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Q8NXE1

- FABF_STAAW

UniProt

Q8NXE1 - FABF_STAAW

Protein

3-oxoacyl-[acyl-carrier-protein] synthase 2

Gene

fabF

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.By similarity

    Catalytic activityi

    (Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei165 – 1651PROSITE-ProRule annotation

    GO - Molecular functioni

    1. beta-ketoacyl-acyl-carrier-protein synthase II activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciSAUR196620:GJ9Z-888-MONOMER.
    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-oxoacyl-[acyl-carrier-protein] synthase 2 (EC:2.3.1.179)
    Alternative name(s):
    3-oxoacyl-[acyl-carrier-protein] synthase II
    Beta-ketoacyl-ACP synthase II
    Short name:
    KAS II
    Gene namesi
    Name:fabF
    Ordered Locus Names:MW0866
    OrganismiStaphylococcus aureus (strain MW2)
    Taxonomic identifieri196620 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000418: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4144143-oxoacyl-[acyl-carrier-protein] synthase 2PRO_0000180325Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi196620.MW0866.

    Structurei

    Secondary structure

    1
    414
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi7 – 1610
    Beta strandi19 – 213
    Helixi22 – 309
    Beta strandi36 – 383
    Beta strandi51 – 533
    Helixi60 – 623
    Turni67 – 715
    Helixi74 – 9017
    Turni96 – 983
    Helixi99 – 1013
    Beta strandi102 – 1076
    Helixi113 – 12614
    Helixi128 – 1303
    Helixi135 – 1395
    Helixi143 – 15210
    Beta strandi156 – 1594
    Helixi164 – 1663
    Helixi167 – 18014
    Beta strandi185 – 1939
    Helixi198 – 2069
    Turni216 – 2183
    Beta strandi235 – 2439
    Helixi244 – 2507
    Beta strandi256 – 26510
    Beta strandi270 – 2723
    Helixi275 – 2773
    Helixi278 – 29114
    Helixi295 – 2973
    Beta strandi300 – 3023
    Helixi309 – 32315
    Helixi324 – 3274
    Beta strandi331 – 3333
    Helixi336 – 3394
    Helixi343 – 3453
    Helixi346 – 36015
    Beta strandi382 – 3843
    Beta strandi391 – 3988
    Helixi400 – 4023
    Beta strandi403 – 4108

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2GQDX-ray2.30A/B1-414[»]
    ProteinModelPortaliQ8NXE1.
    SMRiQ8NXE1. Positions 4-414.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8NXE1.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-ketoacyl-ACP synthases family.Curated

    Phylogenomic databases

    eggNOGiCOG0304.
    HOGENOMiHOG000060166.
    KOiK09458.
    OMAiHAQKRNA.
    OrthoDBiEOG6DG2SR.

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR017568. 3-oxoacyl-ACP_synth-2.
    IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000447. KAS_II. 1 hit.
    SUPFAMiSSF53901. SSF53901. 2 hits.
    TIGRFAMsiTIGR03150. fabF. 1 hit.
    PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NXE1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQNKRVVIT GMGALSPIGN DVKTTWENAL KGVNGIDKIT RIDTEPYSVH    50
    LAGELKNFNI EDHIDKKEAR RMDRFTQYAI VAAREAVKDA QLDINENTAD 100
    RIGVWIGSGI GGMETFEIAH KQLMDKGPRR VSPFFVPMLI PDMATGQVSI 150
    DLGAKGPNGA TVTACATGTN SIGEAFKIVQ RGDADAMITG GTEAPITHMA 200
    IAGFSASRAL STNDDIETAC RPFQEGRDGF VMGEGAGILV IESLESAQAR 250
    GANIYAEIVG YGTTGDAYHI TAPAPEGEGG SRAMQAAMDD AGIEPKDVQY 300
    LNAHGTSTPV GDLNEVKAIK NTFGEAAKHL KVSSTKSMTG HLLGATGGIE 350
    AIFSALSIKD SKVAPTIHAV TPDPECDLDI VPNEAQDLDI TYAMSNSLGF 400
    GGHNAVLVFK KFEA 414
    Length:414
    Mass (Da):43,739
    Last modified:October 1, 2002 - v1
    Checksum:i2DB06BB5DD48D175
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000033 Genomic DNA. Translation: BAB94731.1.
    RefSeqiNP_645683.1. NC_003923.1.

    Genome annotation databases

    EnsemblBacteriaiBAB94731; BAB94731; BAB94731.
    GeneIDi1002978.
    KEGGisam:MW0866.
    PATRICi19568299. VBIStaAur44266_0911.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000033 Genomic DNA. Translation: BAB94731.1 .
    RefSeqi NP_645683.1. NC_003923.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2GQD X-ray 2.30 A/B 1-414 [» ]
    ProteinModelPortali Q8NXE1.
    SMRi Q8NXE1. Positions 4-414.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196620.MW0866.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB94731 ; BAB94731 ; BAB94731 .
    GeneIDi 1002978.
    KEGGi sam:MW0866.
    PATRICi 19568299. VBIStaAur44266_0911.

    Phylogenomic databases

    eggNOGi COG0304.
    HOGENOMi HOG000060166.
    KOi K09458.
    OMAi HAQKRNA.
    OrthoDBi EOG6DG2SR.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .
    BioCyci SAUR196620:GJ9Z-888-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q8NXE1.

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR017568. 3-oxoacyl-ACP_synth-2.
    IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000447. KAS_II. 1 hit.
    SUPFAMi SSF53901. SSF53901. 2 hits.
    TIGRFAMsi TIGR03150. fabF. 1 hit.
    PROSITEi PS00606. B_KETOACYL_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MW2.

    Entry informationi

    Entry nameiFABF_STAAW
    AccessioniPrimary (citable) accession number: Q8NXE1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3