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Protein

Quinolone resistance protein NorB

Gene

norB

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Multidrug efflux pump that acts independently of NorA and is one of the factors that confers resistance against diverse quinolones and chemical compounds (By similarity). Can facilitate bacterial survival in vivo when overexpressed in an abscess and may contribute to the relative resistance of staphylococcal abscesses to antimicrobial therapy.By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance, Transport, Virulence

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-1349-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Quinolone resistance protein NorB
Gene namesi
Name:norB
Ordered Locus Names:MW1325
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000418 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721HelicalSequence analysisAdd
BLAST
Transmembranei53 – 7321HelicalSequence analysisAdd
BLAST
Transmembranei86 – 10621HelicalSequence analysisAdd
BLAST
Transmembranei107 – 12721HelicalSequence analysisAdd
BLAST
Transmembranei142 – 16221HelicalSequence analysisAdd
BLAST
Transmembranei165 – 18521HelicalSequence analysisAdd
BLAST
Transmembranei201 – 22121HelicalSequence analysisAdd
BLAST
Transmembranei230 – 25021HelicalSequence analysisAdd
BLAST
Transmembranei273 – 29321HelicalSequence analysisAdd
BLAST
Transmembranei299 – 31921HelicalSequence analysisAdd
BLAST
Transmembranei334 – 35421HelicalSequence analysisAdd
BLAST
Transmembranei357 – 37721HelicalSequence analysisAdd
BLAST
Transmembranei403 – 42321HelicalSequence analysisAdd
BLAST
Transmembranei435 – 45521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 463463Quinolone resistance protein NorBPRO_0000361962Add
BLAST

Expressioni

Inductioni

Transcription is highly induced in abscesses. Up-regulated by MgrA. Down-regulated during stationary-phase.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ8NWQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000263641.
OMAiLAWQERR.
OrthoDBiEOG6HB9M6.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NWQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKPSREAFE GNNKLLIGIV LSVITFWLFA QSLVNVVPIL EDSFNTDIGT
60 70 80 90 100
VNIAVSITAL FSGMFVVGAG GLADKYGRIK LTNIGIILNI LGSLLIIISN
110 120 130 140 150
IPLLLIIGRL IQGLSAACIM PATLSIIKSY YIGKDRQRAL SYWSIGSWGG
160 170 180 190 200
SGVCSFFGGA VATLLGWRWI FILSIIISLI ALFLIKGTPE TKSKSISLNK
210 220 230 240 250
FDIKGLVLLV IMLLSLNILI TKGSELGVSS LLFITLLAIA IGSFSLFIVL
260 270 280 290 300
EKRATNPLID FKLFKNKAYT GATASNFLLN GVAGTLIVAN TFVQRGLGYS
310 320 330 340 350
SLQAGSLSIT YLVMVLIMIR VGEKLLQTLG CKKPMLIGTG VLIVGECLIS
360 370 380 390 400
LTFLPEILYV ICCIIGYLFF GLGLGIYATP STDTAIANAP LEKVGVAAGI
410 420 430 440 450
YKMASALGGA FGVALSGAVY AIVSNMTNIY TGAMIALWLN AGMGILSFVI
460
ILLLVPKQND TQL
Length:463
Mass (Da):49,245
Last modified:October 1, 2002 - v1
Checksum:i2FE8511AC4A5F4F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB95190.1.
RefSeqiWP_000414682.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB95190; BAB95190; BAB95190.
PATRICi19569254. VBIStaAur44266_1388.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB95190.1.
RefSeqiWP_000414682.1. NC_003923.1.

3D structure databases

ProteinModelPortaliQ8NWQ5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB95190; BAB95190; BAB95190.
PATRICi19569254. VBIStaAur44266_1388.

Phylogenomic databases

HOGENOMiHOG000263641.
OMAiLAWQERR.
OrthoDBiEOG6HB9M6.

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-1349-MONOMER.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MW2.
  2. "NorB, an efflux pump in Staphylococcus aureus strain MW2, contributes to bacterial fitness in abscesses."
    Ding Y., Onodera Y., Lee J.C., Hooper D.C.
    J. Bacteriol. 190:7123-7129(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN BACTERIAL SURVIVAL WITHIN AN ABSCESS, INDUCTION.

Entry informationi

Entry nameiNORB_STAAW
AccessioniPrimary (citable) accession number: Q8NWQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: October 1, 2002
Last modified: March 16, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.