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Protein

Argininosuccinate synthase

Gene

argG

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851CitrullineUniRule annotation
Binding sitei115 – 1151ATP; via amide nitrogenUniRule annotation
Binding sitei117 – 1171AspartateUniRule annotation
Binding sitei121 – 1211AspartateUniRule annotation
Binding sitei121 – 1211CitrullineUniRule annotation
Binding sitei122 – 1221AspartateUniRule annotation
Binding sitei125 – 1251CitrullineUniRule annotation
Binding sitei173 – 1731CitrullineUniRule annotation
Binding sitei258 – 2581CitrullineUniRule annotation
Binding sitei270 – 2701CitrullineUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 169ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-865-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:MW0843
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000418 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401Argininosuccinate synthasePRO_0000148640Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi196620.MW0843.

Structurei

3D structure databases

ProteinModelPortaliQ8NXF2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiPAREWGM.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NXF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEKIVLAYS GGLDTSVAVQ WLIDKGYDVV ACCLDVGEGK DLDIVYKKAL
60 70 80 90 100
DMGAVECHII DATKEFSDEY VSYAIKGNLM YENAYPLVSA LSRPLIAKKL
110 120 130 140 150
VEIAEKTNSV GIAHGCTGKG NDQVRFEVAI KALNPSLKAF APVREWAWSR
160 170 180 190 200
EEEIDYAIKH NIPVSINHDS PYSIDQNLWG RANECGILED PYAAPPEDAF
210 220 230 240 250
DLTNALEETP DAADEIILTF DKGIPVQIDG KTYELDDLIL TLNALAGKHG
260 270 280 290 300
IGRIDHVENR LVGIKSREIY EAPAAEVILK AHKALETITL TKDVAHFKPI
310 320 330 340 350
IEKQFAEQLY NGLWFSPLTD SLKLFIDSTQ QYVSGDVRIK LFKGNAIVNG
360 370 380 390 400
RKSPYTLYDE KLATYTKEDA FNQDAAVGFI DIYGLPTQVN SMLHGGYSNE

Q
Length:401
Mass (Da):44,441
Last modified:October 19, 2002 - v1
Checksum:iEBAE25357016B0AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB94708.1.
RefSeqiNP_645660.1. NC_003923.1.
WP_000660041.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB94708; BAB94708; BAB94708.
KEGGisam:MW0843.
PATRICi19568253. VBIStaAur44266_0888.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB94708.1.
RefSeqiNP_645660.1. NC_003923.1.
WP_000660041.1. NC_003923.1.

3D structure databases

ProteinModelPortaliQ8NXF2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi196620.MW0843.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB94708; BAB94708; BAB94708.
KEGGisam:MW0843.
PATRICi19568253. VBIStaAur44266_0888.

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiPAREWGM.
OrthoDBiEOG6K9QCV.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.
BioCyciSAUR196620:GJ9Z-865-MONOMER.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MW2.

Entry informationi

Entry nameiASSY_STAAW
AccessioniPrimary (citable) accession number: Q8NXF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: May 27, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.