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Q8NYC2 (LIP2_STAAW) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Lipase 2
EC=3.1.1.3
Alternative name(s):
Glycerol ester hydrolase 2
Gene names
Name:lip2
Synonyms:geh
Ordered Locus Names:MW0297
OrganismStaphylococcus aureus (strain MW2) [Complete proteome] [HAMAP]
Taxonomic identifier196620 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length690 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the AB hydrolase superfamily. Lipase family.

Ontologies

Keywords
   Biological processLipid degradation
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
   PTMZymogen
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processlipid catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: InterPro

   Molecular functiontriglyceride lipase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3737 Potential
Propeptide38 – 295258 By similarity
PRO_0000017754
Chain296 – 690395Lipase 2
PRO_0000017755

Sites

Active site4121Charge relay system By similarity
Active site6451Charge relay system By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8NYC2 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 36FFB5E0BB434CCA

FASTA69076,522
        10         20         30         40         50         60 
MLRGQEERKY SIRKYSIGVV SVLAATMFVV SSHEAQASEK TPTNAAVQKE TLNQPGEQGN 

        70         80         90        100        110        120 
AITSHQMQSG KQLDDMHKEN GKSGTVTEGK DTLQLSKYQS TQNSKTIRTQ NDNQVKQDSE 

       130        140        150        160        170        180 
RQGSKQSHQN NATNNTERQN DQVQNTHHAE RNGSQSTTSQ SNDVDKSQPS IPAQKVLPNH 

       190        200        210        220        230        240 
DKAAPTSTTP PSNDKTAPKS TKAQDATTDK HPNQQDTHQP AHQIIDAKQD DTVRQSEQKP 

       250        260        270        280        290        300 
QVGDLSKHID GQNSPEKPTD KNTDNKQLIK DALQAPKTRS TTNAAADAKK VRPLKANQVQ 

       310        320        330        340        350        360 
PLNKYPVVFV HGFLGLVGDN APALYPNYWG GNKFKVIEEL RKQGYNVHQA SVSAFGSNYD 

       370        380        390        400        410        420 
RAVELYYYIK GGRVDYGAAH AAKYGHERYG KTYKGIMPNW EPGKKVHLVG HSMGGQTIRL 

       430        440        450        460        470        480 
MEEFLRNGNK EEIAYHKAHG GEISPLFTGG HNNMVASITT LATPHNGSQA ADKFGNTEAV 

       490        500        510        520        530        540 
RKIMFALNRF MGNKYSNIDL GLTQWGFKQL PNESYIDYIK RVSKSKIWTS DDNAAYDLTL 

       550        560        570        580        590        600 
DGSAKLNNMT SMNPNITYTT YTGVSSHTGP LGYENPDLGT FFLMDTTSRI IGHDAREEWR 

       610        620        630        640        650        660 
KNDGVVPVIS SLHPSNQPFV NVTNDEPATR RGIWQVKPII QGWDHVDFIG VDFLDFKRKG 

       670        680        690 
AELANFYTGI INDLLRVEAT ESKGTQLKAS

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References

[1]"Genome and virulence determinants of high virulence community-acquired MRSA."
Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y., Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.
Lancet 359:1819-1827(2002) [PubMed: 12044378] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MW2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000033 Genomic DNA. Translation: BAB94162.1.
RefSeqNP_645114.1. NC_003923.1.

3D structure databases

ProteinModelPortalQ8NYC2.
SMRQ8NYC2. Positions 295-682.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8NYC2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000025113; EBSTAP00000024152; EBSTAG00000025112.
GeneID1002397.
GenomeReviewsGene locus MW0297 in contig BA000033_GR.
KEGGsam:MW0297.
PATRIC19567066. VBIStaAur44266_0315.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1075.
GeneTreeEBGT00050000023709.
HOGENOMHBG694146.
OMAETINRIG.
ProtClustDBCLSK2752181.

Enzyme and pathway databases

BioCycSAUR196620:MW0297-MONOMER.

Family and domain databases

InterProIPR005877. Gpos_YSIRK.
[Graphical view]
KOK01046.
PfamPF04650. YSIRK_signal. 1 hit.
[Graphical view]
TIGRFAMsTIGR01168. YSIRK_signal. 1 hit.
PROSITEPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLIP2_STAAW
AccessionPrimary (citable) accession number: Q8NYC2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: October 1, 2002
Last modified: January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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