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Q8NWU6

- TYRA_STAAW

UniProt

Q8NWU6 - TYRA_STAAW

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Protein

Prephenate dehydrogenase

Gene
tyrA, MW1252
Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Catalytic activityi

Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi3 – 3331NAD Reviewed predictionAdd
BLAST

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. prephenate dehydrogenase (NADP+) activity Source: InterPro
  3. prephenate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. tyrosine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-1276-MONOMER.
UniPathwayiUPA00122; UER00961.

Names & Taxonomyi

Protein namesi
Recommended name:
Prephenate dehydrogenase (EC:1.3.1.12)
Short name:
PDH
Gene namesi
Name:tyrA
Ordered Locus Names:MW1252
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000418: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363Prephenate dehydrogenasePRO_0000282659Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196620.MW1252.

Structurei

3D structure databases

ProteinModelPortaliQ8NWU6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 291290Prephenate/arogenate dehydrogenaseAdd
BLAST
Domaini296 – 36368ACTAdd
BLAST

Sequence similaritiesi

Contains 1 ACT domain.

Phylogenomic databases

eggNOGiCOG0287.
HOGENOMiHOG000043494.
KOiK04517.
OMAiHAMAGTH.
OrthoDBiEOG6B8XMB.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR002912. ACT_dom.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PfamiPF02153. PDH. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NWU6-1 [UniParc]FASTAAdd to Basket

« Hide

MTTVLFVGLG LIGGSLASNI KYHNPNTNII AYDADTSQLD KAKSIGIINE    50
KCLNYSEAIK KADVIIYATP VAITNKYLSE LIDMPTKPGV IVSDTGSTKA 100
MIQQHECNLL KHNIHLVSGH PMAGSHKSGV LNAKKHLFEN AYYILVYNEP 150
RNEQAANTLK ELLSPTLAKF IVTTAEEHDY VTSVVSHLPH IVASSLVHVS 200
QKNGQEHHLV NKLAAGGFRD ITRIASSNAQ MWKDITLSNK TYILEMIRQL 250
KSQFQDLERL IESNDSEKLL SFFAQAKSYR DALPAKQLGG LNTAYDLYVD 300
IPDESGMISK VTYILSLHNI SISNLRILEV REDIYGALKI SFKNPTDRER 350
GMQALSDFDC YIQ 363
Length:363
Mass (Da):40,395
Last modified:October 1, 2002 - v1
Checksum:i8F16333DC3B816C6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000033 Genomic DNA. Translation: BAB95117.1.
RefSeqiNP_646069.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB95117; BAB95117; BAB95117.
GeneIDi1003364.
KEGGisam:MW1252.
PATRICi19569104. VBIStaAur44266_1313.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000033 Genomic DNA. Translation: BAB95117.1 .
RefSeqi NP_646069.1. NC_003923.1.

3D structure databases

ProteinModelPortali Q8NWU6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196620.MW1252.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB95117 ; BAB95117 ; BAB95117 .
GeneIDi 1003364.
KEGGi sam:MW1252.
PATRICi 19569104. VBIStaAur44266_1313.

Phylogenomic databases

eggNOGi COG0287.
HOGENOMi HOG000043494.
KOi K04517.
OMAi HAMAGTH.
OrthoDBi EOG6B8XMB.

Enzyme and pathway databases

UniPathwayi UPA00122 ; UER00961 .
BioCyci SAUR196620:GJ9Z-1276-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR002912. ACT_dom.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view ]
Pfami PF02153. PDH. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
PROSITEi PS51671. ACT. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MW2.

Entry informationi

Entry nameiTYRA_STAAW
AccessioniPrimary (citable) accession number: Q8NWU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 1, 2002
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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