Q8P046 (MSRAB_STRP8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA/MsrB

Including the following 2 domains:

1. Peptide methionine sulfoxide reductase MsrA
   Short name=Protein-methionine-S-oxide reductase
   EC=1.8.4.11
   Alternative name(s):
   Peptide-methionine (S)-S-oxide reductase
   Short name=Peptide Met(O) reductase
2. Peptide methionine sulfoxide reductase MsrB
   EC=1.8.4.12
   Alternative name(s):
   Peptide-methionine (R)-S-oxide reductase

Gene names

Name:	msrAB
Ordered Locus Names:	spyM18_1571

Organism

Streptococcus pyogenes serotype M18 [Complete proteome] [HAMAP]

Taxonomic identifier

301451 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01400
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01400 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01400 Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin.
Sequence similarities	In the N-terminal section; belongs to the MsrA Met sulfoxide reductase family. In the C-terminal section; belongs to the MsrB Met sulfoxide reductase family.
Sequence caution	The sequence AAL98136.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological process	protein metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Peptide methionine sulfoxide reductase MsrA/MsrB HAMAP MF_01400		PRO_0000138524
Regions
	Region	1 – 153	153	Peptide methionine sulfoxide reductase A HAMAP MF_01400
	Region	170 – 293	124	Peptide methionine sulfoxide reductase B HAMAP MF_01400
Sites
	Active site	8	1	By similarity
	Active site	282	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8P046 [UniParc]. Last modified November 25, 2002. Version 2. Checksum: 2E1F1374F4028ADF	FASTA	309	35,133
	10 20 30 40 50 60 MIYLAGGCFW GVEEYFSQVD GVLDAVSGYA NGRGDTTNYQ LIHQTGHAET VEVAYDTNRI 70 80 90 100 110 120 SLKELLLHFF RIIDPTSLNK QGNDRGSQYR TGIYYTDKAD LAIIDEVFKE KAKDYKKKIV 130 140 150 160 170 180 VEKAPLKHFI KAEDYHQDYL KKNPNGYCHI DINQATYPVI DESKYPKPSA TEIKEKLSAD 190 200 210 220 230 240 EYRVTQKNET EKAFSNRYWD SFDAGIYVDV VTGEPLFSSK DKFESGCGWP SFSRPISPDV 250 260 270 280 290 300 VRYKEDKSFN MTRTEVRSRS GNSHLGHVFT DGPKDQGGLR YCINSLSITF IPKADMEAKG YGYLLSSVE

References

[1]

"Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks." Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S., Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D., Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A., Veasy L.G., Musser J.M. Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002) [PubMed: 11917108] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MGAS8232 / Serotype M18.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009949 Genomic DNA. Translation: AAL98136.1. Different initiation.
RefSeq	NP_607637.1. NC_003485.1.
3D structure databases
ProteinModelPortal	Q8P046.
SMR	Q8P046. Positions 1-159, 163-308.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000029541; EBSTRP00000028463; EBSTRG00000029541.
GeneID	994664.
GenomeReviews	Gene locus spyM18_1571 in contig AE009949_GR.
KEGG	spm:spyM18_1571.
PATRIC	19749652. VBIStrPyo4396_1412.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000027538.
HOGENOM	HBG715255.
ProtClustDB	CLSK877225.
Enzyme and pathway databases
BioCyc	SPYO186103:SPYM18_1571-MONOMER.
Family and domain databases
HAMAP	MF_01400. MsrB. Fused. [Tree] MF_01401. MsrA. Fused. [Tree]
InterPro	IPR002579. Methionine_sulphoxide_MsrB. IPR011057. Mss4-like. IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit. G3DSA:2.170.150.20. MsrB. 1 hit.
KO	K12267.
Pfam	PF01625. PMSR. 1 hit. PF01641. SelR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit. SSF51316. Mss4_like. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit. TIGR00357. TIGR00357. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRAB_STRP8

Accession

Primary (citable) accession number: Q8P046

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2002
Last sequence update:	November 25, 2002
Last modified:	January 25, 2012
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program