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Protein

Sensor protein SrrB

Gene

srrB

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Member of the two-component regulatory system SrrA/SrrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. Probably phosphorylates SrrA (By similarity).By similarity

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Two-component regulatory system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sensor protein SrrB (EC:2.7.13.3)
Alternative name(s):
Staphylococcal respiratory response protein B
Gene namesi
Name:srrB
Ordered Locus Names:MW1445
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000418 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 174ExtracellularSequence analysisAdd BLAST142
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 583CytoplasmicSequence analysisAdd BLAST388

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000748871 – 583Sensor protein SrrBAdd BLAST583

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei369Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ8NWF3.
SMRiQ8NWF3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini197 – 249HAMPPROSITE-ProRule annotationAdd BLAST53
Domaini366 – 583Histidine kinasePROSITE-ProRule annotationAdd BLAST218

Sequence similaritiesi

Contains 1 HAMP domain.PROSITE-ProRule annotation
Contains 1 histidine kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000223176.
KOiK07651.

Family and domain databases

CDDicd06225. HAMP. 1 hit.
Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NWF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSRLNSVVI KLWLTIILIV TTVLILLSIA LITFMQYYFT QETENAIRED
60 70 80 90 100
ARRISSLVEQ SHNKEEAIKY SQTLIENPGG LMIINNKHRQ STASLSNIKK
110 120 130 140 150
QMLNEVVNND HFDDVFDKGK SVTRNVTIKE KGSSQTYILL GYPTKAQKNS
160 170 180 190 200
HSKYSGVFIY KDLKSIEDTN NAITIITIIT AVIFLTITTV FAFFLSSRIT
210 220 230 240 250
KPLRRLRDQA TRVSEGDYSY KPSVTTKDEI GQLSQAFNQM STEIEEHVDA
260 270 280 290 300
LSTSKNIRDS LINSMVEGVL GINESRQIIL SNKMANDIMD NIDEDAKAFL
310 320 330 340 350
LRQIEDTFKS KQTEMRDLEM NARFFVVTTS YIDKIEQGGK SGVVVTVRDM
360 370 380 390 400
TNEHNLDQMK KDFIANVSHE LRTPISLLQG YTESIVDGIV TEPDEIKESL
410 420 430 440 450
AIVLDESKRL NRLVNELLNV ARMDAEGLSV NKEVQPIAAL LDKMKIKYRQ
460 470 480 490 500
QADDLGLNMT FNYCKKRVWS YDMDRMDQVL TNLIDNASRY TKPGDEIAIT
510 520 530 540 550
CDENESEDIL YIKDTGTGIA PEHLQQVFDR FYKVDAARTR GKQGTGLGLF
560 570 580
ICKMIIEEHG GSIDVKSELG KGTTFIIKLP KPE
Length:583
Mass (Da):66,076
Last modified:September 27, 2005 - v2
Checksum:i7305F6883B016640
GO

Sequence cautioni

The sequence BAB95310 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB95310.1. Different initiation.
RefSeqiWP_000987769.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB95310; BAB95310; BAB95310.
GeneIDi28380922.
KEGGisam:MW1445.
PATRICi19569498. VBIStaAur44266_1510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB95310.1. Different initiation.
RefSeqiWP_000987769.1. NC_003923.1.

3D structure databases

ProteinModelPortaliQ8NWF3.
SMRiQ8NWF3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB95310; BAB95310; BAB95310.
GeneIDi28380922.
KEGGisam:MW1445.
PATRICi19569498. VBIStaAur44266_1510.

Phylogenomic databases

HOGENOMiHOG000223176.
KOiK07651.

Family and domain databases

CDDicd06225. HAMP. 1 hit.
Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSRRB_STAAW
AccessioniPrimary (citable) accession number: Q8NWF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: September 27, 2005
Last modified: November 2, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.