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Protein

Probable CtpA-like serine protease

Gene

MW1310

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei329 – 3291Charge relay systemBy similarity
Active sitei340 – 3401Charge relay systemBy similarity
Active sitei354 – 3541Charge relay systemBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-1334-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable CtpA-like serine protease (EC:3.4.21.-)
Gene namesi
Ordered Locus Names:MW1310
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000418 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei39 – 5921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Probable CtpA-like serine proteasePRO_0000233194Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ8NWR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini124 – 20683PDZPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S41A family.Curated
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000038765.
OMAiNIMQVEY.
OrthoDBiEOG6PS5W5.

Family and domain databases

Gene3Di1.10.101.10. 1 hit.
2.30.42.10. 1 hit.
3.90.226.10. 2 hits.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR001478. PDZ.
IPR004447. Peptidase_S41A.
IPR002477. Peptidoglycan-bd-like.
IPR005151. Tail-specific_protease.
[Graphical view]
PfamiPF13180. PDZ_2. 1 hit.
PF03572. Peptidase_S41. 1 hit.
PF01471. PG_binding_1. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00245. TSPc. 1 hit.
[Graphical view]
SUPFAMiSSF47090. SSF47090. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52096. SSF52096. 2 hits.
TIGRFAMsiTIGR00225. prc. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NWR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDKQHTSSS DDERAEIATS NQDQETNSSK RVHLKRWQFI SILIGTILIT
60 70 80 90 100
AVITVVAYIF INQKISGLNK TDQANLNKIE NVYKILNSDY YKKQDSDKLS
110 120 130 140 150
KAAIDGMVKE LKDPYSEYLT KEQTKSFNEG VSGDFVGIGA EMQKKNDQIM
160 170 180 190 200
VTSPMKGSPA ERAGIRPKDV ITKVNGKSIK GKALDEVVKD VRGKENTEVT
210 220 230 240 250
LTVQRGSEEK DVKIKREKIH VKSVEYKKKG KVGVITINKF QNDTSGELKD
260 270 280 290 300
AVLKAHKDGL KKIVLDLRNN PGGLLDEAVK MANIFIDKGK TVVKLEKGKD
310 320 330 340 350
TEAIQTSNDA LKEAKDMDIS ILVNEGSASA SEVFTGALKD YNKAKVYGSK
360 370 380 390 400
TFGKGVVQTT REFKDGSLLK YTEMKWLTPD GHYIHGKGIK PDVTIDTPKY
410 420 430 440 450
QSLNVIPNTK TFKVGDDDKN IKTIKIGLSA LGYKVDNETT QFDQALENQV
460 470 480 490
KAFQQANKLE VTGEFNKETN NKFTELLVEK ANKHDDVLDK LINILK
Length:496
Mass (Da):55,275
Last modified:October 1, 2002 - v1
Checksum:i9A41BE6069218604
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB95175.1.
RefSeqiWP_000342126.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB95175; BAB95175; BAB95175.
PATRICi19569220. VBIStaAur44266_1371.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB95175.1.
RefSeqiWP_000342126.1. NC_003923.1.

3D structure databases

ProteinModelPortaliQ8NWR2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB95175; BAB95175; BAB95175.
PATRICi19569220. VBIStaAur44266_1371.

Phylogenomic databases

HOGENOMiHOG000038765.
OMAiNIMQVEY.
OrthoDBiEOG6PS5W5.

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-1334-MONOMER.

Family and domain databases

Gene3Di1.10.101.10. 1 hit.
2.30.42.10. 1 hit.
3.90.226.10. 2 hits.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR001478. PDZ.
IPR004447. Peptidase_S41A.
IPR002477. Peptidoglycan-bd-like.
IPR005151. Tail-specific_protease.
[Graphical view]
PfamiPF13180. PDZ_2. 1 hit.
PF03572. Peptidase_S41. 1 hit.
PF01471. PG_binding_1. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00245. TSPc. 1 hit.
[Graphical view]
SUPFAMiSSF47090. SSF47090. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52096. SSF52096. 2 hits.
TIGRFAMsiTIGR00225. prc. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MW2.

Entry informationi

Entry nameiCTPAL_STAAW
AccessioniPrimary (citable) accession number: Q8NWR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 1, 2002
Last modified: March 16, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.