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Protein

Uncharacterized sensor-like histidine kinase MW0199

Gene

MW0199

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Probable member of the two-component regulatory system MW0199/MW0198. May activate MW0198 by phosphorylation (By similarity).By similarity

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Two-component regulatory system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-201-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized sensor-like histidine kinase MW0199 (EC:2.7.13.3)
Gene namesi
Ordered Locus Names:MW0199
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000418 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021HelicalSequence analysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518Uncharacterized sensor-like histidine kinase MW0199PRO_0000299124Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei325 – 3251Phosphohistidine; by autocatalysisBy similarity

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ8NYJ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini297 – 513217Histidine kinaseAdd
BLAST

Sequence similaritiesi

Contains 1 histidine kinase domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000279740.
OMAiWVEHRTI.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
InterProiIPR003594. HATPase_C.
IPR010559. Sig_transdc_His_kin_internal.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF06580. His_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NYJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAYKPYRHQ LRRSLFASTI FPVFLVIIIG LVSFYAIYIW IEHRTIHQHV
60 70 80 90 100
DESQSSLHHT EKQIQTFITQ HNNSFQELDL TNHHDVTATK RGLLKLIHQQ
110 120 130 140 150
PATLYYELSG PNQFITNNYE HLNTKNMYLF STHQLKFKNS TYMLKIYMAN
160 170 180 190 200
TPRLSEIKKD SRQFALIVDQ YDNILYANDD RFTIGEKYRP QQFGFMNESV
210 220 230 240 250
KLNHADHRLI IYKDIHENIE DGITLLIVMA VVLVLLVIFG FISADNMAKR
260 270 280 290 300
QTKDIETIIQ KIYYAKNRHL GTYTPLKNNS ELEEINNYIY DLFESNEQLI
310 320 330 340 350
HSIEHTERRL RDIQLKEIER QFQPHFLFNT MQTIQYLITL SPKLAQTVVQ
360 370 380 390 400
QLSQMLRYSL RTNSHTVELN EELNYIEQYV AIQNIRFDDM IKLHIESSEE
410 420 430 440 450
ARHQTIGKMM LQPLIENAIK HGRDTESLDI TIRLTLARQN LHVLVCDNGI
460 470 480 490 500
GMSSSRLQYV RQSLNNDVFD TKHLGLNHLH NKAMIQYGSH ARLHIFSKRN
510
QGTLICYKIP LSRGNVDV
Length:518
Mass (Da):60,948
Last modified:October 1, 2002 - v1
Checksum:i29A778EB6AB7A908
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB94064.1.
RefSeqiWP_000127997.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB94064; BAB94064; BAB94064.
PATRICi19566866. VBIStaAur44266_0215.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB94064.1.
RefSeqiWP_000127997.1. NC_003923.1.

3D structure databases

ProteinModelPortaliQ8NYJ8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB94064; BAB94064; BAB94064.
PATRICi19566866. VBIStaAur44266_0215.

Phylogenomic databases

HOGENOMiHOG000279740.
OMAiWVEHRTI.

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-201-MONOMER.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
InterProiIPR003594. HATPase_C.
IPR010559. Sig_transdc_His_kin_internal.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF06580. His_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiY199_STAAW
AccessioniPrimary (citable) accession number: Q8NYJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.