Q8NYC2 (LIP2_STAAW) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 57.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Lipase 2 EC=3.1.1.3 Alternative name(s): Glycerol ester hydrolase 2 | ||||||
| Gene names |
| ||||||
| Organism | Staphylococcus aureus (strain MW2) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 196620 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Staphylococcus |
Protein attributes
| Sequence length | 690 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | Triacylglycerol + H2O = diacylglycerol + a carboxylate. |
| Subcellular location | Secreted By similarity. |
| Sequence similarities | Belongs to the AB hydrolase superfamily. Lipase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Lipid degradation |
| Cellular component | Secreted |
| Domain | Signal |
| Molecular function | Hydrolase |
| PTM | Zymogen |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell membraneInferred from electronic annotation. Source: InterPro |
| Molecular function | triglyceride lipase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 37 | 37 | Potential | ||||||
| Propeptide | 38 – 295 | 258 | By similarity | PRO_0000017754 | |||||
| Chain | 296 – 690 | 395 | Lipase 2 | PRO_0000017755 | |||||
Sites | |||||||||
| Active site | 412 | 1 | Charge relay system By similarity | ||||||
| Active site | 645 | 1 | Charge relay system By similarity | ||||||
Sequences
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References
| [1] | "Genome and virulence determinants of high virulence community-acquired MRSA." Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y., Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K. Lancet 359:1819-1827(2002) [PubMed: 12044378] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MW2. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BA000033 Genomic DNA. Translation: BAB94162.1. |
| RefSeq | NP_645114.1. NC_003923.1. |
3D structure databases | |
| ProteinModelPortal | Q8NYC2. |
| SMR | Q8NYC2. Positions 295-682. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q8NYC2. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBSTAT00000025113; EBSTAP00000024152; EBSTAG00000025112. |
| GeneID | 1002397. |
| GenomeReviews | Gene locus MW0297 in contig BA000033_GR. |
| KEGG | sam:MW0297. |
| PATRIC | 19567066. VBIStaAur44266_0315. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG1075. |
| GeneTree | EBGT00050000023709. |
| HOGENOM | HBG694146. |
| OMA | ETINRIG. |
| ProtClustDB | CLSK2752181. |
Enzyme and pathway databases | |
| BioCyc | SAUR196620:MW0297-MONOMER. |
Family and domain databases | |
| InterPro | IPR005877. Gpos_YSIRK. [Graphical view] |
| KO | K01046. |
| Pfam | PF04650. YSIRK_signal. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01168. YSIRK_signal. 1 hit. |
| PROSITE | PS00120. LIPASE_SER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | LIP2_STAAW | ||||||||
| Accession | Primary (citable) accession number: Q8NYC2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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