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Protein

Protein EssC

Gene

essC

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Required for secretion of EsxA and EsxB.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Virulence

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-265-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein EssC
Gene namesi
Name:essC
Ordered Locus Names:MW0263
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000418 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei240 – 26021HelicalSequence analysisAdd
BLAST
Transmembranei261 – 28121HelicalSequence analysisAdd
BLAST
Transmembranei503 – 52321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14791479Protein EssCPRO_0000098335Add
BLAST

Structurei

Secondary structure

1
1479
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 87Combined sources
Beta strandi11 – 166Combined sources
Beta strandi23 – 275Combined sources
Beta strandi31 – 344Combined sources
Beta strandi42 – 465Combined sources
Beta strandi52 – 543Combined sources
Beta strandi60 – 667Combined sources
Beta strandi68 – 7811Combined sources
Helixi79 – 813Combined sources
Beta strandi82 – 865Combined sources
Beta strandi92 – 998Combined sources
Beta strandi102 – 1054Combined sources
Beta strandi113 – 1164Combined sources
Helixi118 – 1203Combined sources
Helixi121 – 1244Combined sources
Beta strandi126 – 1305Combined sources
Beta strandi137 – 1393Combined sources
Beta strandi146 – 1527Combined sources
Beta strandi156 – 1594Combined sources
Beta strandi162 – 1665Combined sources
Beta strandi168 – 1747Combined sources
Beta strandi180 – 1834Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WV3X-ray1.75A1-230[»]
ProteinModelPortaliQ8NYF3.
SMRiQ8NYF3. Positions 1-186.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8NYF3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini652 – 846195FtsK 1PROSITE-ProRule annotationAdd
BLAST
Domaini997 – 1183187FtsK 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 FtsK domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000119940.
OMAiWEWMKWL.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR023839. Firmicutes_EssC_C.
IPR022206. Firmicutes_EssC_N.
IPR002543. FtsK_dom.
IPR027417. P-loop_NTPase.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF01580. FtsK_SpoIIIE. 2 hits.
PF12538. FtsK_SpoIIIE_N. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 2 hits.
SSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR03928. T7_EssCb_Firm. 1 hit.
PROSITEiPS50901. FTSK. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NYF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHKLIIKYNK QLKMLNLRDG KTYTISEDER ADITLKSLGE VIHLEQNNQG
60 70 80 90 100
TWQANHTSIN KVLVRKGDLD DITLQLYTEA DYASFAYPSI QDTMTIGPNA
110 120 130 140 150
YDDMVIQSLM NAIIIKDFQS IQESQYVRIV HDKNTDVYIN YELQEQLTNK
160 170 180 190 200
AYIGDHIYVE GIWLEVQADG LNVLSQNTVA SSLIRLTQEM PHAQADDYNT
210 220 230 240 250
YHRSPRIIHR EPTDDIKIER PPQPIQKNNT VIWRSIIPPL VMIALTVVIF
260 270 280 290 300
LVRPIGIYIL MMIGMSSVTI VFGITTYFSE KKKYNKDVEK REKDYKDYLD
310 320 330 340 350
NKSKEINKAI KAQRFSLNYH YPTVAEIKDI VETKAPRIYE KTSHHHDFLH
360 370 380 390 400
YKLGIANVEK SFKLDYQEEE FNQRRDELFD DAKELYEFYT DVEQAPLIND
410 420 430 440 450
LNHGPIAYIG ARHLILEELE KMLIQLSIFH SYHDLEFLFV TREDEVETLK
460 470 480 490 500
WARWLPHMTL RGQNIRGFVY NQRTRDQILT SIYSMIKERI QAVRERSKSN
510 520 530 540 550
EQIIFTPQLV FVITDMSLII DHVILEYVNQ DLSEYGISLI FVEDVIESLP
560 570 580 590 600
EHVDTIIDIK SRTEGELITK EKELVQLKFT PENIDNVDKE YIARRLANLI
610 620 630 640 650
HVEHLKNAIP DSITFLEMYN VKEVDQLDVV NRWRQNETYK TMAVPLGVRG
660 670 680 690 700
KDDILSLNLH EKAHGPHGLV AGTTGSGKSE IIQSYILSLA INFHPHEVAF
710 720 730 740 750
LLIDYKGGGM ANLFKDLVHL VGTITNLDGD EAMRALTSIK AELRKRQRLF
760 770 780 790 800
GEHDVNHINQ YHKLFKEGIA TEPMPHLFII SDEFAELKSE QPDFMKELVS
810 820 830 840 850
TARIGRSLGI HLILATQKPS GVVDDQIWSN SKFKLALKVQ DRQDSNEILK
860 870 880 890 900
TPDAADITLP GRAYLQVGNN EIYELFQSAW SGATYDIEGD KLEVEDKTIY
910 920 930 940 950
MINDYGQLQA INKDLSGLED EETKENQTEL EAVIDHIESI TTRLEIEEVK
960 970 980 990 1000
RPWLPPLPEN VYQEDLVETD FRKLWSDDAK EVELTLGLKD VPEEQYQGPM
1010 1020 1030 1040 1050
VLQLKKAGHI ALIGSPGYGR TTFLHNIIFD VARHHRPDQA HMYLFDFGTN
1060 1070 1080 1090 1100
GLMPVTDIPH VADYFTVDQE DKIAKAIRIF NDEIDRRKKI LSQYRVTSIS
1110 1120 1130 1140 1150
EYRKLTGETI PHVFILIDNF DAVKDSPFQE VFENMMIKMT REGLALDMQV
1160 1170 1180 1190 1200
TLTASRANAM KTPMYINMKT RIAMFLYDKS EVSNVVGQQK FAVKDVVGRA
1210 1220 1230 1240 1250
LLSSDDNVSF HIGQPFKHDE TKSYNDQIND EVSAMTEFYK GETPSDIPMM
1260 1270 1280 1290 1300
PDEIKYEDYR ESLSLPDIVA NGALPIGLDY EGVTLQKIKL TEPAMISSEN
1310 1320 1330 1340 1350
PREIAHIAEI MMKEIDILNE KYAICIADSS GEFKAYRHQV ANFAEEREDI
1360 1370 1380 1390 1400
KAIHQLMIED LKQREMDGPF EKDSLYIIND FKTFIDCTYI PEDDVKKLIT
1410 1420 1430 1440 1450
KGPELGLNIL FVGIHKELID AYDKQIDVAR KMINQFSIGI RISDQQFFKF
1460 1470
RFIQREPVIK ENEAYMVANQ AYQKIRWFK
Length:1,479
Mass (Da):170,891
Last modified:October 1, 2002 - v1
Checksum:i96A9A5BB1471B634
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB94128.1.
RefSeqiWP_000549274.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB94128; BAB94128; BAB94128.
PATRICi19566998. VBIStaAur44266_0281.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB94128.1.
RefSeqiWP_000549274.1. NC_003923.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WV3X-ray1.75A1-230[»]
ProteinModelPortaliQ8NYF3.
SMRiQ8NYF3. Positions 1-186.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB94128; BAB94128; BAB94128.
PATRICi19566998. VBIStaAur44266_0281.

Phylogenomic databases

HOGENOMiHOG000119940.
OMAiWEWMKWL.

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-265-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ8NYF3.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR023839. Firmicutes_EssC_C.
IPR022206. Firmicutes_EssC_N.
IPR002543. FtsK_dom.
IPR027417. P-loop_NTPase.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF01580. FtsK_SpoIIIE. 2 hits.
PF12538. FtsK_SpoIIIE_N. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 2 hits.
SSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR03928. T7_EssCb_Firm. 1 hit.
PROSITEiPS50901. FTSK. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiESSC_STAAW
AccessioniPrimary (citable) accession number: Q8NYF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.