyase holo-[acyl-carrier-protein] + diphosphate.UniRule annotation

    GO - Molecular functioni

    1. holo-citrate lyase synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. prosthetic group biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciSPYO186103:GHJG-984-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable apo-citrate lyase phosphoribosyl-dephospho-CoA transferaseUniRule annotation (EC:2.7.7.61UniRule annotation)
    Alternative name(s):
    Apo-ACP nucleodityltransferaseUniRule annotation
    Holo-ACP synthaseUniRule annotation
    Holo-citrate lyase synthaseUniRule annotation
    Gene namesi
    Name:citXUniRule annotation
    Ordered Locus Names:spyM18_1141
    OrganismiStreptococcus pyogenes serotype M18 (strain MGAS8232)
    Taxonomic identifieri186103 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000820: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 192192Probable apo-citrate lyase phosphoribosyl-dephospho-CoA transferasePRO_0000214691Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi186103.spyM18_1141.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CitX family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3697.
    HOGENOMiHOG000130710.
    KOiK05964.
    OMAiLWQHRWP.
    OrthoDBiEOG6T7NCD.

    Family and domain databases

    HAMAPiMF_00398. CitX.
    InterProiIPR005551. CitX.
    [Graphical view]
    PfamiPF03802. CitX. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03124. citrate_citX. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8P0Z2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCKDTYFSGE AIQLSDMLRA REERALRQLH LLKEYPEGSL LSVTMNIPGP    50
    IKTSPKLLEA FDIVIKAIQT ALADDKICYQ LRLLPTTGYE YYLITSLPSQ 100
    DLKLKMIALE TDLPIGRLMD LDVLVLSNGR PSPISRTTLG APPRQCFICS 150
    KEAKVCGRLR KHSVEEMQTA ISKLLHSFFN KDNQSSSSDK TG 192
    Length:192
    Mass (Da):21,506
    Last modified:October 1, 2002 - v1
    Checksum:i97AB5835CC1C3B7C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009949 Genomic DNA. Translation: AAL97761.1.
    RefSeqiNP_607262.1. NC_003485.1.
    WP_011017787.1. NC_003485.1.

    Genome annotation databases

    EnsemblBacteriaiAAL97761; AAL97761; spyM18_1141.
    GeneIDi993940.
    KEGGispm:spyM18_1141.
    PATRICi19748859. VBIStrPyo4396_1016.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009949 Genomic DNA. Translation: AAL97761.1 .
    RefSeqi NP_607262.1. NC_003485.1.
    WP_011017787.1. NC_003485.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 186103.spyM18_1141.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL97761 ; AAL97761 ; spyM18_1141 .
    GeneIDi 993940.
    KEGGi spm:spyM18_1141.
    PATRICi 19748859. VBIStrPyo4396_1016.

    Phylogenomic databases

    eggNOGi COG3697.
    HOGENOMi HOG000130710.
    KOi K05964.
    OMAi LWQHRWP.
    OrthoDBi EOG6T7NCD.

    Enzyme and pathway databases

    BioCyci SPYO186103:GHJG-984-MONOMER.

    Family and domain databases

    HAMAPi MF_00398. CitX.
    InterProi IPR005551. CitX.
    [Graphical view ]
    Pfami PF03802. CitX. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03124. citrate_citX. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks."
      Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S., Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D., Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A., Veasy L.G., Musser J.M.
      Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MGAS8232.

    Entry informationi

    Entry nameiCITX_STRP8
    AccessioniPrimary (citable) accession number: Q8P0Z2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3