Reviewed, UniProtKB/Swiss-Prot Q8NYC2 (LIP2_STAAW)

Names and origin

Protein names

Recommended name:
    Lipase 2
    EC=3.1.1.3
Alternative name(s):
    Glycerol ester hydrolase 2

Gene names

Name:	lip2
Synonyms:	geh
Ordered Locus Names:	MW0297

Organism

Staphylococcus aureus (strain MW2) [Complete proteome] [HAMAP]

Taxonomic identifier

196620 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	690 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Triacylglycerol + H2O = diacylglycerol + a carboxylate.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the AB hydrolase superfamily. Lipase family.

Ontologies

Keywords
Biological process	Lipid degradation
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase
PTM	Zymogen
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: InterPro
Molecular function	triglyceride lipase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 37	37	Potential
	Propeptide	38 – 295	258	By similarity		PRO_0000017754
	Chain	296 – 690	395	Lipase 2		PRO_0000017755
Sites
	Active site	412	1	Charge relay system By similarity
	Active site	645	1	Charge relay system By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8NYC2-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 36FFB5E0BB434CCA	FASTA	690	76,522
	10 20 30 40 50 60 MLRGQEERKY SIRKYSIGVV SVLAATMFVV SSHEAQASEK TPTNAAVQKE TLNQPGEQGN 70 80 90 100 110 120 AITSHQMQSG KQLDDMHKEN GKSGTVTEGK DTLQLSKYQS TQNSKTIRTQ NDNQVKQDSE 130 140 150 160 170 180 RQGSKQSHQN NATNNTERQN DQVQNTHHAE RNGSQSTTSQ SNDVDKSQPS IPAQKVLPNH 190 200 210 220 230 240 DKAAPTSTTP PSNDKTAPKS TKAQDATTDK HPNQQDTHQP AHQIIDAKQD DTVRQSEQKP 250 260 270 280 290 300 QVGDLSKHID GQNSPEKPTD KNTDNKQLIK DALQAPKTRS TTNAAADAKK VRPLKANQVQ 310 320 330 340 350 360 PLNKYPVVFV HGFLGLVGDN APALYPNYWG GNKFKVIEEL RKQGYNVHQA SVSAFGSNYD 370 380 390 400 410 420 RAVELYYYIK GGRVDYGAAH AAKYGHERYG KTYKGIMPNW EPGKKVHLVG HSMGGQTIRL 430 440 450 460 470 480 MEEFLRNGNK EEIAYHKAHG GEISPLFTGG HNNMVASITT LATPHNGSQA ADKFGNTEAV 490 500 510 520 530 540 RKIMFALNRF MGNKYSNIDL GLTQWGFKQL PNESYIDYIK RVSKSKIWTS DDNAAYDLTL 550 560 570 580 590 600 DGSAKLNNMT SMNPNITYTT YTGVSSHTGP LGYENPDLGT FFLMDTTSRI IGHDAREEWR 610 620 630 640 650 660 KNDGVVPVIS SLHPSNQPFV NVTNDEPATR RGIWQVKPII QGWDHVDFIG VDFLDFKRKG 670 680 690 AELANFYTGI INDLLRVEAT ESKGTQLKAS

References

[1]

"Genome and virulence determinants of high virulence community-acquired MRSA." Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y., Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K. Lancet 359:1819-1827(2002) [PubMed: 12044378] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000033 Genomic DNA. Translation: BAB94162.1.
RefSeq	NP_645114.1.
3D structure databases
HSSP	HSSP built from PDB template 1KU0 based on UniProtKB O66015.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8NYC2.
Genome annotation databases
GeneID	1002397.
GenomeReviews	Gene locus MW0297 in contig BA000033_GR.
KEGG	sam:MW0297.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8NYC2.
OMA	ETINRIG.
Enzyme and pathway databases
BioCyc	SAUR196620:MW0297-MON.
Family and domain databases
InterPro	IPR005877. Gpos_YSIRK. IPR008262. Lipase_Ser_AS. [Graphical view]
Pfam	PF04650. YSIRK_signal. 1 hit. [Graphical view]
TIGRFAMs	TIGR01168. YSIRK_signal. 1 hit.
PROSITE	PS00120. LIPASE_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LIP2_STAAW

Accession

Primary (citable) accession number: Q8NYC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2003
Last sequence update:	October 1, 2002
Last modified:	November 3, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)