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Q8NXE1

- FABF_STAAW

UniProt

Q8NXE1 - FABF_STAAW

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Protein

3-oxoacyl-[acyl-carrier-protein] synthase 2

Gene

fabF

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.By similarity

Catalytic activityi

(Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei165 – 1651PROSITE-ProRule annotation

GO - Molecular functioni

  1. beta-ketoacyl-acyl-carrier-protein synthase II activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-888-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 2 (EC:2.3.1.179)
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase II
Beta-ketoacyl-ACP synthase II
Short name:
KAS II
Gene namesi
Name:fabF
Ordered Locus Names:MW0866
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000418: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4144143-oxoacyl-[acyl-carrier-protein] synthase 2PRO_0000180325Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196620.MW0866.

Structurei

Secondary structure

1
414
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 1610
Beta strandi19 – 213
Helixi22 – 309
Beta strandi36 – 383
Beta strandi51 – 533
Helixi60 – 623
Turni67 – 715
Helixi74 – 9017
Turni96 – 983
Helixi99 – 1013
Beta strandi102 – 1076
Helixi113 – 12614
Helixi128 – 1303
Helixi135 – 1395
Helixi143 – 15210
Beta strandi156 – 1594
Helixi164 – 1663
Helixi167 – 18014
Beta strandi185 – 1939
Helixi198 – 2069
Turni216 – 2183
Beta strandi235 – 2439
Helixi244 – 2507
Beta strandi256 – 26510
Beta strandi270 – 2723
Helixi275 – 2773
Helixi278 – 29114
Helixi295 – 2973
Beta strandi300 – 3023
Helixi309 – 32315
Helixi324 – 3274
Beta strandi331 – 3333
Helixi336 – 3394
Helixi343 – 3453
Helixi346 – 36015
Beta strandi382 – 3843
Beta strandi391 – 3988
Helixi400 – 4023
Beta strandi403 – 4108

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GQDX-ray2.30A/B1-414[»]
ProteinModelPortaliQ8NXE1.
SMRiQ8NXE1. Positions 4-414.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8NXE1.

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-ketoacyl-ACP synthases family.Curated

Phylogenomic databases

eggNOGiCOG0304.
HOGENOMiHOG000060166.
KOiK09458.
OMAiHAQKRNA.
OrthoDBiEOG6DG2SR.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR017568. 3-oxoacyl-ACP_synth-2.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000447. KAS_II. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR03150. fabF. 1 hit.
PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NXE1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQNKRVVIT GMGALSPIGN DVKTTWENAL KGVNGIDKIT RIDTEPYSVH
60 70 80 90 100
LAGELKNFNI EDHIDKKEAR RMDRFTQYAI VAAREAVKDA QLDINENTAD
110 120 130 140 150
RIGVWIGSGI GGMETFEIAH KQLMDKGPRR VSPFFVPMLI PDMATGQVSI
160 170 180 190 200
DLGAKGPNGA TVTACATGTN SIGEAFKIVQ RGDADAMITG GTEAPITHMA
210 220 230 240 250
IAGFSASRAL STNDDIETAC RPFQEGRDGF VMGEGAGILV IESLESAQAR
260 270 280 290 300
GANIYAEIVG YGTTGDAYHI TAPAPEGEGG SRAMQAAMDD AGIEPKDVQY
310 320 330 340 350
LNAHGTSTPV GDLNEVKAIK NTFGEAAKHL KVSSTKSMTG HLLGATGGIE
360 370 380 390 400
AIFSALSIKD SKVAPTIHAV TPDPECDLDI VPNEAQDLDI TYAMSNSLGF
410
GGHNAVLVFK KFEA
Length:414
Mass (Da):43,739
Last modified:October 1, 2002 - v1
Checksum:i2DB06BB5DD48D175
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000033 Genomic DNA. Translation: BAB94731.1.
RefSeqiNP_645683.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB94731; BAB94731; BAB94731.
GeneIDi1002978.
KEGGisam:MW0866.
PATRICi19568299. VBIStaAur44266_0911.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000033 Genomic DNA. Translation: BAB94731.1 .
RefSeqi NP_645683.1. NC_003923.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2GQD X-ray 2.30 A/B 1-414 [» ]
ProteinModelPortali Q8NXE1.
SMRi Q8NXE1. Positions 4-414.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196620.MW0866.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB94731 ; BAB94731 ; BAB94731 .
GeneIDi 1002978.
KEGGi sam:MW0866.
PATRICi 19568299. VBIStaAur44266_0911.

Phylogenomic databases

eggNOGi COG0304.
HOGENOMi HOG000060166.
KOi K09458.
OMAi HAQKRNA.
OrthoDBi EOG6DG2SR.

Enzyme and pathway databases

UniPathwayi UPA00094 .
BioCyci SAUR196620:GJ9Z-888-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q8NXE1.

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR017568. 3-oxoacyl-ACP_synth-2.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000447. KAS_II. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
TIGRFAMsi TIGR03150. fabF. 1 hit.
PROSITEi PS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MW2.

Entry informationi

Entry nameiFABF_STAAW
AccessioniPrimary (citable) accession number: Q8NXE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 1, 2002
Last modified: October 1, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3