Q8P0Z2 (CITX_STRP8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
EC=2.7.7.61

Alternative name(s):
Apo-ACP nucleodityltransferase
Holo-ACP synthase
Holo-citrate lyase synthase

Gene names

Name:	citX
Ordered Locus Names:	spyM18_1141

Organism

Streptococcus pyogenes serotype M18 [Complete proteome] [HAMAP]

Taxonomic identifier

301451 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	192 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transfers 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A on a serine residue to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield holo-acyl carrier protein By similarity. HAMAP MF_00398
Catalytic activity	2'-(5-triphosphoribosyl)-3'-dephospho-CoA + citrate lyase apo-[acyl-carrier-protein] = citrate lyase holo-[acyl-carrier-protein] + diphosphate. HAMAP MF_00398
Sequence similarities	Belongs to the CitX family.

Ontologies

Keywords
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	prosthetic group biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	holo-citrate lyase synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 192	192	Probable apo-citrate lyase phosphoribosyl-dephospho-CoA transferase HAMAP MF_00398		PRO_0000214691

Sequences

	Sequence		Length	Mass (Da)
	Q8P0Z2 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 97AB5835CC1C3B7C	FASTA	192	21,506
	10 20 30 40 50 60 MCKDTYFSGE AIQLSDMLRA REERALRQLH LLKEYPEGSL LSVTMNIPGP IKTSPKLLEA 70 80 90 100 110 120 FDIVIKAIQT ALADDKICYQ LRLLPTTGYE YYLITSLPSQ DLKLKMIALE TDLPIGRLMD 130 140 150 160 170 180 LDVLVLSNGR PSPISRTTLG APPRQCFICS KEAKVCGRLR KHSVEEMQTA ISKLLHSFFN 190 KDNQSSSSDK TG

References

[1]

"Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks." Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S., Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D., Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A., Veasy L.G., Musser J.M. Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002) [PubMed: 11917108] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MGAS8232 / Serotype M18.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009949 Genomic DNA. Translation: AAL97761.1.
RefSeq	NP_607262.1. NC_003485.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000029846; EBSTRP00000028768; EBSTRG00000029846.
GeneID	993940.
GenomeReviews	Gene locus spyM18_1141 in contig AE009949_GR.
KEGG	spm:spyM18_1141.
PATRIC	19748859. VBIStrPyo4396_1016.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000028802.
HOGENOM	HBG698187.
OMA	PIGRLMD.
ProtClustDB	PRK01392.
Enzyme and pathway databases
BioCyc	SPYO186103:SPYM18_1141-MONOMER.
Family and domain databases
HAMAP	MF_00398. CitX. [Tree]
InterPro	IPR005551. CitX. [Graphical view]
KO	K05964.
Pfam	PF03802. CitX. 1 hit. [Graphical view]
TIGRFAMs	TIGR03124. Citrate_citX. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CITX_STRP8

Accession

Primary (citable) accession number: Q8P0Z2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2002
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program