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Protein

N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase

Gene

tarA

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid.UniRule annotation

Catalytic activityi

UDP-N-acetyl-alpha-D-mannosamine + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = UDP + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol.UniRule annotation

Pathwayi: poly(ribitol phosphate) teichoic acid biosynthesis

This protein is involved in the pathway poly(ribitol phosphate) teichoic acid biosynthesis, which is part of Cell wall biogenesis.Curated
View all proteins of this organism that are known to be involved in the pathway poly(ribitol phosphate) teichoic acid biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell wall biogenesis/degradation, Teichoic acid biosynthesis

Enzyme and pathway databases

BioCyciSAUR196620:G1G3G-677-MONOMER.
UniPathwayiUPA00790.

Protein family/group databases

CAZyiGT26. Glycosyltransferase Family 26.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferaseUniRule annotation (EC:2.4.1.187UniRule annotation)
Alternative name(s):
N-acetylmannosaminyltransferaseUniRule annotation
UDP-N-acetylmannosamine transferaseUniRule annotation
UDP-N-acetylmannosamine:N-acetylglucosaminyl pyrophosphorylundecaprenol N-acetylmannosaminyltransferaseUniRule annotation
Gene namesi
Name:tarA
Ordered Locus Names:MW0598
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000418 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002084461 – 254N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferaseAdd BLAST254

Structurei

3D structure databases

SMRiQ8NXS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 26 family. TagA/TarA subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000075379.
KOiK05946.
OMAiPWRWRRM.

Family and domain databases

CDDicd06533. Glyco_transf_WecG_TagA. 1 hit.
HAMAPiMF_02070. TagA_TarA. 1 hit.
InterProiView protein in InterPro
IPR034714. TagA_TarA.
IPR004629. WecB_TagA_CpsF.
PANTHERiPTHR34136. PTHR34136. 1 hit.
PfamiView protein in Pfam
PF03808. Glyco_tran_WecB. 1 hit.
TIGRFAMsiTIGR00696. wecG_tagA_cpsF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NXS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVEERSNTA KVDILGVDFD NTTMLQMVEN IKTFFANQST NNLFIVTANP
60 70 80 90 100
EIVNYATTHQ AYLELINQAS YIVADGTGVV KASHRLKQPL AHRIPGIELM
110 120 130 140 150
DECLKIAHVN HQKVFLLGAT NEVVEAAQYA LQQRYPNISF AHHHGYIDLE
160 170 180 190 200
DETVVKRIKL FKPDYIFVGM GFPKQEEWIM THENQFESTV MMGVGGSLEV
210 220 230 240 250
FAGAKKRAPY IFRKLNIEWI YRALMDWKRI GRLKSIPIFM YKIAKAKRKI

KKAK
Length:254
Mass (Da):29,151
Last modified:October 1, 2002 - v1
Checksum:i99C014388CFA90FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB94463.1.
RefSeqiWP_000215390.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB94463; BAB94463; BAB94463.
KEGGisam:MW0598.

Similar proteinsi

Entry informationi

Entry nameiTARA_STAAW
AccessioniPrimary (citable) accession number: Q8NXS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 1, 2002
Last modified: February 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome