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Protein

Quinolone resistance protein NorB

Gene

norB

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Multidrug efflux pump that acts independently of NorA and is one of the factors that confers resistance against diverse quinolones and chemical compounds (By similarity). Can facilitate bacterial survival in vivo when overexpressed in an abscess and may contribute to the relative resistance of staphylococcal abscesses to antimicrobial therapy.By similarity1 Publication

GO - Biological processi

Keywordsi

Biological processAntibiotic resistance, Transport, Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Quinolone resistance protein NorB
Gene namesi
Name:norB
Ordered Locus Names:MW1325
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000418 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Transmembranei273 – 293HelicalSequence analysisAdd BLAST21
Transmembranei299 – 319HelicalSequence analysisAdd BLAST21
Transmembranei334 – 354HelicalSequence analysisAdd BLAST21
Transmembranei357 – 377HelicalSequence analysisAdd BLAST21
Transmembranei403 – 423HelicalSequence analysisAdd BLAST21
Transmembranei435 – 455HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003619621 – 463Quinolone resistance protein NorBAdd BLAST463

Expressioni

Inductioni

Transcription is highly induced in abscesses. Up-regulated by MgrA. Down-regulated during stationary-phase.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ8NWQ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000263641
KOiK08170
OMAiGFGMSPK

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 2 hits
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NWQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKPSREAFE GNNKLLIGIV LSVITFWLFA QSLVNVVPIL EDSFNTDIGT
60 70 80 90 100
VNIAVSITAL FSGMFVVGAG GLADKYGRIK LTNIGIILNI LGSLLIIISN
110 120 130 140 150
IPLLLIIGRL IQGLSAACIM PATLSIIKSY YIGKDRQRAL SYWSIGSWGG
160 170 180 190 200
SGVCSFFGGA VATLLGWRWI FILSIIISLI ALFLIKGTPE TKSKSISLNK
210 220 230 240 250
FDIKGLVLLV IMLLSLNILI TKGSELGVSS LLFITLLAIA IGSFSLFIVL
260 270 280 290 300
EKRATNPLID FKLFKNKAYT GATASNFLLN GVAGTLIVAN TFVQRGLGYS
310 320 330 340 350
SLQAGSLSIT YLVMVLIMIR VGEKLLQTLG CKKPMLIGTG VLIVGECLIS
360 370 380 390 400
LTFLPEILYV ICCIIGYLFF GLGLGIYATP STDTAIANAP LEKVGVAAGI
410 420 430 440 450
YKMASALGGA FGVALSGAVY AIVSNMTNIY TGAMIALWLN AGMGILSFVI
460
ILLLVPKQND TQL
Length:463
Mass (Da):49,245
Last modified:October 1, 2002 - v1
Checksum:i2FE8511AC4A5F4F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA Translation: BAB95190.1
RefSeqiWP_000414682.1, NC_003923.1

Genome annotation databases

EnsemblBacteriaiBAB95190; BAB95190; BAB95190
KEGGisam:MW1325

Similar proteinsi

Entry informationi

Entry nameiNORB_STAAW
AccessioniPrimary (citable) accession number: Q8NWQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health