Q8P031 (AROE_STRP8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	spyM18_1592

Organism

Streptococcus pyogenes serotype M18 [Complete proteome] [HAMAP]

Taxonomic identifier

301451 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 292	292	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000136043
Regions
	Nucleotide binding	135 – 139	5	NADP By similarity
Sites
	Active site	73	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8P031 [UniParc]. Last modified October 19, 2002. Version 1. Checksum: 1F7AD7859D9610CF	FASTA	292	31,289
	10 20 30 40 50 60 MSERLSGHTL LVSLLATPIR HSLSPKMHNE AYAKLGLDYA YLAFEVGTEQ LADAVQGIRA 70 80 90 100 110 120 LGIRGSNVSM PNKEAILPLL DDLSPAAELV GAVNTVVNKD GKGHLVGHIT DGIGALRALA 130 140 150 160 170 180 DEGVSVKNKI ITLAGVGGAG KAIAVQLAFD GAKEIRLFNR QATRLSSVQK LVTKLNQLTR 190 200 210 220 230 240 TKVTLQDLED QTAFKEAIRE SHLFIDATSV GMKPLENLSL ITDPELIRPD LVVFDIVYSP 250 260 270 280 290 AETKLLAFAR QHGAQKVING LGMVLYQGAE AFKLITGQDM PVDAIKPLLG DK

References

[1]

"Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks." Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S., Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D., Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A., Veasy L.G., Musser J.M. Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002) [PubMed: 11917108] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MGAS8232 / Serotype M18.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009949 Genomic DNA. Translation: AAL98153.1.
RefSeq	NP_607654.1. NC_003485.1.
3D structure databases
ProteinModelPortal	Q8P031.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000030789; EBSTRP00000029711; EBSTRG00000030789.
GeneID	994667.
GenomeReviews	Gene locus spyM18_1592 in contig AE009949_GR.
KEGG	spm:spyM18_1592.
PATRIC	19749690. VBIStrPyo4396_1430.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000027337.
HOGENOM	HBG553408.
OMA	SIYIDAT.
ProtClustDB	CLSK698780.
Enzyme and pathway databases
BioCyc	SPYO186103:SPYM18_1592-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_STRP8

Accession

Primary (citable) accession number: Q8P031

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	October 19, 2002
Last modified:	January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program