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Protein

Formate--tetrahydrofolate ligase 1

Gene

fhs1

Organism
Streptococcus pyogenes serotype M18 (strain MGAS8232)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPYO186103:G1FZQ-1035-MONOMER
UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase 1UniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetase 1UniRule annotation
Short name:
FHS 1UniRule annotation
Short name:
FTHFS 1UniRule annotation
Gene namesi
Name:fhs1UniRule annotation
Synonyms:fhs
Ordered Locus Names:spyM18_1165
OrganismiStreptococcus pyogenes serotype M18 (strain MGAS8232)
Taxonomic identifieri186103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001993911 – 556Formate--tetrahydrofolate ligase 1Add BLAST556

Proteomic databases

PRIDEiQ8P0X5

Structurei

3D structure databases

ProteinModelPortaliQ8P0X5
SMRiQ8P0X5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000040280
KOiK01938
OMAiCGEIMTM

Family and domain databases

CDDicd00477 FTHFS, 1 hit
HAMAPiMF_01543 FTHFS, 1 hit
InterProiView protein in InterPro
IPR000559 Formate_THF_ligase
IPR020628 Formate_THF_ligase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01268 FTHFS, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00721 FTHFS_1, 1 hit
PS00722 FTHFS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8P0X5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSDIEIAQS VALQPITDIV KKVGIDGDDI ELYGKYKAKL SFEKMKAVEA
60 70 80 90 100
NEPGKLLLVT AINPTPAGEG KSTMSIGLAD ALNQMGKKTM LALREPSLGP
110 120 130 140 150
VMGIKGGAAG GGYAQVLPME DINLHFTGDM HAITTANNAL SALIDNHLQQ
160 170 180 190 200
GNDLGIDPRR IIWKRVLDLN DRALRQVIVG LGSPVNGVPR EDGFDITVAS
210 220 230 240 250
EIMAILCLAT DLKDLKKRLA DIVVAYTYDR KPVYVRDLKV EGALTLILKD
260 270 280 290 300
AIKPNLVQTI YGTPALIHGG PFANIAHGCN SVLATSTALR LADYTVTEAG
310 320 330 340 350
FGADLGAEKF LNIKVPNLPK APDAIVIVAT LRALKMHGGV AKSDLAAENC
360 370 380 390 400
EAVRLGFANL KRHVENMRQF KVPVVVAINE FVADTEAEIA TLKALCEEIK
410 420 430 440 450
VPVELASVWA NGAEGGLALA KTAVRVIDQE AADYKRLYSD EDTLEEKVIN
460 470 480 490 500
IVTQIYGGKA VQFGPKAKTQ LKQFAEFGWD KLPVCMAKTQ YSFSDNPSLL
510 520 530 540 550
GAPTDFDITI REFVPKTGAG FIVGLTGDVM TMPGLPKVPA AMAMDVAENG

TALGLF
Length:556
Mass (Da):59,503
Last modified:October 1, 2002 - v1
Checksum:iDBC6D12168F0C3F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009949 Genomic DNA Translation: AAL97781.1
RefSeqiWP_011017800.1, NC_003485.1

Genome annotation databases

EnsemblBacteriaiAAL97781; AAL97781; spyM18_1165
KEGGispm:spyM18_1165

Similar proteinsi

Entry informationi

Entry nameiFTHS1_STRP8
AccessioniPrimary (citable) accession number: Q8P0X5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health